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Mortality in inflammatory bowel disease: a population-based cohort study
Publication Year: 2003 Source: Gastroenterology PMID: 14724808 DOI: 10.1053/j.gastro.2003.09.029
The inflammatory bowel diseases (IBD), Crohn's disease (CD), and ulcerative colitis (UC), are complex multifactorial traits involving both environmental and genetic factors. Mannan-binding lectin (MBL) plays an important role in non-specific immunity and complement activation. Point mutations in codons 52, 54 and 57 of exon 1 of the MBL gene …
Inflammatory bowel disease and the risk of fracture
Publication Year: 2003 Source: Gastroenterology PMID: 14724810 DOI: 10.1053/j.gastro.2003.09.027
Comment in Gut. 2003 Aug;52(8):1227-8; author reply 1228. BACKGROUND AND AIMS: The genetic contribution to inflammatory bowel disease (IBD) is under investigation. Recent evidence indicates a significant linkage between a locus on chromosome 19p13 and IBD. We investigated the association between an intercellular adhesion molecule 1 gene (ICAM-1) polymorphism located …
Colonic bacterial superantigens evoke an inflammatory response and exaggerate disease in mice recovering from colitis
Publication Year: 2003 Source: Gastroenterology PMID: 14724831 DOI: 10.1053/j.gastro.2003.09.020
Enteropathogenic Escherichia coli (EPEC) attaches intimately to mammalian cells via a bacterial outer membrane adhesion molecule, intimin, and its receptor in the host cell membrane, Tir. Tir is a bacterial protein translocated into the host cell membrane and tyrosine phosphorylated after insertion. Tir-intimin binding induces organized actin polymerization beneath the …
Haemostasis in inflammatory bowel diseases: clinical relevance
Publication Year: 2003 Source: Scand J Gastroenterol Suppl PMID: 14743884 DOI: 10.1080/00855920310002708
BACKGROUND: Crohn's disease (CD) and ulcerative colitis (UC) are chronic immunoinflammatory diseases that place a considerable burden on patients, their families, and society. Quality of care plays an important role for patients. A questionnaire to measure quality of care through the eyes of patients with inflammatory bowel disease (QUOTE-IBD) has …
IBD and genetics: new developments
Publication Year: 2003 Source: Scand J Gastroenterol Suppl PMID: 14743885 DOI: 10.1080/00855920310002717
Children and adolescents with inflammatory bowel disease (IBD) tend to have more extensive and severe disease than adults. IBD presenting in childhood interferes with growth, education and employment as well as psychosocial and sexual development, frequently delaying adolescent developmental milestones. Transition, in the context of healthcare, is the purposeful, planned …
Crohn's-like ileo-colitis in patients affected by glycogen storage disease Ib: two years' follow-up of patients with a wide spectrum of gastrointestinal signs
Publication Year: 2003 Source: Acta Paediatr PMID: 14971792 DOI: 10.1080/08035250310007033
BACKGROUND: Patients with inflammatory bowel disease (IBD) have identified a need for more information about their disease. PURPOSE: To assess the effect of an educational intervention on health-related quality of life (HRQOL) in patients with IBD. METHODS: Consecutive ambulatory IBD patients were randomized to receive four IBD-specific educational booklets or …
Mapping complex traits using Random Forests
Publication Year: 2003 Source: BMC Genet PMID: 14975132 DOI: 10.1186/1471-2156-4-S1-S64
CARD15 on chromosome 16 is the only IBD susceptibility gene identified among several mapped loci. Its recurrent variants R702W, G908R and L1007fs have shown significant association with Crohn's disease (CD), but not with ulcerative colitis (UC), in different Caucasian populations. We analysed these three variants in 184 CD and 92 …
Approaches to mapping genetically correlated complex traits
Publication Year: 2003 Source: BMC Genet PMID: 14975139 DOI: 10.1186/1471-2156-4-S1-S71
Regression methods offer a common framework to analyze linkage for quantitative trait loci as well as linkage for affection status using affected sib-pairs. Although numerous papers on regression methods for linkage have been published, some common themes and important caveats tend to be scattered across the literature. For example, the …
On different approximations to multilocus identity-by-descent calculations and the resulting power of variance component-based linkage analysis
Publication Year: 2003 Source: BMC Genet PMID: 14975140 DOI: 10.1186/1471-2156-4-S1-S72
AIM: IBD is a systemic disease associated with a large number of extraintestinal manifestations (EIMs). Our aim was to determine the prevalence of EIMs in a large IBD cohort in Veszprem Province in a 25-year follow-up study. METHODS: Eight hundred and seventy-three IBD patients were enrolled (ulcerative colitis/UC/: 619, m/f: …
Nonparametric longitudinal allele-sharing model
Publication Year: 2003 Source: BMC Genet PMID: 14975153 DOI: 10.1186/1471-2156-4-S1-S85
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