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Measuring the relative information in allele-sharing linkage studies

Publication Year: 2004 Source: Biometrics PMID: 15180662 DOI: 10.1111/j.0006-341X.2004.00181.x

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A prospective randomized observer-blind 2-year trial of azathioprine monotherapy versus azathioprine and olsalazine for the maintenance of remission of steroid-dependent ulcerative colitis

Publication Year: 2004 Source: Am J Gastroenterol PMID: 15180735 DOI: 10.1111/j.1572-0241.2004.11481.x

Comment in J Pediatr Gastroenterol Nutr. 2003 Sep;37(3):228-9. BACKGROUND: Cytokines appear to play a significant role in the pathogenesis of inflammatory bowel disease (IBD) with a predominant Th2 pattern in colonic mucosa of patients with ulcerative colitis (UC). Chemokines and their receptors also regulate the migration of Th1 or Th2 …

Psychological stress and inflammatory bowel disease: a follow-up study in parents who lost a child in Denmark

Publication Year: 2004 Source: Am J Gastroenterol PMID: 15180736 DOI: 10.1111/j.1572-0241.2004.04155.x

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Intestinal epithelial cell regulation of mucosal inflammation

Publication Year: 2004 Source: Immunol Res PMID: 15181270 DOI: 10.1385/IR:29:1-3:055

BACKGROUND: The OPS imaging technique has been introduced for in vivo assessment of microcirculation in humans. The aim of this study was to validate the new technique against intravital fluorescence microscopy (IFM) for the visualization of colon microcirculation in a murine model of inflammatory bowel disease (IBD). METHOD: IBD was …

Inhibition of glycolipid biosynthesis by N-(5-adamantane-1-yl-methoxy-pentyl)-deoxynojirimycin protects against the inflammatory response in hapten-induced colitis

Publication Year: 2004 Source: Int Immunopharmacol PMID: 15182733 DOI: 10.1016/j.intimp.2004.04.008

BACKGROUND: Ulcerative colitis is a well-known risk factor for colorectal cancer. AIM: To take a census of the cases of colorectal cancer in ulcerative colitis patients observed in Italy and to evaluate the clinical presentation of neoplastic complication. PATIENTS AND METHODS: Experts from 28 Italian centres specialised in the management …

Differential expression of three matrix metalloproteinases, MMP-19, MMP-26, and MMP-28, in normal and inflamed intestine and colon cancer

Publication Year: 2004 Source: Dig Dis Sci PMID: 15185874 DOI: 10.1023/b:ddas.0000026314.12474.17

OBJECTIVE AND METHOD: Primary sclerosing cholangitis (PSC) is a disease that predominantly affects the biliary tree, although the pancreas may also be affected. A review of the presenting features of all patients given a diagnosis of PSC at a single center was conducted. The aim was to clarify the presentation …

Nutrition support for pediatric patients with inflammatory bowel disease: a clinical report of the North American Society for Pediatric Gastroenterology, Hepatology And Nutrition

Publication Year: 2004 Source: J Pediatr Gastroenterol Nutr PMID: 15187775 DOI: 10.1097/00005176-200407000-00005

Eosinophilic granulocytes were found to be autofluorescent when Giemsa-stained sections were stimulated with indirect light fluorescence (ILF). The frequency of autofluorescent eosinophils was assessed in areas with diffuse and focal inflammation in 76 consecutive colonoscopic biopsies from patients with inflammatory bowel disease (IBD), Crohn's disease (CD = 32), ulcerative colitis …

5-aminosalicylic acids and the risk of renal disease: a large British epidemiologic study

Publication Year: 2004 Source: Gastroenterology PMID: 15188168 DOI: 10.1053/j.gastro.2004.03.016

BACKGROUND & AIMS: Although bone loss and osteoporosis are well-known long-term sequelae of inflammatory bowel disease (IBD), the risk factors for increased bone loss have not been identified. Balances of pro- and anti-inflammatory cytokines influence mechanisms of both chronic inflammation and bone resorption. The aim of this study was to …

Failure to induce oral tolerance to a soluble protein in patients with inflammatory bowel disease

Publication Year: 2004 Source: Gastroenterology PMID: 15188172 DOI: 10.1053/j.gastro.2004.03.076

Enhanced expression of mucosal addressin cell adhesion molecule-1 (MAdCAM-1) and other endothelial cell adhesion molecules (ECAMs) are associated with the onset and progression of inflammatory bowel disease (IBD). We show in this study that two cytochrome p-450 (CYP450) inhibitors from Citrus paradis (grapefruit), bergamottin, and 6',7'-dihydroxybergamottin (DHB) block tumor necrosis …

Isolation by distance and sharp discontinuities in gene frequencies: implications for the phylogeography of an alpine insect species, Carabus solieri

Publication Year: 2004 Source: Mol Ecol PMID: 15189211 DOI: 10.1111/j.1365-294X.2004.02212.x

BACKGROUND: This paper reports the results of a systematic survey of members of a clinical gastroenterology service to determine their perceptions of patients with inflammatory bowel disease (IBD) who were deemed to function poorly and were difficult to manage clinically. OBJECTIVES: To assess objectively the defining characteristics of this perceived …

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