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N-3 fatty acids for the treatment of inflammatory bowel diseases
Publication Year: 2002 Source: Proc Nutr Soc PMID: 12296296 DOI: 10.1079/pns2002171
OBJECTIVE: Various antimicrobial peptides such as defensins are part of innate immunity and contribute to the intestinal barrier that may be defective in inflammatory bowel disease (IBD). This study investigated beta-defensin mRNA and peptide expression in the colon from controls and patients with Crohn's disease, ulcerative colitis or unspecific colitis …
Functional relevance of soluble TNF-alpha, transmembrane TNF-alpha and TNF-signal transduction in gastrointestinal diseases with special reference to inflammatory bowel diseases
Publication Year: 2002 Source: Z Gastroenterol PMID: 12297983 DOI: 10.1055/s-2002-33418
OBJECTIVE: This prospective study evaluated a (99m)Tc antigranulocyte monoclonal antibody Fab' imaging agent (Sulesomab) in children with inflammatory bowel disease (IBD) newly diagnosed by colonoscopy. MATERIALS AND METHODS: Ten children (4 boys, 6 girls; mean age 14 years) with newly diagnosed Crohn's disease (n = 6) or ulcerative colitis (n …
Reversible vanishing bile duct syndrome induced by carbamazepine
Publication Year: 2002 Source: Eur J Gastroenterol Hepatol PMID: 12352223 DOI: 10.1097/00042737-200209000-00014
Amplified fragment length polymorphisms (AFLPs) are a widely used marker system: the technique is very cost-effective, easy and rapid, and reproducibly generates hundreds of markers. Unfortunately, AFLP alleles are typically scored as the presence or absence of a band and, thus, heterozygous and dominant homozygous genotypes cannot be distinguished. This …
Lactase deficiency: not more common in pediatric patients with inflammatory bowel disease than in patients with chronic abdominal pain
Publication Year: 2002 Source: J Pediatr Gastroenterol Nutr PMID: 12352524 DOI: 10.1097/00005176-200209000-00019
A total of 212 adult patients with infective diarrhoea and 27 with inflammatory bowel disease (IBD), admitted consecutively to an infectious disease unit, were studied in order to determine whether clinical features and laboratory measurements performed on admission identified cases of IBD. Long-standing diarrhoea, blood in the faeces, anaemia, leucocytosis, …
Differential susceptibility of multidrug resistance protein-1 deficient mice to DSS and TNBS-induced colitis
Publication Year: 2002 Source: Dig Dis Sci PMID: 12353855 DOI: 10.1023/a:1019629013945
Information on the age of a patient at disease onset, an important feature of complex diseases, is often collected in studies designed to map the disease genes. Penetrance-model-free methods, requiring no specification of penetrance functions, have been used extensively for detecting linkage and association between marker and disease loci. In …
Seroreactivities against Saccharomyces cerevisiae and Mycobacterium avium subsp. paratuberculosis p35 and p36 antigens in Crohn's disease patients
Publication Year: 2002 Source: Dig Dis Sci PMID: 12353858 DOI: 10.1023/a:1019685131692
The cytokines TNF and IL-1 have been implicated as mediators of the inflammatory processes in patients with inflammatory bowel disease (IBD). To investigate the role of these cytokines in mucosal inflammation we used anti-cytokine strategies in a mouse model of acute and chronic colitis. Mice which received 5% dextran sulphate …
Evidence for an inflammatory bowel disease locus on chromosome 3p26: linkage, transmission/disequilibrium and partitioning of linkage
Publication Year: 2002 Source: Hum Mol Genet PMID: 12354785 DOI: 10.1093/hmg/11.21.2599
BACKGROUND: Despite enormous progress in the medical treatment of inflammatory bowel diseases (IBD), corticosteroids still represent the most effective drugs in the management of acute IBD. Unfortunately, surgical intervention under concomitant therapy with corticosteroids is often complicated by impaired intestinal wound healing. Our aim was to assess the effects of …
[The Inflammatory Bowel Disease Stress Inventory (IBD-SI). A measure of psychosocial stress in patients with IBD]
Publication Year: 2002 Source: Psychother Psychosom Med Psychol PMID: 12355351 DOI: 10.1055/s-2002-34284
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Suspected inflammatory bowel disease--the clinical and economic impact of competing diagnostic strategies
Publication Year: 2002 Source: Am J Gastroenterol PMID: 12358253 DOI: 10.1111/j.1572-0241.2002.05988.x
BACKGROUND: Cytokines involved in inflammatory bowel disease (IBD) direct a predominantly cell-mediated T- helper-1 (Th1) immune response. The nonspecific anti-inflammatory treatment being used in the management of patients with IBD has not changed much since the 1970s and new therapeutic agents are keenly sought. Several compounds isolated from Allium sativum …
Molecular screening for colon cancer in inflammatory bowel disease
Publication Year: 2002 Source: Eur J Gastroenterol Hepatol PMID: 12362091 DOI: 10.1097/00042737-200210000-00001
The distribution of B27 alleles (B*2701-23) was characterized by PCR-SSP in ankylosing spondylitis and related spondyloarthropathies (SpA) in a sample of B27 positive patients from northern Spain. Six B27 alleles were identified: B*2705,02,03,07,08 and B*2713. B*2705 and 02 were the most common alleles in the SpA studied: ankylosing spondylitis (AS) …
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