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Inflammatory bowel disease
Publication Year: 2004 Source: Adolesc Med Clin PMID: 15272257 DOI: 10.1016/j.admecli.2003.11.012
PURPOSE: Accurately classifying inflammatory bowel disease (IBD) type in pediatric patients may impact medical decision-making, direct therapy, and improve outcomes. METHODS: This was a prospective cohort study evaluating classification of IBD and patient management with use of capsule endoscopy in pediatric patients with suspected or known IBD. Treating physicians completed …
PDE4 inhibition: a novel approach for the treatment of inflammatory bowel disease
Publication Year: 2004 Source: Trends Pharmacol Sci PMID: 15276712 DOI: 10.1016/j.tips.2004.06.008
Comment in Am J Gastroenterol. 2005 Aug;100(8):1897-8. OBJECTIVES: We reviewed data to investigate the effect of 5-ASA drugs, metronidazole, ciprofloxacin, prednisone, 6-mercaptopurine, azathioprine, and cyclosporine on pregnancy outcomes in patients with inflammatory bowel disease (IBD). METHODS: One hundred and thirteen female patients with a total of 207 documented conceptions were …
Dogs as potential carriers of infectious bursal disease virus
Publication Year: 2004 Source: Avian Pathol PMID: 15276989 DOI: 10.1080/0307945042000195821
Nonparametric linkage analysis is widely used to map susceptibility genes for complex diseases. This paper introduces six nonparametric statistics for measuring marker allele sharing among the affected members of a pedigree. We compare the power of these new statistics and three previous statistics to detect linkage with Mendelian diseases having …
Perinatal outcomes in inflammatory bowel disease
Publication Year: 2004 Source: J Matern Fetal Neonatal Med PMID: 15280131 DOI: 10.1080/14767050410001668662
OBJECTIVE: The internet has been touted as a cost-effective method of providing valuable patient education and support resources. However, little is known of the level of internet interest in or access to web-based resources of most chronically ill populations generally, and pediatric populations in particular. Web-based patient resources could be …
Identifying the susceptibility gene(s) in a set of trait-linked genes using genotype data
Publication Year: 2004 Source: Genetics PMID: 15280254 DOI: 10.1534/genetics.103.021600
BACKGROUND: Gastroenterologists are often hampered by the lack of a reliable, non-invasive index of bowel inflammation when establishing a differential diagnosis for patients presenting with chronic diarrhoea. Investigations aim to distinguish between inflammatory bowel disease (IBD) (e.g. Crohn's disease, ulcerative colitis) and irritable bowel syndrome (IBS). As an acute phase …
Pathogenicity and molecular analysis of an infectious bursal disease virus isolated from Malaysian village chickens
Publication Year: 2004 Source: Avian Dis PMID: 15283430 DOI: 10.1637/7089
Infectious bursal disease (IBD) is still a significant threat facing the Egyptian poultry industry. In this study, eight very virulent IBD viruses (vvIBDV), originating from acute IBD outbreaks recorded in lower and upper Egypt, were studied with respect to their ability to replicate in cell culture, antigenicity and immunogenicity of …
Experience with granulocytapheresis in Crohn's disease
Publication Year: 2004 Source: Rev Esp Enferm Dig PMID: 15283632 DOI: 10.4321/s1130-01082004000700007
A growing number of Campylobacter species other than C. jejuni and C. coli have been recognized as emerging human and animal pathogens. Although C. jejuni continues to be the leading cause of bacterial gastroenteritis in humans worldwide, advances in molecular biology and development of innovative culture methodologies have led to …
Inflammatory bowel disease: the role of environmental factors
Publication Year: 2004 Source: Autoimmun Rev PMID: 15288007 DOI: 10.1016/j.autrev.2004.03.002
Renal manifestations and complications are not rare in patients with inflammatory bowel disease (IBD) and may present as nephrolithiasis, amyloidosis, tubulointerstitial nephritis, and glomerulonephritis. Symptoms of renal impairment are not always specific and since the underlying bowel disease is preponderant, renal function deterioration may be underestimated. Additionally, medical treatment of …
Inhibition of p38 MAP kinase- and RICK/NF-kappaB-signaling suppresses inflammatory bowel disease
Publication Year: 2004 Source: FASEB J PMID: 15289440 DOI: 10.1096/fj.04-1642fje
BACKGROUND & AIMS: Reports of tuberculosis (TB) in patients administered infliximab prompted the Food and Drug Administration to recommend that all patients being considered for this therapy be evaluated for the risk for latent TB infection by means of a tuberculin skin test (TST). The aim of this study is …
Inflammatory bowel disease is linked to 19p13 and associated with ICAM-1
Publication Year: 2004 Source: Inflamm Bowel Dis PMID: 15290909 DOI: 10.1097/00054725-200405000-00001
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