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Colon-specific delivery of prednisolone-appended alpha-cyclodextrin conjugate: alleviation of systemic side effect after oral administration
Publication Year: 2002 Source: J Control Release PMID: 11853922 DOI: 10.1016/s0168-3659(01)00532-6
Numerous familial, non-Mendelian (i.e., complex) diseases have been screened by linkage analysis for regions harboring susceptibility genes. Except for rare, high-penetrance syndromes showing Mendelian inheritance, such as BRCA1 and BRCA2, most attempts have failed to produce replicable linkage findings. For example, in multiple sclerosis and other complex diseases, there have …
Toxicity of mycophenolate mofetil in patients with inflammatory bowel disease
Publication Year: 2002 Source: Inflamm Bowel Dis PMID: 11854606 DOI: 10.1097/00054725-200203000-00004
OBJECTIVE: Supportive-expressive (SE) group psychotherapy is designed to be applicable to medically ill populations. In this open trial, SE therapy was adapted for use in treating inflammatory bowel disease (IBD). METHOD: Thirty subjects with Crohn's disease (CD) or ulcerative colitis (UC) were enrolled in 4 psychotherapy groups. Each group met …
Management of internal fistulas in Crohn's disease
Publication Year: 2002 Source: Inflamm Bowel Dis PMID: 11854609 DOI: 10.1097/00054725-200203000-00007
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Etiopathogenesis of inflammatory bowel disease: the importance of the pediatric perspective
Publication Year: 2002 Source: Inflamm Bowel Dis PMID: 11854610 DOI: 10.1097/00054725-200203000-00008
A female patient with Crohn's disease developed an septic osteoarticular involvement of the left clavicle and sterno- and acromioclavicular regions. Repeated surgical revisions combined with a broad-spectrum antimicrobial treatment could not prevent the progress of the disease. However, the patient started to improve after the diagnosis of the SAPHO (synovitis, …
Application of genome-wide gene expression profiling by high-density DNA arrays to the treatment and study of inflammatory bowel disease
Publication Year: 2002 Source: Inflamm Bowel Dis PMID: 11854614 DOI: 10.1097/00054725-200203000-00012
Prednisolone (PD), a typical glucocorticoid, has been widely used for the treatment of inflammatory bowel disease (IBD). However, when PD is administered orally, a large amount of the drug is absorbed from the upper gastrointestinal (GI) tract and causes systemic side effects. In this study, the anti-inflammatory effect and systemic …
The immunology of mucosal models of inflammation
Publication Year: 2002 Source: Annu Rev Immunol PMID: 11861611 DOI: 10.1146/annurev.immunol.20.100301.064816
PURPOSE: To gain recent epidemiologic information about inflammatory bowel disease in The Netherlands, a prospective study over four years (1991-1995) was performed. METHODS: The incidence of inflammatory bowel disease and its subgroups was examined using standardized reports of newly diagnosed patients. A separate study compared the Inflammatory Bowel Disease Registration …
Mutation detection and physical mapping of the CD11 gene cluster in association with inflammatory bowel disease
Publication Year: 2002 Source: Immunogenetics PMID: 11862384 DOI: 10.1007/s00251-001-0411-y
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Cortical mapping of visceral pain in patients with GI disorders using functional magnetic resonance imaging
Publication Year: 2002 Source: Am J Gastroenterol PMID: 11866268 DOI: 10.1111/j.1572-0241.2002.05464.x
BACKGROUND: Inflammatory bowel disease (IBD) is characterised by infiltration of inflamed mucosal regions with CD4(+) T lymphocytes and other mononuclear cells. Interleukin (IL)-16 exerts a strong chemoattractant activity on CD4(+) cells. Moreover, IL-16 activates expression and production of proinflammatory cytokines such as IL-1beta, IL-6, IL-15, and tumour necrosis factor alpha …
Alterations in pulmonary function in inflammatory bowel disease are frequent and persist during remission
Publication Year: 2002 Source: Am J Gastroenterol PMID: 11866276 DOI: 10.1111/j.1572-0241.2002.05473.x
BACKGROUND: Musculoskeletal disorders are the most common extra-intestinal manifestation of inflammatory bowel disease (IBD). Wide ranges of prevalence have been reported depending on the criteria used to define spondylarthropathy and on the selection of patients. We aimed to evaluate the prevalence and clinical spectrum of musculoskeletal manifestations in an inception …
Quality of life in inflammatory bowel disease in remission: the impact of IBS-like symptoms and associated psychological factors
Publication Year: 2002 Source: Am J Gastroenterol PMID: 11866278 DOI: 10.1111/j.1572-0241.2002.05475.x
OBJECTIVE: The aim of this study was to determine the prevalence of the major extraintestinal manifestations of inflammatory bowel disease (IBD) and their relation to disease diagnosis and gender. METHODS: We used the population-based University of Manitoba IBD Database, which includes longitudinal files on all subjects of all health system …
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