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Effect of polyherbal formulation on experimental models of inflammatory bowel diseases

Publication Year: 2004 Source: J Ethnopharmacol PMID: 15013181 DOI: 10.1016/j.jep.2003.09.042

BACKGROUND: In inflammatory bowel disease (IBD), gut microvascular thrombosis as well as thromboembolic complications have repeatedly been observed. We examined the long-term course of markers of coagulation and fibrinolysis in relation to clinical disease activity. MATERIALS AND METHODS: In a prospective study, prothrombin fragment 1 and 2 (F1.2), thrombin-antithrombin complex …

Linkage analysis of susceptibility to leprosy type using an IBD regression method

Publication Year: 2004 Source: Genes Immun PMID: 15014432 DOI: 10.1038/sj.gene.6364062

BACKGROUND: It is now well established that susceptibility to inflammatory bowel disease is in part genetic, with one localization on chromosome 6 (IBD3) having been replicated in a number of populations. A candidate in that region, TNF-α, contains polymorphisms in the promoter region that appear to be associated with disease. …

Is inflammatory bowel disease an independent and disease specific risk factor for thromboembolism?

Publication Year: 2004 Source: Gut PMID: 15016749 DOI: 10.1136/gut.2003.025411

We have investigated whether there is a locus on chromosome 6 that confers an increased susceptibility to schizophrenia using a two-stage approach and nonparametric linkage analysis. Allele sharing identical by descent (IBD) and multipoint maximum likelihood score (MLS) statistics were employed. Results from two tested data sets, a first data …

Glucagonlike peptide-2 analogue: a possible new approach in the management of inflammatory bowel disease

Publication Year: 2004 Source: J Pediatr Surg PMID: 15017568 DOI: 10.1016/j.jpedsurg.2003.11.024

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Initial experience with wireless capsule enteroscopy in the diagnosis and management of inflammatory bowel disease

Publication Year: 2004 Source: Clin Gastroenterol Hepatol PMID: 15017630 DOI: 10.1016/s1542-3565(03)00289-1

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Expression of CD45RB functionally distinguishes intestinal T lymphocytes in inflammatory bowel disease

Publication Year: 2004 Source: J Leukoc Biol PMID: 15020649 DOI: 10.1189/jlb.0803400

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Multipoint linkage analysis of quantitative traits on sex-chromosomes

Publication Year: 2004 Source: Genet Epidemiol PMID: 15022208 DOI: 10.1002/gepi.10310

6-mercaptopurine (6-MP) and azathioprine are important drugs for the treatment of inflammatory bowel disease (IBD) but their actions suppress host defense against infection. A challenging case of a 19-year-old female patient with quiescent Crohn's disease maintained with 6-MP presenting with dyspnea and a normal chest exam and x-ray is presented. …

Cathepsin D is up-regulated in inflammatory bowel disease macrophages

Publication Year: 2004 Source: Clin Exp Immunol PMID: 15030527 DOI: 10.1111/j.1365-2249.2004.02420.x

OBJECTIVES: Pyoderma gangrenosum is an immune-mediated inflammatory condition characterized by ulcerative skin lesions affecting 1-2% of patients with inflammatory bowel disease (IBD). Treatment includes wound care, antibiotics, corticosteroids, and immunomodulators. However, response to therapy varies, and many patients with pyoderma gangrenosum have disease that is refractory to these agents. The …

Expression of HLA-G in inflammatory bowel disease provides a potential way to distinguish between ulcerative colitis and Crohn's disease

Publication Year: 2004 Source: Int Immunol PMID: 15039388 DOI: 10.1093/intimm/dxh061

OBJECTIVE: To investigate the expression of Fhit protein in 53 patients with ulcerative colitis and Crohn's disease, as well as in 13 ulcerative-colitis-associated adenocarcinomas, and its eventual relationship with clinicopathological data and response to therapy. MATERIALS AND METHODS: We performed immunohistochemistry in archival material of formalin-fixed, paraffin-embedded tissues using the …

A study of reciprocal translocations and inversions detected by light microscopy with special reference to origin, segregation, and recurrent abnormalities

Publication Year: 2004 Source: Am J Med Genet A PMID: 15039973 DOI: 10.1002/ajmg.a.20553

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