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IBD (Isolation by Distance): a program for analyses of isolation by distance
Publication Year: 2002 Source: J Hered PMID: 12140277 DOI: 10.1093/jhered/93.2.153
AIMS: Triggering receptor expressed on myeloid cells-1 (TREM-1) has been shown to play a crucial role in the propagation of inflammatory responses. Recent studies have reported that TREM-1 expression is up-regulated in patients with inflammatory bowel disease (IBD). Therefore, we investigated the associations between TREM-1 genetic polymorphisms and IBD development …
Genetic heterogeneity in schizophrenia II: conditional analyses of affected schizophrenia sibling pairs provide evidence for an interaction between markers on chromosome 8p and 14q
Publication Year: 2002 Source: Mol Psychiatry PMID: 12140791 DOI: 10.1038/sj.mp.4001045
Not found
Estimation of sib-pair IBD sharing and multipoint polymorphism information content by linear regression
Publication Year: 2002 Source: Behav Genet PMID: 12141782 DOI: 10.1023/a:1016073113019
Erratum in Dig Dis Sci 2001 Jun;46(6):1352. The propagation pattern of individual pressure waves in the gastroduodenal area in IBS is unexplored. We performed antroduodenojejunal manometry on 26 patients with IBS--13 with diarrhea predominant IBS (IBS-D) and 13 with constipation predominant IBS (IBS-C)--and 32 healthy controls. Neuropathic-like motor abnormalities were …
Impaired humoral immune response against mycobacterial 65-kDa heat shock protein (HSP65) in patients with inflammatory bowel disease
Publication Year: 2002 Source: Dig Dis Sci PMID: 12141797 DOI: 10.1023/a:1015882127674
An imbalance of T helper cell type 1 (Th1) versus type 2 (Th2) polarization in favor of Th1 cell subsets appears to be a key pathogenic mechanism in chronic inflammatory bowel disease (IBD), in particular in Crohn's disease. The interferon gamma-inducing factor interleukin (IL)-18 acts in strong synergism with the …
The present status and the recent development of the treatment for inflammatory bowel diseases: desirable effect of extracorporeal immunomodulation
Publication Year: 2002 Source: Ther Apher PMID: 12164801 DOI: 10.1046/j.1526-0968.2002.00445.x
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Clinical profile of primary sclerosing cholangitis in Singapore
Publication Year: 2002 Source: J Gastroenterol Hepatol PMID: 12164967 DOI: 10.1046/j.1440-1746.2002.02835.x
Measurements of luminal pH in the normal gastrointestinal tract have shown a progressive increase in pH from the duodenum to the terminal ileum, a decrease in the caecum, and then a slow rise along the colon to the rectum. Some data in patients with ulcerative colitis suggest a substantial reduction …
Detection of Chlamydia pneumoniae by polymerase chain reaction-enzyme immunoassay in intestinal mucosal biopsies from patients with inflammatory bowel disease and controls
Publication Year: 2002 Source: J Gastroenterol Hepatol PMID: 12167120 DOI: 10.1046/j.1440-1746.2002.02793.x
BACKGROUND AND AIMS: This study was performed to have a first-time assessment on the knowledge level of a population of inflammatory bowel disease (IBD) patients in a developing country like Iran and to identify their health information preferences. METHODS: One hundred over 18-year-old IBD patients presenting to an outpatient gastroenterology …
Human beta-defensin 2 but not beta-defensin 1 is expressed preferentially in colonic mucosa of inflammatory bowel disease
Publication Year: 2002 Source: Eur J Gastroenterol Hepatol PMID: 12169983 DOI: 10.1097/00042737-200207000-00006
Inflammatory bowel disease (IBD) is a multifactorial disorder, with both genetic and environmental factors contributing to the two clinical phenotypes of Crohn's disease (CD) and ulcerative colitis (UC). The underlying genetic model is thought to involve multiple genes with complex interactions between disease loci, and the NOD2 gene on chromosome …
Role of mucins in inflammatory bowel disease: important lessons from experimental models
Publication Year: 2002 Source: Eur J Gastroenterol Hepatol PMID: 12169985 DOI: 10.1097/00042737-200207000-00008
BACKGROUND: Complementary and alternative medicine (CAM) is used increasingly by patients with chronic diseases. We have assessed the use of CAM in general medicine and gastrointestinal outpatients focusing particularly on factors predisposing to its use in patients with inflammatory bowel disease (IBD). METHODS: 239 consecutive patients attending gastrointestinal and general …
Activation of signal transducer and activator of transcription (STAT) 1 in human chronic inflammatory bowel disease
Publication Year: 2002 Source: Gut PMID: 12171960 DOI: 10.1136/gut.51.3.379
Erratum in Microvasc Res 2001 May;61(3):291. Inflammatory bowel disease (IBD) is associated with Th1/Th2 cytokine dysregulation, leukocyte extravasation, and tissue edema, but the mechanisms for cytokine-mediated vascular dysfunction are not understood. To investigate how cytokines might control edema in IBD, we determined vascular permeability and IFN-gamma expression in two models …
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