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Clinical utility of serodiagnostic testing in suspected pediatric inflammatory bowel disease
Publication Year: 2001 Source: Am J Gastroenterol PMID: 11280547 DOI: 10.1111/j.1572-0241.2001.03618.x
BACKGROUND: The course of inflammatory bowel diseases (IBD) has mainly been studied using different methods in single patient cohorts. The aim of the present study was to assess clinical aspects of disease outcome in a population-based cohort of IBD patients over a 4-year period in multiple centres across Europe. METHODS: …
VEGF, basic-FGF, and TGF-beta in Crohn's disease and ulcerative colitis: a novel mechanism of chronic intestinal inflammation
Publication Year: 2001 Source: Am J Gastroenterol PMID: 11280558 DOI: 10.1111/j.1572-0241.2001.03527.x
BACKGROUND: Patients with inflammatory bowel disease (IBD) have a high prevalence of osteoporosis. A number of studies have found that corticosteroid use is associated with the development of osteoporosis in these patients. Calcium supplementation may be of benefit in corticosteroid-induced osteoporosis and calcium may be a nutrient that patients with …
CTLA4 gene polymorphisms are associated with, and linked to, insulin-dependent diabetes mellitus in a Russian population
Publication Year: 2001 Source: BMC Genet PMID: 11286636 DOI: 10.1186/1471-2156-2-6
BACKGROUND: The present experimental study was carried out to determine variations in bilirubin and lipid metabolism in obstructive jaundice after external biliary drainage alone and in combination with intraintestinal administration of the drained bile. MATERIALS AND METHODS: Variations in lipid and bilirubin metabolism were studied in adult mongrel dogs with …
Regulation of T-cell apoptosis in inflammatory bowel disease: to die or not to die, that is the mucosal question
Publication Year: 2001 Source: Trends Immunol PMID: 11286687 DOI: 10.1016/s1471-4906(00)01798-1
C3H/HeJBir is a substrain of C3H/HeJ mice that was generated by selective breeding for the phenotype of spontaneous colitis. These mice show increased B cell and T cell reactivity to antigens of the enteric bacterial flora. CD4+ T cells from this strain cause colitis, when activated by enteric bacterial antigens …
Upregulation of Reg 1alpha and GW112 in the epithelium of inflamed colonic mucosa
Publication Year: 2001 Source: Gut PMID: 11302958 DOI: 10.1136/gut.48.5.623
BACKGROUND: Decreased bone mineral density (BMD) is common in Western patients with inflammatory bowel disease (IBD). However, BMD has never been studied in Asia where the demographic and socio-economic status are different from the West. The aim of this study was to investigate the prevalence and mechanisms of osteopenia in …
No evidence of persistent mumps virus infection in inflammatory bowel disease
Publication Year: 2001 Source: Gut PMID: 11302960 DOI: 10.1136/gut.48.5.637
OBJECTIVE: To assess body hydration and the distribution of the body water compartments in defined populations of patients with inflammatory bowel disease (IBD) compared with those of matched healthy controls. SUBJECTS: Fifty-two patients with IBD at time of diagnosis (20 patients with Crohn's disease (CD-new) and 32 patients with ulcerative …
Utilisation of erythrocyte 6-thioguanine metabolite levels to optimise azathioprine therapy in patients with inflammatory bowel disease
Publication Year: 2001 Source: Gut PMID: 11302961 DOI: 10.1136/gut.48.5.642
Inflammatory bowel disease (IBD) is characterized by oxidative and nitrosative stress, leukocyte infiltration, and up-regulation of intercellular adhesion molecule 1 (ICAM-1) expression in the colon. The aim of this study was to examine the effects of the pineal secretory product melatonin in rats subjected to experimental colitis. Colitis was induced …
International collaboration provides convincing linkage replication in complex disease through analysis of a large pooled data set: Crohn disease and chromosome 16
Publication Year: 2001 Source: Am J Hum Genet PMID: 11309682 DOI: 10.1086/320119
A dysregulated local immune reaction with unbalanced cytokine expression seems essential in inflammatory bowel disease (IBD), i.e. ulcerative colitis (UC) and Crohn's disease (CD). Since the roles of interleukin (IL-)13 and IL-15 remain unclear, this study aimed at studying intestinal expression of IL-13 and IL-15 in IBD. METHODS: In colonic …
Ulcerative proctitis, rectal prolapse, and intestinal pseudo-obstruction in transgenic mice overexpressing hepatocyte growth factor/scatter factor
Publication Year: 2001 Source: Lab Invest PMID: 11310823 DOI: 10.1038/labinvest.3780238
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H-2 allele specificity of the NK cell C-type lectin-like MHC class I receptor Ly49A visualized by soluble Ly49A tetramer
Publication Year: 2001 Source: Int Immunol PMID: 11312249 DOI: 10.1093/intimm/13.5.615
BACKGROUND AND AIMS: Bacterial proteoglycan-derived muramyl dipeptide (MDP) activates the intracellular NOD2/CARD15 gene product. How intestinal epithelial cells take up MDP is poorly understood. We hypothesized that the intestinal apical di-/tripeptide transporter, hPepT1, transports MDP, thereby activating downstream pathways similar to nuclear factor kappa B (NF-kappaB). METHODS: Time- and concentration-dependent …
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