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Spatio-temporal dynamics of a neutralized B chromosome in the grasshopper Eyprepocnemis plorans
Publication Year: 2004 Source: Cytogenet Genome Res PMID: 15292619 DOI: 10.1159/000079315
BACKGROUND: Gut protein loss is a characteristic of inflammatory bowel disease (IBD), and immunoglobulin (Ig) G, albumin and alpha1-antitrypsin concentrations in whole gut lavage fluid (WGLF) correlate with clinical disease activity. If inflammation in ileoanal pouches is similar to IBD, then measurement of protein-losing enteropathy by analysis of WGLF may …
Safety aspects of infliximab in inflammatory bowel disease patients. A retrospective cohort study in 100 patients of a German University Hospital
Publication Year: 2004 Source: Digestion PMID: 15297773 DOI: 10.1159/000080075
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High prevalence of adherent-invasive Escherichia coli associated with ileal mucosa in Crohn's disease
Publication Year: 2004 Source: Gastroenterology PMID: 15300573 DOI: 10.1053/j.gastro.2004.04.061
Mycophenolate mofetil (MMF) is widely used for maintenance immunosuppression in solid organ transplantation. Gastrointestinal toxicity, usually manifested as diarrhea, is the most common side effect of MMF. We evaluated colonic biopsies from 20 renal transplant patients with MMF-related diarrhea. The latter was defined by the absence of any other demonstrable …
Making microbes work for mankind--clever trick or a glimpse of the future for IBD treatment?
Publication Year: 2004 Source: Gastroenterology PMID: 15300597 DOI: 10.1053/j.gastro.2004.06.029
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Score test for detecting linkage to complex traits in selected samples
Publication Year: 2004 Source: Genet Epidemiol PMID: 15305326 DOI: 10.1002/gepi.20012
Leprosy is a chronic disease caused by infection with Mycobacterium leprae, which is manifested across a wide clinical spectrum. There is evidence that susceptibility both to leprosy per se and to the clinical type of leprosy is influenced by host genetic factors. This paper describes the application of an identity …
Guidelines for the management of inflammatory bowel disease in adults
Publication Year: 2004 Source: Gut PMID: 15306569 DOI: 10.1136/gut.2004.043372
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CCR2 expressing CD4+ T lymphocytes are preferentially recruited to the ileum in Crohn's disease
Publication Year: 2004 Source: Gut PMID: 15306587 DOI: 10.1136/gut.2003.028225
BACKGROUND & AIMS: Previous studies have suggested that intestinal epithelial cells (IECs) may function as antigen-presenting cells for CD4+ and CD8+ T cells. However, these cells fail to express conventional costimulatory molecules (CD80, CD86), leading to the possibility that antigen presented by normal IECs could result in anergy. Other members …
Divergent patterns of total and cancer mortality in ulcerative colitis and Crohn's disease patients: the Florence IBD study 1978-2001
Publication Year: 2004 Source: Gut PMID: 15306591 DOI: 10.1136/gut.2003.031476
BACKGROUND: Chemokines regulate the pathways that restrict homing of specific subsets of immune cells, and thereby fine tune the immune response at specific lymphoid and peripheral tissues. CCL2 is a chemokine that induces migration of monocytes, memory T cells, and dendritic cells. Previously, we demonstrated that pM levels of CCL2 …
Commentary: the role of the IL-18 system and other members of the IL-1R/TLR superfamily in innate mucosal immunity and the pathogenesis of inflammatory bowel disease: friend or foe?
Publication Year: 2004 Source: Eur J Immunol PMID: 15307167 DOI: 10.1002/eji.200425351
Comment in Gut. 2004 Jul;53(7):1056. BACKGROUND: Inflammatory bowel disease (IBD) is known to be associated with reduced bone density but the extent to which this results in an increased risk of fracture and the contribution of corticosteroid therapy are unclear. We have conducted a large cohort study to address these …
Erythema nodosum: an experience of 10 years
Publication Year: 2004 Source: Scand J Infect Dis PMID: 15307561 DOI: 10.1080/00365540410027184
Inflammatory bowel diseases (IBDs), including Crohn's disease and ulcerative colitis are chronic inflammatory disorders of gastrointestinal tract. Although the etiology is incompletely understood, initiation and aggravation of the inflammatory process seem to be due to a massive local mucosal immune response. Interleukin-10 (IL-10) is a regulatory cytokine which inhibits both …
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