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Inflammatory bowel disease: developing a short disease specific scale to measure health related quality of life
Publication Year: 2002 Source: Int J Nurs Stud PMID: 12100869 DOI: 10.1016/s0020-7489(01)00042-6
Treatment options for inflammatory bowel disease (IBD) reflect a continuing shift from empiricism to strategies based on improved understanding of the pathophysiology of disease. In susceptible individuals, IBD appears to be the result of defective regulation of mucosal immune interactions with the enteric microflora. This has prompted research directed at …
Amelioration of dextran sulfate sodium-induced colitis by anti-macrophage migration inhibitory factor antibody in mice
Publication Year: 2002 Source: Gastroenterology PMID: 12105854 DOI: 10.1053/gast.2002.34236
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[Prevalence of vitamin D deficiency in populations at risk for osteoporosis: impact on bone integrity]
Publication Year: 2002 Source: Med Clin (Barc) PMID: 12106535 DOI: 10.1016/s0025-7753(02)73327-7
Comment in J Gastroenterol Hepatol. 2002 Sep;17(9):935-7. BACKGROUND AND AIM: T-cell activation, mediated by the interaction with major histocompatibility complex (MHC)-peptide complexes and B7 costimulatory molecules on antigen-presenting cells, is an essential event in the pathogenesis of inflammatory bowel disease (IBD). We investigated the expression of B7 costimulatory molecules on …
Interleukin-1beta converting enzyme (caspase-1) in intestinal inflammation
Publication Year: 2002 Source: Biochem Pharmacol PMID: 12106600 DOI: 10.1016/s0006-2952(02)01064-x
No difference in the number of serious adverse events was reported in previous clinical trials in rheumatoid arthritis (RA) and inflammatory bowel disease (IBD) patients treated with TNF-alpha blockade, but a patient died because of disseminated tuberculosis. A tuberculosis reactivation in a patient with IBD and anti-TNF-alpha treatment has been …
Powerful regression-based quantitative-trait linkage analysis of general pedigrees
Publication Year: 2002 Source: Am J Hum Genet PMID: 12111667 DOI: 10.1086/341560
BACKGROUND: Most incidence studies of ulcerative colitis (UC) and Crohn disease (CD) have dealt with adults and there are have been few population-based prospective studies of the incidence of inflammatory bowel disease (IBD) in children. The aim of this study was to determine the incidence after re-evaluation of the diagnosis …
Effect of adrenergic stimulation on Rb(+) uptake in normal and ischemic areas of isolated pig hearts: (87)Rb MRI study
Publication Year: 2002 Source: Magn Reson Med PMID: 12111927 DOI: 10.1002/mrm.10187
87Rb MR imaging and spectroscopy were used to study the effects of ischemia on the properties of K(+) in cardiac tissue. Isolated pig and rat hearts perfused by the Langendorff method with Krebs-Henseleit buffer were preloaded with Rb(+). Ischemia (Isc) was induced by 120-min occlusion of the left anterior descending …
Role of NOD2 variants in spondylarthritis
Publication Year: 2002 Source: Arthritis Rheum PMID: 12115195 DOI: 10.1002/art.10329
IL-10 is an important regulatory cytokine in the mucosal immune system, as supported by the fact that mice deficient in IL-10 spontaneously develop Crohn's disease-like colitis. An aberrant, Th1-driven CD4(+) T-cell response to enteric bacteria seems to be important in the pathogenesis of this murine colitis. However, no specific bacteria …
CpG motifs of bacterial DNA exacerbate colitis of dextran sulfate sodium-treated mice
Publication Year: 2002 Source: Eur J Immunol PMID: 12115630 DOI: 10.1002/1521-4141(200207)32:7<2084::AID-IMMU2084>3.0.CO;2-Q
Extracellular glutathione peroxidase (E-GPx) is a selenoenzyme that reduces hydrogen peroxide and organic peroxides. All plasma glutathione peroxidase (GPx) activity in humans is attributable to E-GPx. The gastrointestinal (GI) tract also synthesizes and secretes E-GPx into the extracellular milieu. Endogenously generated oxidants have been implicated in inflammatory bowel disease (IBD). …
Turner syndrome associated with acquired von Willebrand disease, primary biliary cirrhosis, and inflammatory bowel disease
Publication Year: 2002 Source: Am J Hematol PMID: 12116986 DOI: 10.1002/ajh.10120
BACKGROUND: The CC-chemokines eotaxin and eotaxin-2, produced by epithelial and phagocytic cells, are potent and selective chemoattractants for eosinophils and basophils. The eosinophil is a potent inflammatory cell thought to play an important role in the pathogenesis of inflammatory bowel disease (IBD). In this study we investigated the serum concentrations …
New steroids for IBD: progress report
Publication Year: 2002 Source: Gut PMID: 12117876 DOI: 10.1136/gut.51.2.182
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