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Efficacy of a transforming growth factor beta 2 containing nutritional support formula in a murine model of inflammatory bowel disease
Publication Year: 2004 Source: J Am Coll Nutr PMID: 15190046 DOI: 10.1080/07315724.2004.10719364
IL-22, an IL-10 family cytokine, is produced by different leukocyte subsets, including T cells, NK cells and lymphoid tissue inducer (LTi) cells. IL-22 mediates the crosstalk between leukocytes and tissue epithelia because its receptor is preferentially expressed on various tissue epithelial cells. IL-22 is essential for host defense against infections …
Determination of fexofenadine in human plasma using 96-well solid phase extraction and HPLC with tandem mass spectrometric detection
Publication Year: 2004 Source: J Pharm Biomed Anal PMID: 15193728 DOI: 10.1016/j.jpba.2004.02.016
HLA-B27 transgenic rats spontaneously developing a chronic inflammation mainly involving the colon are recognized as a powerful animal model for IBD. We investigated the mucin production in 6-month-old HLA-B27 rats by measuring in vivo fractional synthesis rate (FSR) and expression of mucins. In the inflamed colon of HLA-B27 rats, the …
Epidemiology of appendicectomy in primary sclerosing cholangitis and ulcerative colitis: its influence on the clinical behaviour of these diseases
Publication Year: 2004 Source: Gut PMID: 15194646 DOI: 10.1136/gut.2003.036483
Cytomegalovirus (CMV) colitis is rarely reported in the immuno-competent adult and is often associated with inflammatory bowel disease (IBD), particularly ulcerative colitis (UC). An index of suspicion in the appropriate setting is vital to diagnosing the condition. Undiagnosed CMV colitis has a significant morbidity. A review of the natural history …
Genome wide scan in a Flemish inflammatory bowel disease population: support for the IBD4 locus, population heterogeneity, and epistasis
Publication Year: 2004 Source: Gut PMID: 15194648 DOI: 10.1136/gut.2003.034033
Comment in J Pediatr Gastroenterol Nutr. 2004 Aug;39(2):215-6. OBJECTIVES: Thromboembolism is a significant cause of morbidity and mortality in patients with inflammatory bowel disease (IBD). Plasma total homocysteine (tHcy) is a risk factor for vascular disease and has been implicated as a mediator of thromboembolic events in adults with IBD. …
Deficient host-bacteria interactions in inflammatory bowel disease? The toll-like receptor (TLR)-4 Asp299gly polymorphism is associated with Crohn's disease and ulcerative colitis
Publication Year: 2004 Source: Gut PMID: 15194649 DOI: 10.1136/gut.2003.030205
OBJECTIVES: The aims of this study were: 1) to determine the total costs of care and costs related to lower GI-related problems for patients who received a diagnosis of irritable bowel syndrome (IBS), and 2) to compare them to age- and sex-matched population controls and patients treated for inflammatory bowel …
[Genetic polymorphism and treatment of chronic bowel inflammatory diseases: the example of azathioprine]
Publication Year: 2004 Source: Therapie PMID: 15199672 DOI: 10.2515/therapie:2004015
Dietary antigens may act as important stimuli of the mucosal immune system and have led to the study of nutritional therapy for IBD. Patients with active CD respond to bowel rest, along with total enteral nutrition or TPN. Bowel rest and TPN are as effective as corticosteroids at inducing remission …
Immunoglobulin coating of faecal bacteria in inflammatory bowel disease
Publication Year: 2004 Source: Eur J Gastroenterol Hepatol PMID: 15201580 DOI: 10.1097/01.meg.0000108346.41221.19
BACKGROUND: Inflammatory bowel disease (IBD) has increased exponentially in industrialized nations over the last 50 years. Previous New Zealand studies have shown that IBD is less common than in other countries; however, clinical observations suggested a high incidence and prevalence of IBD in Canterbury, particularly Crohn's disease (CD). AIM: This …
Colonoscopy and SeHCAT for investigation of chronic diarrhea
Publication Year: 2004 Source: Digestion PMID: 15205569 DOI: 10.1159/000079150
Linkage studies that aim to map susceptibility genes for complex diseases commonly test for excess allele sharing among affected relatives. Conventional methods based on identical-by-descent IBD allele sharing do not allow for possible differences among families, such as arise in the case of locus heterogeneity, and thus have reduced ability …
Design of pH-sensitive microspheres for the colonic delivery of the immunosuppressive drug tacrolimus
Publication Year: 2004 Source: Eur J Pharm Biopharm PMID: 15207535 DOI: 10.1016/j.ejpb.2004.01.003
We analyzed 448 independently ascertained reciprocal translocations and 220 inversions referred to our diagnostic laboratory. Twenty-eight percent of the translocations and 8.5% of the inversions arose de novo, the proportion being influenced by the method of ascertainment. It was highest, 47%, among translocations ascertained through an abnormal phenotype. With the …
Linkage disequlibrium in the DTNBP1 (dysbindin) gene region and on chromosome 1p36 among psychotic patients from a genetic isolate in Israel: findings from identity by descent haplotype sharing analysis
Publication Year: 2004 Source: Am J Med Genet B Neuropsychiatr Genet PMID: 15211634 DOI: 10.1002/ajmg.b.30044
Our Markov chain Monte Carlo (MCMC) methods were used in linkage analyses of the Framingham Heart Study data using all available pedigrees. Our goal was to detect and map loci associated with covariate-adjusted traits log triglyceride (lnTG) and high-density lipoprotein cholesterol (HDL) using multipoint LOD score analysis, Bayesian oligogenic linkage …
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