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Oxidative stress and antioxidant capacity in patients with inflammatory bowel disease
Publication Year: 2002 Source: Clin Biochem PMID: 12493587 DOI: 10.1016/s0009-9120(02)00361-2
Inflammatory bowel diseases (IBD) are multifactorial disorders characterised by the host's inability to limit the inflammatory response to luminal antigens. The association of polymorphisms in the CARD15 gene with Crohn's disease (CD) demonstrates the relevance of activated transcription factor NF(kappa)B in mononuclear cells. Interleukin 11 (IL11) mediates anti-inflammatory effects and …
Diminished efficacy of colonic adaptation to lactulose occurs in patients with inflammatory bowel disease in remission
Publication Year: 2002 Source: Dig Dis Sci PMID: 12498306 DOI: 10.1023/a:1021034028295
OBJECTIVE: Mast cells are thought to participate in the pathogenesis of inflammatory bowel disease (IBD). In this study, urinary excretion of N-methylhistamine (UMH), a stable metabolite of the mast cell mediator histamine, was evaluated as an indicator of disease activity in patients with IBD. METHODS: Urinary excretion of UMH (microg/mmol …
Support for the presence of bipolar disorder susceptibility loci on chromosome 5: heterogeneity in a homogeneous population in Quebec
Publication Year: 2002 Source: Prog Neuropsychopharmacol Biol Psychiatry PMID: 12502013 DOI: 10.1016/s0278-5846(02)00266-x
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Recent developments in inflammatory bowel disease
Publication Year: 2002 Source: Med Clin North Am PMID: 12510462 DOI: 10.1016/s0025-7125(02)00085-8
Guo and Elston [Hum Hered 1999;49:112-118] developed a linkage information content (LIC) value to measure the informativeness of a marker for identity-by-descent (IBD) sharing status of relative pairs. LIC values were derived for five types of relative pairs: full sib, half sib, grandparent-grandchild, first cousin and avuncular. In this paper, …
Hepatic manifestations of gastrointestinal diseases. Inflammatory bowel disease, celiac disease, and Whipple's disease
Publication Year: 2002 Source: Clin Liver Dis PMID: 12516204 DOI: 10.1016/s1089-3261(02)00055-7
The management of perirectal disease in association with IBD requires an individual approach to the patient with combined medical and surgical therapy where appropriate. No matter what therapy is used, the main goal is to alleviate symptoms and cure the problem where possible. Before undertaking management it is crucial to …
Oral 5-aminosalicylic acid for maintenance of remission in ulcerative colitis
Publication Year: 2002 Source: Cochrane Database Syst Rev PMID: 12519547 DOI: 10.1002/14651858.CD000544
Update of doi: 10.1002/14651858.CD006792. BACKGROUND: Historically, corticosteroids have been the most commonly used class of medication for induction of remission in Crohn's disease (CD). Corticosteroids down regulate production of inflammatory cytokines and interfere with NF-kappaB production, thereby blunting inflammatory response. OBJECTIVES: The primary objective was to systematically review the efficacy …
Effects of duodenal seal oil administration in patients with inflammatory bowel disease
Publication Year: 2002 Source: Lipids PMID: 12530551 DOI: 10.1007/s11745-006-0983-2
BACKGROUND: Patients with inflammatory bowel disease (IBD) are at increased risk of developing osteopenia and osteoporosis. Our aim was to evaluate the current practices of examination, prevention and treatment of osteoporosis in IBD patients in a routine clinical setting. METHODS: A total of 154 consecutive patients with IBD (63 female, …
RDP58, a locally active TNF inhibitor, is effective in the dextran sulphate mouse model of chronic colitis
Publication Year: 2002 Source: Inflamm Res PMID: 12540016 DOI: 10.1007/pl00012423
It is generally believed that an early age at the onset of disease is associated with a stronger genetic component. Our aim here was to investigate both linkage and genetic heterogeneity of asthma, the latter corresponding to different genotype relative risks of a putative linked gene according to age at …
Role of microecology in chronic inflammatory bowel diseases
Publication Year: 2002 Source: Eur J Clin Nutr PMID: 12556945 DOI: 10.1038/sj.ejcn.1601662
An unsolved puzzle in IBD research is whether germs, genes, or a combination of the two with excessive immune responses to gut-associated bacteria explains the pathogenesis of UC and CD. Whatever the answer, there is little doubt that microbial factors are involved intimately in IBD pathogenesis. Although a long search …
The meaning of parental illness to children: the case of inflammatory bowel disease
Publication Year: 2002 Source: Child Care Health Dev PMID: 12568477 DOI: 10.1046/j.1365-2214.2002.00302.x
There is a paucity of randomized, controlled therapy studies of the extraintestinal manifestations of inflammatory bowel disease (IBD). Most current therapeutic approaches are empiric or based on approaches to therapy in other settings. In the past year anecdotal evidence has emerged for the use of therapies that neutralize tumor necrosis …
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