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In siblings with similar genetic susceptibility for inflammatory bowel disease, smokers tend to develop Crohn's disease and non-smokers develop ulcerative colitis
Publication Year: 2002 Source: Gut PMID: 12077086 DOI: 10.1136/gut.51.1.21
BACKGROUND: Although the etiology of inflammatory bowel disease (IBD) is unknown, there is increasing evidence that genetic predisposition plays a major etiologic role. To provide the framework for gene identification using a positional cloning approach, ascertainment of families with multiple affected members and careful documentation of pedigrees are essential. OBJECTIVE: …
Forecast for using metabolite measurements in the dosing of azathioprine or 6-mercaptopurine for IBD patients: "partly cloudy"
Publication Year: 2002 Source: Gastroenterology PMID: 12078667 DOI: 10.1016/s0016-5085(02)70022-x
Not found
Body composition in patients with an ileostomy and inflammatory bowel disease: validation of bio-electric impedance spectroscopy (BIS)
Publication Year: 2002 Source: Eur J Clin Nutr PMID: 12080410 DOI: 10.1038/sj.ejcn.1601378
OBJECTIVE: Associations between HLA-DR genotypes and susceptibility to Crohn's disease (CD) have been reported. However, it is not known whether certain HLA-DR genotypes or IL-1ra gene polymorphism are associated with responsiveness to treatment or different clinical patterns of disease. DESIGN/SETTING: In a large, randomized, controlled multicentre trial, 318 patients with …
Mast cells and inflammatory mediators in chronic ulcerative colitis
Publication Year: 2002 Source: Acta Histochem PMID: 12086339 DOI: 10.1078/0065-1281-00641
We investigated a variety of methods for pooling data from eight data sets (n = 5,424 subjects) to validate evidence for linkage of markers in the cytokine cluster on chromosome 5q31-33 to asthma and asthma-associated phenotypes. Chromosome 5 markers were integrated into current genetic linkage and physical maps, and a …
A recursive procedure to compute the gametic relationship matrix and its inverse for marked QTL clusters
Publication Year: 2002 Source: Genes Genet Syst PMID: 12087195 DOI: 10.1266/ggs.77.123
The peak age ranges for pregnancy and inflammatory bowel disease (IBD) coincide, and many women develop IBD during their reproductive years. This contribution reviews the major studies on the subject, and is sub-divided into two broad considerations: the effects of the disease on fertility, pregnancy and other factors related to …
Treatment of inflammatory bowel disease in the elderly: an update
Publication Year: 2002 Source: Drugs Aging PMID: 12093322 DOI: 10.2165/00002512-200219050-00004
BACKGROUND: The sensitivity of assays for antineutrophil cytoplasmic antibody (ANCA), anti-Saccharomyces cerevisiae antibody (ASCA), and antipancreatic antibody (PAB) in different laboratories is unknown. Likewise, the sensitivity and diagnostic usefulness of these assays in patients with inflammatory bowel disease (IBD) in the community is unknown. METHODS: An incidence cohort of 290 …
Focally enhanced gastritis in children with Crohn's disease and ulcerative colitis
Publication Year: 2002 Source: Am J Gastroenterol PMID: 12094859 DOI: 10.1111/j.1572-0241.2002.05785.x
OBJECTIVE: Cost diaries administered by patients have been used as a method to measure costs for different diseases. Our aim was to test the application of a patient cost diary in patients with inflammatory bowel disease (IBD) and to measure disease specific resource utilization and costs. PATIENTS AND METHODS: A …
Assessing the quality of life of household members of patients with inflammatory bowel disease: development and validation of a specific questionnaire
Publication Year: 2002 Source: Am J Gastroenterol PMID: 12094861 DOI: 10.1111/j.1572-0241.2002.05684.x
The cause of mucosal injury in inflammatory bowel disease (IBD) is not clear but likely involves infectious agents or other toxins followed by an abnormal immune response in genetically susceptible individuals. The inflammatory cytokines appear to play a key role in both the susceptibility of some individuals and the tissue …
Elevated serum eotaxin levels in patients with inflammatory bowel disease
Publication Year: 2002 Source: Am J Gastroenterol PMID: 12094864 DOI: 10.1111/j.1572-0241.2002.05687.x
Not found
beta7 Integrin expression is not required for the localization of T cells to the intestine and colitis pathogenesis
Publication Year: 2002 Source: Clin Exp Immunol PMID: 12100020 DOI: 10.1046/j.1365-2249.2002.01892.x
Although some animal models suggest an involvement of CD4 T cells reactive to luminal microbial antigen(s) for the pathogenesis of inflammatory bowel diseases (IBD), direct linkage between microflora-driven clonal expansion of CD4 T cells and the development of colitis has not been well studied. Here, BALB/c and SCID mice were …
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