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T cell activation causes diarrhea by increasing intestinal permeability and inhibiting epithelial Na+/K+-ATPase

Publication Year: 2002 Source: J Clin Invest PMID: 12464679 DOI: 10.1172/JCI15695

OBJECTIVES: The aims of this study were to assess bone metabolism in inflammatory bowel disease (IBD) patients and to evaluate potential differences between Crohn's disease (CD) and ulcerative colitis (UC) with respect to the mechanisms underlying bone loss in this group of diseases. DESIGN AND SETTING: This was a cross-sectional …

CTLA4 gene polymorphisms in Dutch and Chinese patients with inflammatory bowel disease

Publication Year: 2002 Source: Scand J Gastroenterol PMID: 12465728 DOI: 10.1080/003655202761020579

OBJECTIVE: To investigate the role of the gene NOD2 in susceptibility to, and clinical manifestations of, ankylosing spondylitis (AS). METHODS: A case-control study of NOD2 polymorphisms known to be associated with Crohn's disease (CD) (Pro(268)Ser, Arg(702)Trp, Gly(908)Arg, and Leu(1007)fsinsC) was performed in 229 cases of primary AS with no diagnosed …

Siblings and the risk of inflammatory bowel disease

Publication Year: 2002 Source: Scand J Gastroenterol PMID: 12465729 DOI: 10.1080/003655202761020588

BACKGROUND: Nowadays, severe deficiency of vitamin D is not a common finding in most developed countries. However, the prevalence of vitamin D insufficiency is relatively high and it can contribute to the descent of bone mass in osteoporosis risk populations. The objective of our study was to evaluate the prevalence …

A case of primary non-Hodgkin's lymphoma of the transverse colon presenting as inflammatory bowel disease

Publication Year: 2002 Source: Eur J Gastroenterol Hepatol PMID: 12468966 DOI: 10.1097/00042737-200212000-00020

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Inflammatory bowel disease: new insights into pathogenesis and treatment

Publication Year: 2002 Source: J Intern Med PMID: 12472908 DOI: 10.1046/j.1365-2796.2002.01067.x

In the preceding articles (Vol 8(13): 858-62; Vol 8(14): 926-30), the pathogenesis and aetiology of inflammatory bowel disease (IBD) and its medical and surgical treatment options were considered. In this final part of the series, the concept of an alliance between the patient with IBD and healthcare professionals in terms …

[Psychophysiology of visceral pain syndromes]

Publication Year: 2002 Source: Schmerz PMID: 12474032 DOI: 10.1007/s00482-002-0190-x

A rapid, deterministic method (DET) based on a recursive algorithm and a stochastic method based on Markov Chain Monte Carlo (MCMC) for calculating identity-by-descent (IBD) matrices conditional on multiple markers were compared using stochastic simulation. Precision was measured by the mean squared error (MSE) of the relationship coefficients in predicting …

Role of serology and routine laboratory tests in childhood inflammatory bowel disease

Publication Year: 2002 Source: Inflamm Bowel Dis PMID: 12479647 DOI: 10.1097/00054725-200209000-00003

Physicians who manage patients with inflammatory bowel disease (IBD) as well as the patients themselves need to know about the prospects of disability and the demand for rehabilitation associated with this chronic disease. The present study uses German social security statistics to characterize IBD patients undergoing a rehabilitation or having …

Potato glycoalkaloids adversely affect intestinal permeability and aggravate inflammatory bowel disease

Publication Year: 2002 Source: Inflamm Bowel Dis PMID: 12479649 DOI: 10.1097/00054725-200209000-00005

There have been suggestions that endothelins (ET-1, ET-2, ET-3) are involved in the pathogenesis of human inflammatory bowel disease (IBD). Furthermore, the non-selective endothelin receptor antagonist, bosentan, ameliorates colonic inflammation in TNBS colitis in rats. However, no studies have measured the tissue expression and release of endothelins in human IBD …

Genetic and environmental context determines the course of colitis developing in IL-10-deficient mice

Publication Year: 2002 Source: Inflamm Bowel Dis PMID: 12479650 DOI: 10.1097/00054725-200209000-00006

Thirty-one relatives of inflammatory bowel disease (IBD) patients referred to a specialist unit were assessed with the Camberwell Family Interview, and ratings of expressed emotion (EE) were made. These relatives were significantly less critical than relatives of psychiatric patients in previous studies (p<0.001). Outcome was assessed over a 12-month follow-up …

IBD5: the second Crohn's disease gene?

Publication Year: 2002 Source: Inflamm Bowel Dis PMID: 12479655 DOI: 10.1097/00054725-200209000-00012

Inflammatory bowel disease is a chronic condition with a pathogenic background that involves both genetic and environmental factors. Although important progress has been made regarding the former in the last decade, scarce knowledge is available for the latter. In this sense, smoking remains the most important environmental factor in IBD. …

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