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[Inflammatory bowel disease: 3 mainly by histology detectable variant forms]
Publication Year: 2003 Source: Ther Umsch PMID: 12693318 DOI: 10.1024/0040-5930.60.3.151
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Altered expression of epimorphin in ulcerative colitis
Publication Year: 2003 Source: J Gastroenterol Hepatol PMID: 12702050 DOI: 10.1046/j.1440-1746.2003.02972.x
OBJECTIVE: The occupational distribution of inflammatory bowel disease (IBD) may help to shed light on its yet unknown etiology. The U.S. vital statistics offer the opportunity to study cause of death by occupation and industry. METHODS: The numbers of deaths from Crohn's disease and ulcerative colitis were retrieved from the …
Colon carcinogenesis in inflammatory bowel disease: applying molecular genetics to clinical practice
Publication Year: 2003 Source: J Clin Gastroenterol PMID: 12702969 DOI: 10.1097/00004836-200305001-00012
Comment on Eur J Gastroenterol Hepatol. 2002 Aug;14(8):841-5. Only a small proportion of patients with abdominal discomfort have organic disease, but a correct diagnosis can seldom be made by simple clinical examination. Additional diagnostic procedures must be employed, but these are expensive and demanding and carry a certain risk. Assessment …
Sonographic prevalence of liver steatosis and biliary tract stones in patients with inflammatory bowel disease: study of 511 subjects at a single center
Publication Year: 2003 Source: J Clin Gastroenterol PMID: 12702985 DOI: 10.1097/00004836-200305000-00012
Inflammation is overall a protective response, whose main goal is to liberate the human being of cellular lesions caused by micro-organisms, toxins, allergens, etc., as well as its consequences, and of death cells and necrotic tissues. Chronic inflammation, which is detrimental to tissues, is the basic pathogenic mechanism of hypersensitivity …
Molecular discoveries alter our view of inflammatory bowel disease. A review from scientific, clinical, and laboratory perspectives
Publication Year: 2003 Source: Am J Clin Pathol PMID: 12710125 DOI: 10.1309/7W3E-TL9N-Q9RH-HX61
OBJECTIVE: To report a case of inflammatory bowel disease (IBD) associated with use of isotretinoin. CASE SUMMARY: 17-year-old boy presented with new-onset rectal bleeding after completion of a five-month course of isotretinoin. A diagnosis of ulcerative colitis was made. His condition worsened despite therapy with 5-aminosalicylic acid, steroid retention enema, …
Very virulent infectious bursal disease virus in southeastern Europe
Publication Year: 2003 Source: Avian Dis PMID: 12713176 DOI: 10.1637/0005-2086(2003)047[0186:VVIBDV]2.0.CO;2
A major problem in inflammatory bowel disease (IBD) is the accumulation of highly activated T-helper cells that are refractory to apoptosis induction. Hence, persistent inflammatory lesions are prevalent and are the basis of chronic disease. In IBD upregulation of costimulatory molecules on lamina propria lymphocytes has been described leading to …
Effect of malnutrition and short-term refeeding on peripheral blood mononuclear cell mitochondrial complex I activity in humans
Publication Year: 2003 Source: Am J Clin Nutr PMID: 12716686 DOI: 10.1093/ajcn/77.5.1304
BACKGROUND AND AIMS: Smoking tobacco has opposite effects on the different forms of inflammatory bowel disease (IBD). It predisposes to the development of Crohn's disease (CD) yet is associated with a reduced incidence of ulcerative colitis (UC). We have studied sib pairs discordant for both smoking and IBD phenotype (UC …
Amelioration of TNBS-induced colon inflammation in rats by phospholipase A2 inhibitor
Publication Year: 2003 Source: Am J Physiol Gastrointest Liver Physiol PMID: 12724134 DOI: 10.1152/ajpgi.00463.2002
Comment in Inflamm Bowel Dis. 2003 Jul;9(4):277. Gastroenterology. 2003 Nov;125(5):1562; author reply 1562. Gastroenterology. 2004 Feb;126(2):628. Gastroenterology. 2004 May;126(5):1493; author reply 1493. BACKGROUND & AIMS: 6-mercaptopurine/azathioprine is effective in IBD patients. However, data regarding toxicity associated with pregnancy are lacking, raising both patients' and physicians' concerns and sometimes resulting in …
Anti-inflammatory properties of the mu opioid receptor support its use in the treatment of colon inflammation
Publication Year: 2003 Source: J Clin Invest PMID: 12727924 DOI: 10.1172/JCI16750
BACKGROUND: MAdCAM-1 is an adhesion molecule expressed in Peyer's patches and lymphoid tissues which is mobilized by cytokines like TNF-alpha and is a major determinant of lymphocyte trafficking to the gut in human inflammatory bowel disease (IBD). It has been suggested that both reactive oxygen and nitrogen metabolites participate in …
Serum IgE and IgG responses to food antigens in normal and atopic dogs, and dogs with gastrointestinal disease
Publication Year: 2003 Source: Vet Immunol Immunopathol PMID: 12730012 DOI: 10.1016/s0165-2427(03)00033-3
INTRODUCTION: Endothelial-bound cell adhesion molecules are important in recruiting inflammatory cells to the mucosa in inflammatory bowel disease (IBD). Little is known of the expression of these molecules in relation to the recruitment of particular cell subtypes in the early course of mucosal inflammation. We therefore studied the expression of …
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