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Animal models of inflammatory bowel disease: an overview
Publication Year: 2002 Source: Pathobiology PMID: 12571415 DOI: 10.1159/000068143
Comment in Inflamm Bowel Dis. 2010 Dec;16(12):2180-1. BACKGROUND AND AIMS: Interleukin 17 (IL17) is now known to be involved in a number of chronic inflammatory disorders. However, the mechanisms regulating its production in inflammatory bowel disease (IBD) are still unclear. METHODS: Endoscopic biopsies or surgical specimens were taken from inflamed …
Neutrophil migration across the intestinal epithelial barrier--summary of in vitro data and description of a new transgenic mouse model with doxycycline-inducible interleukin-8 expression in intestinal epithelial cells
Publication Year: 2002 Source: Pathobiology PMID: 12571418 DOI: 10.1159/000068146
Since only scarce data are available on the immune response against heat shock proteins (HSP) in inflammatory bowel disease (IBD), we have measured with an ELISA method serum levels of IgG, IgA, and IgM antibodies to mycobacterial HSP65 and human HSP60 in 66 patients with Crohn's disease (CD), 42 patients …
Role of gamma delta T cells in inflammatory bowel disease
Publication Year: 2002 Source: Pathobiology PMID: 12571419 DOI: 10.1159/000068147
Comment in J Clin Gastroenterol. 2003 Feb;36(2):93-8. Inflamm Bowel Dis. 2004 May;10(3):329-30. BACKGROUND: Eosinophil accumulation and activation are characteristic features of inflammation in allergic diseases and in host defense against parasites. GOALS: To investigate the involvement of eosinophils in inflamed and noninflamed mucosa of patients with inflammatory bowel disease (IBD). …
Early events in the pathogenesis of a murine transfer colitis
Publication Year: 2002 Source: Pathobiology PMID: 12571420 DOI: 10.1159/000068148
A crucial step in the development of clinical trials to determine the efficacy of various therapies for inflammatory bowel disease (IBD) has been the creation of activity indices. This article reviews the major components and operating characteristics of clinical activity indices commonly used in randomized, controlled trials of IBD therapy. …
Anti-interleukin-18 therapy in murine models of inflammatory bowel disease
Publication Year: 2002 Source: Pathobiology PMID: 12571421 DOI: 10.1159/000068149
Many studies have indicated changes in neuropeptides in inflammatory bowel disease (IBD), but with contradictory results. Nerve growth factor also has a potential role in the maintenance of enteric nerves and may be associated with IBD. A quantitative immunohistochemical method was used to measure area density of immunoreactive nerves in …
Interleukin-12 antagonists as new therapeutic agents in inflammatory bowel disease
Publication Year: 2002 Source: Pathobiology PMID: 12571423 DOI: 10.1159/000068151
Chronic inflammatory bowel disease is a multifactorial disorder with two major clinical forms, Crohn's disease and ulcerative colitis. One of the potential susceptibility loci for inflammatory bowel disease (IBD2) was localized at 12q13-14 in the vicinity of the deoxyribonucleic acid marker D12S83 by linkage analysis. A candidate susceptibility gene for …
Functional involvement of CD44 variant 7 in gut immune response
Publication Year: 2002 Source: Pathobiology PMID: 12571424 DOI: 10.1159/000068152
Although the etiology of inflammatory bowel disease (IBD) is unknown, there is increasing evidence for the pivotal role played by tumor necrosis factor-alpha (TNF-alpha). Recent work has shown an increased concentration of TNF-alpha in both the bowel wall and in the stools of patients with IBD, and in children with …
Possible involvement of neutrophil elastase in impaired mucosal repair in patients with ulcerative colitis
Publication Year: 2002 Source: J Gastroenterol PMID: 12572862 DOI: 10.1007/BF03326409
BACKGROUND: Inhibition of NF-kappaB activation has been suggested as an anti-inflammatory treatment strategy in inflammatory bowel disease (IBD). However, NF-kappaB regulated genes like inducible nitric oxide synthase (iNOS) are also involved in cell survival mechanisms. METHODS: Review of the literature on NF-kappaB activation and iNOS induction in IBD. RESULTS: In …
Intestinal subepithelial myofibroblasts in inflammatory bowel diseases
Publication Year: 2002 Source: J Gastroenterol PMID: 12572863 DOI: 10.1007/BF03326410
BACKGROUND: Activin A modulates inflammation and repair in various tissues. The aim of this study was to characterize the effects of activin A on intestinal epithelial cell function and to evaluate a potential role in intestinal epithelial wound repair and inflammation. METHODS: The expression of activin A and its receptors …
Role of the innate immune system in the development of chronic colitis
Publication Year: 2002 Source: J Gastroenterol PMID: 12572864 DOI: 10.1007/BF03326411
Lymphocytic-plasmacytic enteritis (LPE) is a morphological diagnosis given to a type of infiltrative intestinal disease classified within the complex of idiopathic inflammatory bowel disease (IBD). The purpose of this retrospective study was to describe the details of breed, age and sex, clinical and clinicopathological findings and outcome of horses diagnosed …
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