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Intestinal luminal pH in inflammatory bowel disease: possible determinants and implications for therapy with aminosalicylates and other drugs
Publication Year: 2001 Source: Gut PMID: 11247905 DOI: 10.1136/gut.48.4.571
BACKGROUND/AIMS: In our experience with the acute murine dextran sodium sulphate (DSS) model of experimental colitis, we noted both interstrain and interanimal variations in daily water consumption. One might critically question whether observed differences in injuries are just a dose dependency phenomenon reflecting variations in DSS intake. To clarify this …
Cutaneous manifestations in inflammatory bowel disease
Publication Year: 2001 Source: Z Gastroenterol PMID: 11253504 DOI: 10.1055/s-2001-11153
BACKGROUND: The aim of this work was to determine in Brittany the incidence and main clinical pattern of inflammatory bowel disease (IBD) occurring during childhood. These data are compared to the previous epidemiologic data available from the Northern France registry or around the world. METHODS: Private and public Brittany gastroenterologists …
Tree-based recursive partitioning methods for subdividing sibpairs into relatively more homogeneous subgroups
Publication Year: 2001 Source: Genet Epidemiol PMID: 11255239 DOI: 10.1002/gepi.1
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Recent advances in inflammatory bowel disease
Publication Year: 2001 Source: Crit Rev Clin Lab Sci PMID: 11256517 DOI: 10.1080/20014091084173
Inflammatory bowel disease (IBD) is a chronic inflammatory disease that affects the gastrointestinal tract. Information obtained from a clinical history, physical exam, laboratory testing, imaging studies, and endoscopic evaluations must be combined to accurately diagnose IBD. Further testing often becomes necessary to evaluate symptom relapse in patients with an established …
Isolation by distance in the Atlantic cod, Gadus morhua, at large and small geographic scales
Publication Year: 2001 Source: Evolution PMID: 11263734 DOI: 10.1111/j.0014-3820.2001.tb01279.x
Comment in Gut. 2000 Jan;46(1):6-7. Gut. 2000 Dec;47(6):870-1. BACKGROUND: Crohn's disease is a familial disorder, and antiglycan antibodies to the cell wall mannan of Saccharomyces cerevisiae (ASCA) are highly correlated with Crohn's disease. AIMS: To determine whether there is a familial pattern for expression of serum levels of anti-mannan Ig, …
Inhibition of nitric oxide synthesis by aminoguanidine increases intestinal damage in the acute phase of rat TNB-colitis
Publication Year: 2001 Source: Eur J Clin Invest PMID: 11264651 DOI: 10.1046/j.1365-2362.2001.00802.x
Genetic isolation by distance (IBD) has rarely been described in marine species with high potential for dispersal at both the larval and adult life-history stages. Here, we report significant relationships between inferred levels of gene flow and geographic distance in the Atlantic cod, Gadus morhua, at 10 nuclear restriction-fragment-length-polymorphism (RFLP) …
Turbo probiotics for IBD
Publication Year: 2001 Source: Gastroenterology PMID: 11266396 DOI: 10.1016/s0016-5085(01)87910-5
Transgenic rats with high expression of HLA-B27 and human β(2) -microglobulin (B27TR) develop a multisystem inflammatory disease resembling human inflammatory bowel disease (IBD) and spondyloarthropaties (SpA). Tumour necrosis factor α (TNF-α) has a crucial role in sustaining chronic inflammation in the gut and joints. The aim of this work was …
Inflammatory bowel disease
Publication Year: 2001 Source: Endoscopy PMID: 11272216 DOI: 10.1055/s-2001-11668
It has been claimed that pyoderma gangrenosum (PG) lesions may contain granulomatous foci when associated with Crohn's disease. To test this assertion, we obtained clinical histories and archived cutaneous biopsies from 34 PG patients. Thirteen of these patients had inflammatory bowel disease (IBD). Immunostaining with PGM1, a macrophage marker, revealed …
Regulation of human CLC-3 channels by multifunctional Ca2+/calmodulin-dependent protein kinase
Publication Year: 2001 Source: J Biol Chem PMID: 11274166 DOI: 10.1074/jbc.M009376200
OBJECTIVE: The present work was designed to study the myocardial perfusion and energy metabolism during retrograde cardioplegia performed with different methods, including deep coronary sinus cardioplegia, coronary sinus orifice cardioplegia, and right atrial cardioplegia. METHODS: Isolated pig hearts were subjected to antegrade cardioplegia, right atrial cardioplegia, deep coronary sinus cardioplegia, …
Diagnostic value of anti-Saccharomyces cerevisiae and antineutrophil cytoplasmic autoantibodies in inflammatory bowel disease
Publication Year: 2001 Source: Am J Gastroenterol PMID: 11280542 DOI: 10.1111/j.1572-0241.2001.03613.x
OBJECTIVE: Glucocorticoids are widely used in the treatment of inflammatory bowel disease (IBD). Up- and down-regulated expression of glucocorticoid receptors (GR) has been reported for different chronic inflammatory diseases. The aim of this study was to investigate the expression of GR and their apparent dissociation constant (Kd) in patients with …
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