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Interactions of commensal gut microbes with subsets of B- and T-cells in the murine host
Publication Year: 2004 Source: Vaccine PMID: 15040931 DOI: 10.1016/j.vaccine.2003.11.022
BACKGROUND AND AIMS: The inflammatory bowel disease questionnaire (IBDQ) is the standard instrument for assessment of health-related quality of life (HRQOL) in patients with inflammatory bowel diseases. It has not been validated for patients with ileal pouch anal anastomosis (IPAA) and ulcerative colitis (UC). METHODS: To determine acceptance (percentage of …
Stimulation of peripheral blood and intestinal mucosa cells by synthetic CpG oligodeoxynucleotides
Publication Year: 2004 Source: Hum Immunol PMID: 15041160 DOI: 10.1016/j.humimm.2003.12.013
BACKGROUND: Although an accurate diagnosis of inflammatory bowel disease (IBD) and differentiation between ulcerative colitis (UC) and Crohn's disease (CD) can be made in most patients, it is sometimes impossible to distinguish UC from CD even after thorough pathological study. Recently, clinicians have used the term indeterminate colitis (IC) for …
A protective effect of the synthetic coumarine derivative Cloricromene against DNB-colitis in the rat
Publication Year: 2004 Source: Life Sci PMID: 15043989 DOI: 10.1016/j.lfs.2003.10.016
BACKGROUND AND AIMS: Recently, magnetic resonance imaging (MRI) has been introduced in the diagnosis of patients with inflammatory bowel disease (IBD). However, it is still rarely reported in paediatric IBD. We studied the diagnostic value of gadolinium enhanced MRI in revealing inflammation of the distal ileum in children with Crohn's …
Transmission of CARD15 (NOD2) variants within families of patients with inflammatory bowel disease
Publication Year: 2004 Source: Am J Gastroenterol PMID: 15046221 DOI: 10.1111/j.1572-0241.2004.04040.x
INTRODUCTION: Osteoporosis is a frequent and clinically important complication in inflammatory bowel disease (IBD). Prevalence and risk factors have been examined in small numbers of patients. With a nationwide survey of members of the German Crohn's and Ulcerative Colitis Association (DCCV) we wanted to evaluate the situation in a larger …
Is genetic testing in IBD ready for prime time?
Publication Year: 2004 Source: Am J Gastroenterol PMID: 15046223 DOI: 10.1111/j.1572-0241.2004.04074.x
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Alternative medicine use by Canadian ambulatory gastroenterology patients: secular trend or epidemic?
Publication Year: 2004 Source: Am J Gastroenterol PMID: 15046224 DOI: 10.1111/j.1572-0241.2004.04046.x
In addition to being involved in nutrient uptake, the epithelial mucosa constitute the first line of defense against microbial pathogens. A direct consequence of this physiological function is a very complex network of immunological interactions that lead to a strong control of the mucosal immune balance. The dysfunction of immunological …
Pancreatic pseudotumor with sclerosing pancreato-cholangitis: is this a systemic disease?
Publication Year: 2004 Source: Am J Gastroenterol PMID: 15046232 DOI: 10.1111/j.1572-0241.2004.04075.x
Fusidic acid and sodium fusidate (fusidin) are antibiotics with low toxicity and powerful immunomodulatory activities in vitro and in vivo. In this study we have evaluated the effect of fusidin on the development of dinitrobenzenesulfonic acid (DNB)-induced colitis in rats that serves as a preclinical model of human inflammatory bowel …
Serum procalcitonin and C-reactive protein in children with diarrhoea of various aetiologies
Publication Year: 2004 Source: Acta Paediatr PMID: 15046268 DOI: 10.1080/08035250310021127
Citrobacter rodentium is a classically noninvasive pathogen of mice that is similar to enteropathogenic Escherichia coli (EPEC) in man. Following oral infection of young mice, the organism colonizes the distal colon, and within 1 week the colonic mucosa doubles in thickness and there is massive epithelial cell hyperplasia. Since T-cell …
Clustering patients according to health perceptions: relationships to psychosocial characteristics and medication nonadherence
Publication Year: 2004 Source: J Psychosom Res PMID: 15046970 DOI: 10.1016/S0022-3999(03)00508-7
Numerous therapies used for inflammatory bowel disease (IBD) target the transcription factor NF-kappaB, which is involved in the production of cytokines and chemokines integral for inflammation. Here we show that curcumin, a component of the spice turmeric, is able to attenuate colitis in the dinitrobenzene sulfonic acid (DNB)-induced murine model …
CYFIP2 is highly abundant in CD4+ cells from multiple sclerosis patients and is involved in T cell adhesion
Publication Year: 2004 Source: Eur J Immunol PMID: 15048733 DOI: 10.1002/eji.200324726
This paper proposes variance component models for high resolution joint linkage disequilibrium (LD) and linkage mapping of quantitative trait loci (QTL) based on sibship data; this can include population data if independent individuals are treated as single sibships. One application of these models is late onset complex disease gene mapping, …
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