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Factors affecting surgical risk in elderly patients with inflammatory bowel disease
Publication Year: 2002 Source: J Gastrointest Surg PMID: 12127128 DOI: 10.1016/s1091-255x(01)00060-9
Interleukin (IL)-10 plays an important role in immune regulation in the intestine. Immune deregulation is suggested in the pathogenesis of inflammatory bowel disease (IBD). This study aims to elucidate the role of IL-23 in the suppression of IL-10 in the IBD intestinal mucosa. Surgically removed colon specimens were obtained from …
Providing disease-related information worsens health-related quality of life in inflammatory bowel disease
Publication Year: 2002 Source: Inflamm Bowel Dis PMID: 12131610 DOI: 10.1097/00054725-200207000-00005
BACKGROUND: Oxidative stress is believed to play a key role in the pathogenesis of inflammatory bowel disease (IBD)-related intestinal damage. Circulating antioxidants may have a role to play in preventing free radical-mediated tissue injury. METHODS: Plasma vitamin A, E and carotenoid concentrations, leukocytic genomic damage and 8-hydroxy-deoxy-guanosine (8-OHdG) concentration were …
Are parents able to rate the symptoms and quality of life of their offspring with IBD?
Publication Year: 2002 Source: Inflamm Bowel Dis PMID: 12131611 DOI: 10.1097/00054725-200207000-00006
The chronic inflammatory bowel diseases (IBDs)-Crohn disease (CD) and ulcerative colitis (UC)-are idiopathic, inflammatory disorders of the gastrointestinal tract. These conditions have a peak incidence in early adulthood and a combined prevalence of approximately 100-200/100,000. Although the etiology of IBD is multifactorial, a significant genetic contribution to disease susceptibility is …
Antiadhesion molecule therapy in inflammatory bowel disease
Publication Year: 2002 Source: Inflamm Bowel Dis PMID: 12131614 DOI: 10.1097/00054725-200207000-00009
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Isolation and characterization of rabbit single chain antibodies to human Reg Ialpha protein
Publication Year: 2002 Source: J Immunol Methods PMID: 12133637 DOI: 10.1016/s0022-1759(02)00117-5
Anorexia is a major complication of inflammatory bowel disease (IBD). We postulated that chronic intestinal inflammation with increased proinflammatory cytokines elevates serum leptin concentration, thereby contributing to anorexia. This hypothesis was studied in interleukin-2-deficient (IL-2(-/-)) mice, a model of IBD with elevated proinflammatory cytokine production. IL-2(-/-), wild-type pair-fed and wild-type …
Colorectal cancer in inflammatory bowel disease: molecular and clinical features
Publication Year: 2002 Source: Gastroenterol Clin North Am PMID: 12134618 DOI: 10.1016/s0889-8553(02)00014-6
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A new method for the quantification of neutrophil and eosinophil cationic proteins in feces: establishment of normal levels and clinical application in patients with inflammatory bowel disease
Publication Year: 2002 Source: Am J Gastroenterol PMID: 12135031 DOI: 10.1111/j.1572-0241.2002.05837.x
BACKGROUND: It has recently been suggested that Crohn's Disease (CD) is associated with an exaggerated T helper 1 cytokine response as manifest by increased production of interleukin-12 (IL-12) and interferon-gamma (IFN-gamma). Epstein-Barr virus-induced gene 3 (EBI3) encodes a 34-kDa glycoprotein that is 27% identical to the p40 unit of IL-12 …
Assessment of hypothalamic-pituitary-adrenal axis function after corticosteroid therapy in inflammatory bowel disease
Publication Year: 2002 Source: Am J Gastroenterol PMID: 12135036 DOI: 10.1111/j.1572-0241.2002.05786.x
OBJECTIVE: Reduced bone mineral density (BMD) is common in patients with inflammatory bowel disease (IBD), but the factors associated with its longitudinal rate of change have not been established. We prospectively assessed the rate of change in BMD, and its association with biochemical markers of bone turnover. METHODS: Twenty-two patients …
A Swedish case-control network for studies of drug-induced morbidity--acute pancreatitis
Publication Year: 2002 Source: Eur J Clin Pharmacol PMID: 12136374 DOI: 10.1007/s00228-002-0471-4
We used quantitative PCR to investigate the expression of chemokines and chemokine receptors in two Th1-mediated murine models of inflammatory bowel disease (IBD). First, mRNA levels encoding the chemokines MIG, RANTES, lymphotactin, MIP-3alpha, TCA-3, TARC, MIP-3beta, LIX, MCP-1 and MIP-1beta and the receptors CCR4, CCR6 and CCR2 were significantly increased …
Review on the influence of stress on immune mediators, neuropeptides and hormones with relevance for inflammatory bowel disease
Publication Year: 2002 Source: Digestion PMID: 12138318 DOI: 10.1159/000064933
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