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Platelets trigger a CD40-dependent inflammatory response in the microvasculature of inflammatory bowel disease patients
Publication Year: 2003 Source: Gastroenterology PMID: 12730866 DOI: 10.1016/s0016-5085(03)00289-0
INTRODUCTION: The use of 6-mercaptopurine (6MP) and its prodrug azathioprine (AZA) for inflammatory bowel disease (IBD) has increased in recent years. The pharmacology, patient response in controlled trials, new formulations and routes of administration and safety for these agents are reviewed. PHARMACOLOGY: AZA is rapidly converted to 6MP, which is …
Impaired expression of peroxisome proliferator-activated receptor gamma in ulcerative colitis
Publication Year: 2003 Source: Gastroenterology PMID: 12730867 DOI: 10.1016/s0016-5085(03)00271-3
There is overwhelming evidence in favour of a significant role of reactive oxygen metabolites (ROM) in the pathophysiology of inflammatory bowel disease (IBD) in man and in experimental animal models. This study was undertaken to investigate the possible protective effects of pretreatment with trimetazidine (TMZ) on the oxidant-anti-oxidant balance in …
Is there a role for PPAR gamma in IBD? Yes, no, maybe
Publication Year: 2003 Source: Gastroenterology PMID: 12730893 DOI: 10.1016/s0016-5085(03)00345-7
OBJECTIVE: The present population based adult cohort was part of a new prospective study of patients with inflammatory bowel disease (IBD) in South-Eastern Norway, the Inflammatory Bowel South-Eastern Norway II study, investigating disease characteristics in an attempt to improve our knowledge regarding factors related to early clinical phenotype and disease …
Rabbit chronic ileitis leads to up-regulation of adenosine A1/A3 gene products, oxidative stress, and immune modulation
Publication Year: 2003 Source: Biochem Pharmacol PMID: 12732366 DOI: 10.1016/s0006-2952(03)00067-4
Inflammatory bowel disease (IBD) consisting of ulcerative colitis (UC) and Crohn's (CD) typically displays a waxing and waning course punctuated by disease flares that are characterized by transepithelial migration of neutrophils (PMN) and altered barrier function. Since epithelial barrier function is primarily regulated by the apical most intercellular junction referred …
Gene transfer approaches for the treatment of inflammatory bowel disease
Publication Year: 2003 Source: Gene Ther PMID: 12732871 DOI: 10.1038/sj.gt.3302013
The rocket immunoelectrophoresis (RIE) test was used for the qualitative detection and quantitative estimation of infectious bursal disease virus (IBDV) specific antigen in experimentally infected chickens and samples collected from suspected outbreaks. The IBDV specific antigen was detected in the bursae of experimentally inoculated chickens up to 5 days post …
Interleukin-6 changes tight junction permeability and intracellular phospholipid content in a human enterocyte cell culture model
Publication Year: 2003 Source: Pediatr Surg Int PMID: 12732938 DOI: 10.1007/s00383-003-1003-8
The pathophysiology of inflammatory bowel disease (IBD) involves the production of diverse lipid mediators, namely eicosanoids, lysophospholipids, and platelet-activating factor, in which phospholipase A2 (PLA2) is the key enzyme. Accordingly, it has been postulated that control of lipid mediator production by inhibition of PLA2 would be useful for the treatment …
Perspectives on osteoporosis in pediatric inflammatory bowel disease
Publication Year: 2003 Source: Curr Gastroenterol Rep PMID: 12734045 DOI: 10.1007/s11894-003-0024-8
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Complementary alternative medicine in patients with inflammatory bowel disease: use and attitudes
Publication Year: 2003 Source: Scand J Gastroenterol PMID: 12737442 DOI: 10.1080/00365520310000591a
BACKGROUND: In inflammatory bowel disease (IBD) the disease activity correlates with colonic concentrations of leukotrienes (LTs). The enzyme 5-lipoxygenase (5-LO) is responsible for the enzymatic production of LTs. It has previously been demonstrated in experimental models of inflammation, that 5-LO is activated through intracellular translocation of the pre-formed enzyme, and …
The real cost of pediatric Crohn's disease: the role of infliximab in the treatment of pediatric IBD
Publication Year: 2003 Source: Am J Gastroenterol PMID: 12738445 DOI: 10.1111/j.1572-0241.2003.07396.x
The pathophysiology of inflammatory bowel disease involves excessive immune effects of inflammatory cells against gut microbes. In genetically predisposed individuals, these effects are considered to contribute to the initiation and perpetuation of mucosal injury. Oxidative stress is a fundamental tissue-destructive mechanisms that can occur due to the reactive oxygen species …
IBD: the drugs work...but do the patients?
Publication Year: 2003 Source: Am J Gastroenterol PMID: 12738447 DOI: 10.1111/j.1572-0241.2003.07394.x
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