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Blocking Smad7 restores TGF-beta1 signaling in chronic inflammatory bowel disease
Publication Year: 2001 Source: J Clin Invest PMID: 11518734 DOI: 10.1172/JCI12821
Comment in JAMA. 2011 Dec 7;306(21):2380-1. Inflamm Bowel Dis. 2012 Dec;18(12):2414-6. CONTEXT: Although tumor necrosis factor (TNF)-α antagonists are increasingly used in place of nonbiologic comparator medications, their safety profile remains incomplete. OBJECTIVES: To determine whether initiation of TNF-α antagonists compared with nonbiologic comparators is associated with an increased risk …
Corticosteroids impair intestinal epithelial wound repair mechanisms in vitro
Publication Year: 2001 Source: Scand J Gastroenterol PMID: 11521988 DOI: 10.1080/003655201750305495
Endogenously formed nitrogen and oxygen free radicals are believed to be involved in human cancer etiology. Plasma nitrate/nitrite originates from endogenous nitric oxide production in fasting humans, decrease in superoxide scavenger activity (SSA), and free sulfhydryl groups (SH) reflects the amount of superoxide anion generated, and nitrotyrosine is believed to …
Distribution and activation of eosinophils in inflammatory bowel disease using an improved immunohistochemical technique
Publication Year: 2001 Source: J Pathol PMID: 11523058 DOI: 10.1002/path.904
OBJECTIVES: Practice guidelines should improve care, but they are not routinely followed, in part because of lack of proven benefit. We evaluated the effect of introducing guidelines for inflammatory bowel disease (IBD) on practice variation and the IBD Quality of Life (IBDQ) score. METHODS: This was a prospective, controlled, cohort …
Bacterial superantigens: provocateurs of gut dysfunction and inflammation?
Publication Year: 2001 Source: Trends Immunol PMID: 11525940 DOI: 10.1016/s1471-4906(01)02000-2
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Replication and extension studies of inflammatory bowel disease susceptibility regions confirm linkage to chromosome 6p (IBD3)
Publication Year: 2001 Source: Eur J Hum Genet PMID: 11528509 DOI: 10.1038/sj.ejhg.5200687
BACKGROUND: Experiments were aimed to test the cross-reactivity of immune Th1 cells that mediate contact hypersensitivity (CHS) or inflammatory bowel disease (IBD) to TNP in the mouse. METHODS: CBA/J mice were immunized either epicutaneously or intrarectally with TNP and after appropriate time intervals were challenged with antigen in a crossed …
Effect of MOI ratio on the composition and yield of chimeric infectious bursal disease virus-like particles by baculovirus co-infection: deterministic predictions and experimental results
Publication Year: 2001 Source: Biotechnol Bioeng PMID: 11536133 DOI: 10.1002/bit.1170
Comment in Ann Intern Med. 2000 Nov 21;133(10):828-30. BACKGROUND: The clinical significance of the high prevalence of osteopenia in inflammatory bowel disease is unclear. OBJECTIVE: To determine whether persons with inflammatory bowel disease have increased incidence of fracture. DESIGN: Population-based matched cohort study. SETTING: Manitoba, Canada. PATIENTS: Patients with inflammatory …
Spin-echo versus gradient-echo fMRI with short echo times
Publication Year: 2001 Source: Magn Reson Imaging PMID: 11551723 DOI: 10.1016/s0730-725x(01)00392-7
Purified glucoamylase from Arachniotus citrinus was immobilized on polyacrylamide gel with 70% yield of immobilization. The immobilization improved the pH optima, temperature optima, values of K(m), V(max), and activation energy. Irreversible thermal denaturation studies of soluble and immobilized glucoamylase indicated that immobilization decreased the entropy and enthalpy of deactivation by …
Characterization of contrast changes in functional MRI of the human spinal cord at 1.5 T
Publication Year: 2001 Source: Magn Reson Imaging PMID: 11551724 DOI: 10.1016/s0730-725x(01)00409-x
Although the causes of inflammatory bowel disease currently are not fully understood, increasing evidence implicates cytokines as key factors in the development of this disorder. The rationale for cytokine-targeted therapy for inflammatory bowel disease has been refined significantly, and clinical studies have been initiated. Recent investigations have focused on transcription …
Molecular cloning of a Bacteroides caccae TonB-linked outer membrane protein identified by an inflammatory bowel disease marker antibody
Publication Year: 2001 Source: Infect Immun PMID: 11553542 DOI: 10.1128/IAI.69.10.6044-6054.2001
BACKGROUND: Inflammatory bowel disease (IBD) is hypothesized to result from stimulation of immune responses against resident intestinal bacteria within a genetically susceptible host. Mast cells may play a critical role in IBD pathogenesis, since they are typically located just beneath the intestinal mucosal barrier and can be activated by bacterial …
Depression and anxiety in people with inflammatory bowel disease
Publication Year: 2001 Source: J Epidemiol Community Health PMID: 11553654 DOI: 10.1136/jech.55.10.716
Eosinophils are a recognized feature of inflammatory bowel disease (IBD), but their tissue distribution and functional importance in Crohn's disease (CD) and ulcerative colitis (UC) remain obscure. This study describes an improved immunohistochemical protocol to identify eosinophils in full thickness bowel wall specimens of IBD (n=40) and their in situ …
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