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Inflammatory bowel disease: symptoms in the bowel and beyond
Publication Year: 2002 Source: Nurse Pract PMID: 12444363 DOI: 10.1097/00006205-200211000-00003
A group of 104 patients with inflammatory bowel disease (IBD) was followed longitudinally for 6 months. While anxiety and depression scores were influenced over time by changes in the level of disease activity, there was no significant change in alexithymia scores. The findings support the contention that alexithymia is a …
A method for incorporating ages at onset in affected sibpair linkage studies
Publication Year: 2002 Source: Hum Hered PMID: 12446982 DOI: 10.1159/000066693
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Cytokine/chemokine messenger-RNA expression profiles in ulcerative colitis and Crohn's disease
Publication Year: 2002 Source: Virchows Arch PMID: 12447682 DOI: 10.1007/s00428-002-0684-z
Inflammatory bowel disease (IBD) is characterized by a dysregulated intestinal immune response with elevated levels of the Th1 cytokines TNF, IL-12 and IFN-gamma. The luminal flora has been implicated as a major factor contributing to the initiation and perpetuation of chronic intestinal inflammation by as yet unknown mechanisms. Bacterial DNA …
In vivo detection of morphological and microvascular changes of the colon in association with colitis using fiberoptic confocal imaging (FOCI)
Publication Year: 2002 Source: Dig Dis Sci PMID: 12452374 DOI: 10.1023/a:1020631220599
To investigate the role of Reg Ialpha in human inflammatory bowel disease (IBD), we made two phage-displayed single chain variable fragment (scFv) libraries from rabbits immunized with recombinant or native human Reg Ialpha. After one to three rounds of panning, we were able to isolate phage-displaying scFvs, which bound to …
Prevalence of factor V G1691A (Leiden), prothrombin G20210A, and methylene tetrahydrofolate reductase C677T thrombophilic mutations in children with inflammatory bowel disease
Publication Year: 2002 Source: J Pediatr Gastroenterol Nutr PMID: 12454577 DOI: 10.1097/00005176-200211000-00008
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Using a genome-wide scan and meta-analysis to identify a novel IBD locus and confirm previously identified IBD loci
Publication Year: 2002 Source: Inflamm Bowel Dis PMID: 12454612 DOI: 10.1097/00054725-200211000-00001
GOALS: Our goals were to answer 2 questions: (1) Is the presentation of early-onset inflammatory bowel disease (IBD) similar to typical adolescent-onset IBD? (2) Is there variability in familial aggregation in childhood IBD? BACKGROUND: The phenotype of IBD in children under 5 years of age (early-onset) is poorly defined. Clinical …
The impact of inflammatory bowel disease on labor force participation: results of a population sampled case-control study
Publication Year: 2002 Source: Inflamm Bowel Dis PMID: 12454613 DOI: 10.1097/00054725-200211000-00002
Asthma is a complex disease, with an etiology that includes both genetic and environmental influences that may interact. The moderate heritability of asthma has led researchers to investigate its molecular genetic basis using both exploratory investigations of linkage via genome scans, as well as targeted studies of specific candidate genes. …
Inflammatory bowel disease in women: impact on relationship and sexual health
Publication Year: 2002 Source: Inflamm Bowel Dis PMID: 12454617 DOI: 10.1097/00054725-200211000-00006
The inflammatory bowel diseases (IBD; Crohn's disease, ulcerative colitis) are a collection of chronic idiopathic inflammatory disorders of the intestine and/or colon. Although the pathophysiology of IBD is not known with certainty, a growing body of experimental and clinical data suggests that chronic gut inflammation may result from a dysregulated …
The genesis of IBD genetics
Publication Year: 2002 Source: Gastroenterology PMID: 12454871 DOI: 10.1053/gast.2002.1232148
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Colonic inflammatory bowel disease. Medical therapies for colonic Crohn's disease and ulcerative colitis
Publication Year: 2002 Source: Postgrad Med PMID: 12462184 DOI: 10.3810/pgm.2002.11.1344
Most cases of inflammatory bowel disease (IBD) can be correctly labelled as Crohn's disease (CD) or ulcerative colitis (UC) with careful initial gross and microscopic examination of biopsy and resection specimens together with close clinical and radiological correlation. Until we understand more of the aetiology and immunology of IBD we …
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