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Polynitroxylated starch/TPL attenuates cachexia and increased epithelial permeability associated with TNBS colitis
Publication Year: 2002 Source: Inflammation PMID: 11936750 DOI: 10.1023/a:1014420327417
Comment in Gut. 2010 Nov;59(11):1452-3. BACKGROUND AND AIMS: O(6)-Methylguanine-DNA methyltransferase (MGMT) removes methyl adducts from O(6)-guanine. Known as methylation tolerance, selection for mismatch repair (MMR)-deficient cells that are unable to initiate lethal processing of O(6)-methylguanine-induced mismatches in DNA is observed in vitro as a consequence of MGMT deficiency. It was …
Circulating soluble vascular adhesion protein 1 in patients with inflammatory bowel disease
Publication Year: 2002 Source: Eur J Gastroenterol Hepatol PMID: 11943954 DOI: 10.1097/00042737-200204000-00012
BACKGROUND: Inflammatory bowel disease (IBD) is a chronic inflammation of the gastrointestinal tract of unknown aetiology, phenotypically categorized into ulcerative colitis (UC) and Crohn disease (CD). Genetic factors are of considerable importance in both. The genetic relationship between IBD and the interleukin-1 receptor antagonist and interleukin-1beta genes (IL-1RN, and IL-1B, …
A new, highly sensitive assay for C-reactive protein can aid the differentiation of inflammatory bowel disorders from constipation- and diarrhoea-predominant functional bowel disorders
Publication Year: 2002 Source: Eur J Gastroenterol Hepatol PMID: 11943955 DOI: 10.1097/00042737-200204000-00013
Bone loss in inflammatory bowel disease (IBD) is presumed to be mediated by inflammation. Increased levels of the multifunctional cytokine IL-6 in inflammatory diseases have been proposed to be the link in such "inflammation-mediated osteopenia." A recently described G/C polymorphism with an effect on transcription rate and plasma levels of …
Inflammatory bowel disease in mother or father and neonatal outcome
Publication Year: 2002 Source: Acta Paediatr PMID: 11952000 DOI: 10.1080/080352502317285126
Magnolia sieboldii ssp. japonica, distributed mainly in western Japan, is restricted to high elevation areas (1000-2000 m above sea level) and usually forms small isolated populations. Four microsatellite loci were assayed for 19 populations from six regions spanning the range of distribution, and the levels and distribution of genetic variation …
Influence of treatment on morphological features of mucosal inflammation
Publication Year: 2002 Source: Gut PMID: 11953331 DOI: 10.1136/gut.50.suppl_3.iii37
Comment in Gastroenterology. 2002 Jan;122(1):228-30. Gastroenterology. 2002 Sep;123(3):955; author reply 956. BACKGROUND & AIMS: Microorganisms that directly interact with the intestinal mucosa are obscured by fecal flora and poorly characterized. METHODS: We investigated the mucosal flora of washed colonoscopic biopsies of 305 patients with bowel inflammation and 40 controls. The …
Power and sample sizes for linkage with extreme sampling under an oligogenic model for quantitative traits
Publication Year: 2002 Source: Behav Genet PMID: 11958540 DOI: 10.1023/a:1014403827957
BACKGROUND: Although the pathogenesis of osteoporosis in inflammatory bowel disease (IBD) is not established, vitamin D deficiency and disturbances in calcium metabolism are thought to be of importance, especially in Crohn disease (CD). Vitamin D status is assessed and the relation between indices of calcium metabolism, including 25-hydroxyvitamin D and …
The effect of nonmalignant systemic disease on tolerance to radiation therapy
Publication Year: 2002 Source: Oncologist PMID: 11961197 DOI: 10.1634/theoncologist.7-2-136
Comment in Am J Gastroenterol. 2000 Nov;95(11):3024-6. OBJECTIVES: Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease of unknown origin that mostly affects male patients with inflammatory bowel disease (IBD). The immune system is believed to be involved in the etiology/pathogenesis as these patients present with several immunological disturbances. …
[Cost measurement based on a cost diary in patients with inflammatory bowel disease]
Publication Year: 2002 Source: Z Gastroenterol PMID: 11961730 DOI: 10.1055/s-2002-25153
HYPOTHESES: Health-related quality of life (HRQL) has been shown to improve dramatically shortly after surgery in patients with inflammatory bowel disease (IBD). Our hypotheses were that (1) improved HRQL would be maintained long term in patients after surgery for ulcerative colitis and (2) the improved HRQL in patients with Crohn …
The natural plant product tryptanthrin ameliorates dextran sodium sulfate-induced colitis in mice
Publication Year: 2002 Source: Int Immunopharmacol PMID: 11962735 DOI: 10.1016/s1567-5769(01)00206-5
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Total dose intravenous infusion of iron dextran for iron-deficiency anemia in children with inflammatory bowel disease
Publication Year: 2002 Source: J Pediatr Gastroenterol Nutr PMID: 11964953 DOI: 10.1097/00005176-200203000-00011
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