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Shigellosis: innate mechanisms of inflammatory destruction of the intestinal epithelium, adaptive immune response, and vaccine development
Publication Year: 2003 Source: Crit Rev Immunol PMID: 15030306 DOI: 10.1615/critrevimmunol.v23.i56.20
I compare the transmission/disequilibrium test (TDT) and affected sib pair (ASP) test under a general algebraic model describing a bi-allelic disease locus. Assuming linkage to a bi-allelic marker, I derive two binomial probabilities, one for parental allele 'transmission' (Pt) which determines the magnitude of the TDT chi 2 statistic (chi …
High-resolution joint linkage disequilibrium and linkage mapping of quantitative trait loci based on sibship data
Publication Year: 2003 Source: Hum Hered PMID: 15031619 DOI: 10.1159/000076392
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Intestinal lymphocyte populations in children with regressive autism: evidence for extensive mucosal immunopathology
Publication Year: 2003 Source: J Clin Immunol PMID: 15031638 DOI: 10.1023/b:joci.0000010427.05143.bb
Crohn's disease (CD), a chronic relapsing inflammatory condition of the intestines, is a common cause of gastrointestinal morbidity in young people. Although the aetiology of CD is unknown, host, genetic and environmental influences are clearly important. Glucocorticoids remain the mainstay of treatment for active CD, however only two-third of patients …
Inflammatory bowel disease: dysfunction of GALT and gut bacterial flora (II)
Publication Year: 2003 Source: Surgeon PMID: 15570747 DOI: 10.1016/s1479-666x(03)80091-4
An association between celiac disease (CD) and other autoimmune diseases such as connective tissue diseases (CTD), inflammatory bowel diseases (IBD), and primary biliary cirrhosis (PBC) has been reported in several studies. However, a high rate of false positives in autoantibody testing was noted, especially when tissue transglutaminase (tTG) from guinea …
Inflammatory bowel disease: dysfunction of GALT and gut bacterial flora (I)
Publication Year: 2003 Source: Surgeon PMID: 15573623 DOI: 10.1016/s1479-666x(03)80118-x
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TNF-alpha -induced endothelial cell adhesion molecule expression is cytochrome P-450 monooxygenase dependent
Publication Year: 2003 Source: Am J Physiol Cell Physiol PMID: 12388057 DOI: 10.1152/ajpcell.00271.2002
We studied the peripheral T cell compartment of H-2b severe combined immunodeficient (scid) mice that express a transgenic (tg) alpha beta T cell receptor (TcR) specific for the H-Y (male) epitope presented by the H-2 class I Db molecule. Large populations of CD3+ NK1.1-TCR beta T+ T cells were present …
Tumor necrosis factor regulates intestinal epithelial cell migration by receptor-dependent mechanisms
Publication Year: 2003 Source: Am J Physiol Cell Physiol PMID: 12466150 DOI: 10.1152/ajpcell.00309.2002
BACKGROUND & AIMS: Regulatory T cells play a role in the control of immune responses in the intestinal mucosa and their absence may predispose to inflammatory bowel disease (IBD). We have previously shown that T cells activated by intestinal epithelial cells (IECs) are suppressive in function. Our goal was to …
Chemokine expression in IBD. Mucosal chemokine expression is unselectively increased in both ulcerative colitis and Crohn's disease
Publication Year: 2003 Source: J Pathol PMID: 12474223 DOI: 10.1002/path.1245
Nitric oxide (NO) and reactive oxygen species (ROS) are important mediators in the pathogenesis of inflammatory bowel disease (IBD). NO in IBD can be either harmful or protective. NO can react with superoxide anions (O2.-), yielding the toxic oxidizing agent peroxynitrite (ONOO-). Peroxynitrite induces nitration of tyrosine residues (nitrotyrosine), leading …
Increased expression of interleukin 17 in inflammatory bowel disease
Publication Year: 2003 Source: Gut PMID: 12477762 DOI: 10.1136/gut.52.1.65
BACKGROUND: Experimental evidences suggest an increased collagen deposition in inflammatory bowel diseases (IBD). In particular, large amounts of collagen type I, III and V have been described and correlated to the development of intestinal fibrotic lesions. No information has been available until now about the possible increased collagen deposition far …
CARD4/NOD1 is not involved in inflammatory bowel disease
Publication Year: 2003 Source: Gut PMID: 12477763 DOI: 10.1136/gut.52.1.71
OBJECTIVES: To determine the utility of the technetium-labeled autologous white cell scintigraphy (Tc-WCS) for detecting intestinal inflammation in children with suspected inflammatory bowel disease (IBD). Tc-WCS was compared with colonoscopy and histologic examination. STUDY DESIGN: Forty-eight children (26 boys; median age, 10 years; range, 2-17 years) with symptoms and signs …
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