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Ethnic differences in allelic associations of the interleukin-1 gene cluster in South African patients with inflammatory bowel disease (IBD) and in control individuals

Publication Year: 2001 Source: Immunogenetics PMID: 11220627 DOI: 10.1007/s002510000265

Mast cells can serve as a possible important source of cytokine production in inflamed tissue which can be regulated by stimuli different from those activating other immune system cells. To study the expression of specific genes in mast cells derived from small human colonic mucosal endoscopic biopsies, we first modified …

Measles-mumps-rubella and other measles-containing vaccines do not increase the risk for inflammatory bowel disease: a case-control study from the Vaccine Safety Datalink project

Publication Year: 2001 Source: Arch Pediatr Adolesc Med PMID: 11231801 DOI: 10.1001/archpedi.155.3.354

A link between inflammation of the colon in inflammatory bowel disease (IBD) and the increased risk of colon cancer in ulcerative colitis (UC) may be provided by growth factor receptor genes. Their expression may be altered in response to growth factors present in the mucosa, and this, in turn, may …

Inflammatory bowel disease in spouses and their offspring

Publication Year: 2001 Source: Gastroenterology PMID: 11231934 DOI: 10.1053/gast.2001.22574

BACKGROUND: A number of autoantibodies have been reported in inflammatory bowel disease (IBD). The aim of this study was to investigate to what extent sera from patients with IBD contain autoantibodies directed against normal human gastrointestinal mucosa. METHODS: Samples of sera from 50 patients with IBD and 50 healthy subjects …

Comparative study of ASCA (Anti-Saccharomyces cerevisiae antibody) assays in inflammatory bowel disease

Publication Year: 2001 Source: Gastroenterology PMID: 11231936 DOI: 10.1053/gast.2001.22546

Comment in Gut. 2000 Dec;47(6):746-7. Gut. 2001 Aug;49(2):311. BACKGROUND AND AIMS: Inflammatory bowel disease (IBD) includes ulcerative colitis and Crohn's disease, both of which are multifactorial diseases involving the interaction of genetic and environmental factors. A region on chromosome 12 centred around the marker locus D12S83 has previously been associated …

Evidence for inflammatory bowel disease of a susceptibility locus on the X chromosome

Publication Year: 2001 Source: Gastroenterology PMID: 11231937 DOI: 10.1053/gast.2001.22453

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Enhanced survival and mucosal repair after dextran sodium sulfate-induced colitis in transgenic mice that overexpress growth hormone

Publication Year: 2001 Source: Gastroenterology PMID: 11231946 DOI: 10.1053/gast.2001.22470

BACKGROUND & AIMS: The role of the interleukin (IL)-1 receptor antagonist (IL-1ra) in predisposing an individual to inflammatory bowel disease (IBD) is controversial. This study aimed to determine the association between intron 2 IL-1ra polymorphism and IBD by performing a multiethnic case-control study and to assess its functional significance. METHODS: …

The use of 1H magnetic resonance spectroscopy in inflammatory bowel diseases: distinguishing ulcerative colitis from Crohn's disease

Publication Year: 2001 Source: Am J Gastroenterol PMID: 11232688 DOI: 10.1111/j.1572-0241.2001.03523.x

Till about 3 decades ago, inflammatory bowel disease (IBD) was considered as non-existent in our country. However, since that time several reports of IBD, mainly ulcerative colitis have been published. More recently, Crohn's disease is also being reported from the country. This trend of UC appearing first in a population …

Anti-Saccharomyces cerevisiae mannan antibodies and antineutrophil cytoplasmic autoantibodies in Greek patients with inflammatory bowel disease

Publication Year: 2001 Source: Am J Gastroenterol PMID: 11232689 DOI: 10.1111/j.1572-0241.2001.03524.x

BACKGROUND: Antisecretory factor (AF), a 41 kDa cloned and sequenced protein, suppresses intestinal inflammation and hypersecretion in animals. Endogenous AF production can be induced by dietary modifications in several animal species, and this feed has been shown to reduce the incidence of diarrhoeal disease in weaning piglets. The role of …

Low mortality in ulcerative colitis and Crohn's disease in three regional centers in England

Publication Year: 2001 Source: Am J Gastroenterol PMID: 11232697 DOI: 10.1111/j.1572-0241.2001.03466.x

Comment in Gut. 2002 May;50(5):741-2. BACKGROUND AND AIMS: Intestinal epithelial cell derived antimicrobial peptides of the defensin family may play a major role in host defence against microorganisms. Our aims were to (i) isolate, characterise, and investigate the processing of human defensin 5 (HD-5) in normal Paneth cells and (ii) …

Inflammation location, but not type, determines the increase in TGF-beta1 and IGF-1 expression and collagen deposition in IBD intestine

Publication Year: 2001 Source: Inflamm Bowel Dis PMID: 11233656 DOI: 10.1097/00054725-200102000-00003

Erratum in Scand J Gastroenterol 2001 Jun;36(6):facing 561. Comment in Scand J Gastroenterol. 2001 Sep;36(9):1008. This review addresses the difficulty in interpreting the results of epidemiological studies in IBD and in making meaningful comparisons between studies. Both ulcerative colitis and Crohn disease appear to be more common in some industrialized …

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