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Early studies on the safety and efficacy of thalidomide for symptomatic inflammatory bowel disease
Publication Year: 2002 Source: J Gastroenterol Hepatol PMID: 11966942 DOI: 10.1046/j.1440-1746.2002.02564.x
Perinuclear antineutrophil cytoplasmic antibodies (p-ANCA) directed against cytoplasmic proteins of neutrophils have been studied extensively in patients with systemic vasculitides. Recent data indicate that antineutrophil antibodies in sera from patients with chronic inflammatory bowel diseases (IBD) or autoimmune liver disorders, currently called 'atypical p-ANCA', recognize a nuclear target antigen, rendering …
Inflammatory bowel disease: is the intestine a Trojan horse?
Publication Year: 2002 Source: Sci Prog PMID: 11969118 DOI: 10.3184/003685002783238861
BACKGROUND: The production of nitric oxide (NO) is increased in ulcerative colitis, as shown by bioassays of NO synthase activity in mucosal biopsy specimens. We wanted to develop a less invasive method for measurement of NO directly in the rectum in patients with inflammatory bowel disease (IBD). METHODS: We studied …
Functional magnetic resonance imaging of the human cervical spinal cord with stimulation of different sensory dermatomes
Publication Year: 2002 Source: Magn Reson Imaging PMID: 11973024 DOI: 10.1016/s0730-725x(02)00468-x
This study assesses the potential for using mid-infrared (mid-IR) spectroscopy of dried serum films as the basis for the simultaneous quantitation of eight serum analytes: total protein, albumin, triglycerides, cholesterol, glucose, urea, creatinine and uric acid. Infrared transmission spectra were acquired for 300 serum samples, each analysed independently using accepted …
Considerations on study designs using the extreme sibpairs methods under multilocus oligogenic models
Publication Year: 2002 Source: Genetics PMID: 11973325 DOI: 10.1093/genetics/160.4.1733
Experiments in animal models have suggested a role for bacterial overgrowth in the caecum in the pathogenesis of extracolonic inflammation in IBD. The aim of this study was to identify patients with Crohn's disease who have undergone ileocaecal resection and to compare the incidence of new arthritic complications in these …
[Development of inflammatory bowel disease in a husband and wife]
Publication Year: 2002 Source: Gastroenterol Hepatol PMID: 11975872 DOI: 10.1016/s0210-5705(02)70253-7
The purpose of this study was to assess the reactions of people with IBD to foods consumed. A database was created to capture the season of data collection, the disease, the food, and the subject's reaction to each food. A 122-item food list was used. Sixty patients with IBD (n …
Inflammatory bowel disease
Publication Year: 2002 Source: Best Pract Res Clin Gastroenterol PMID: 11977930 DOI: 10.1053/bega.2001.0267
MicroRNAs (miRNAs) are small, noncoding RNAs that regulate gene and protein expression. miRNAs are critical to a normal immune response and have altered expression in multiple immune-mediated disorders. This emerging role of miRNAs in the pathogenesis of multiple disease states has led to investigations into miRNA expression profiles in inflammatory …
Increased expression of extracellular glutathione peroxidase in mice with dextran sodium sulfate-induced experimental colitis
Publication Year: 2002 Source: Pediatr Res PMID: 11978890 DOI: 10.1203/00006450-200205000-00016
BACKGROUND: To evaluate the use of low-field magnetic resonance imaging (MRI) in active inflammatory bowel disease (IBD). METHODS: MRI was executed in a consecutive cohort of 28 patients with Crohn disease (CD) and in 17 with ulcerative colitis (UC) prior to glucocorticoid treatment (1 mg prednisolone orally/kg body weight/day). MRI …
Use of complementary therapies by patients with IBD may indicate psychosocial distress
Publication Year: 2002 Source: Inflamm Bowel Dis PMID: 11979137 DOI: 10.1097/00054725-200205000-00003
The assessment of inflammatory activity in intestinal disease in man can be done using a variety of different techniques. These range from the use of non-invasive acute phase inflammatory markers measured in plasma such as C reactive protein (CRP) and the erythrocyte sedimentation rate (ESR) (both of which give an …
Successful treatment of an acute flare of steroid-resistant Crohn's colitis during pregnancy with unfractionated heparin
Publication Year: 2002 Source: Inflamm Bowel Dis PMID: 11979140 DOI: 10.1097/00054725-200205000-00006
Inflammatory bowel disease (IBD) rarely occurs de novo after liver transplantation, and when it does usually presents as ulcerative colitis in patients transplanted for primary sclerosing cholangitis. We present two patients who developed de novo Crohn's colitis two and three years after liver transplant for primary biliary cirrhosis (PBC) and …
Recent advances in understanding NF-kappaB regulation
Publication Year: 2002 Source: Inflamm Bowel Dis PMID: 11979142 DOI: 10.1097/00054725-200205000-00008
The present study examines the effect of dexamethasone treatment on the intensity of changes in T2-weighted and diffusion-weighted (DW) magnetic resonance images occurring in infant rats during and after cerebral hypoxia-ischemia. The right carotid artery was occluded under isoflurane anesthesia in 7-day-old rats and images were acquired in sedated animals …
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