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Degranulation patterns of eosinophil granulocytes as determinants of eosinophil driven disease
Publication Year: 2001 Source: Thorax PMID: 11312400 DOI: 10.1136/thorax.56.5.341
Multipoint linkage analysis is a powerful tool to localize susceptibility genes for complex diseases. However, the conventional lod score method relies critically on the correct specification of mode of inheritance for accurate estimation of gene position. On the other hand, allele-sharing methods, as currently practiced, are designed to test the …
Family history as a risk factor for colorectal cancer in inflammatory bowel disease
Publication Year: 2001 Source: Gastroenterology PMID: 11313305 DOI: 10.1053/gast.2001.24052
Comment in Am J Gastroenterol. 2000 Aug;95(8):1859-61. OBJECTIVE: The aim of this study was to determine whether a relationship exists between the use of nonsteroidal antiinflammatory drugs (NSAIDs) and exacerbation or onset of inflammatory bowel disease (IBD). METHODS: Sixty consecutive IBD patients admitted to the hospital were carefully interviewed to …
Occupational mortality from inflammatory bowel disease in the United States 1991-1996
Publication Year: 2001 Source: Am J Gastroenterol PMID: 11316154 DOI: 10.1111/j.1572-0241.2001.03747.x
The mucosal immune system may play a critical role in the pathogenesis of small intestinal enteropathies. The aim of the current study was to assess mucosal immune cell populations in dogs with inflammatory bowel disease (IBD), idiopathic antibiotic-responsive diarrhea (ARD), and adverse reactions to food (FR). Endoscopic biopsies were performed …
The prevalence of extraintestinal diseases in inflammatory bowel disease: a population-based study
Publication Year: 2001 Source: Am J Gastroenterol PMID: 11316157 DOI: 10.1111/j.1572-0241.2001.03756.x
BACKGROUND: Hypovitaminosis and fat-soluble vitamin deficiency have been reported in adults with inflammatory bowel disease (IBD). A prospective study was undertaken to determine the prevalence of low serum levels of vitamins A and E in children and young adults with IBD. METHODS: Clinical information and serum for vitamin levels was …
Association of susceptibility locus for inflammatory bowel disease on chromosome 16 with both ulcerative colitis and Crohn's disease
Publication Year: 2001 Source: Dig Dis Sci PMID: 11318544 DOI: 10.1023/a:1005623904826
BACKGROUND: The association between the human cytotoxic T lymphocyte-associated antigen-4 (CTLA4) gene and insulin-dependent diabetes mellitus (IDDM) is unclear in populations. We therefore investigated whether the gene conferred susceptibility to IDDM in a Russian population. We studied two polymorphic regions of the CTLA4 gene, the codon 17 dimorphism and the …
Reduced free protein S levels in patients with inflammatory bowel disease: prevalence, clinical relevance, and role of anti-protein S antibodies
Publication Year: 2001 Source: Dig Dis Sci PMID: 11318545 DOI: 10.1023/a:1005675921664
The risk of lymphoproliferative disorders (LPDs) has been reported to be increased in autoimmune diseases and chronic inflammatory diseases. Similar with other chronic inflammatory diseases such as rheumatoid arthritis, there is a concern about the risk of LPDs in patients with inflammatory bowel disease (IBD). Generally, in IBD patients, the …
Power and robustness of a score test for linkage analysis of quantitative traits using identity by descent data on sib pairs
Publication Year: 2001 Source: Genet Epidemiol PMID: 11319783 DOI: 10.1002/gepi.1011
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Fecal calprotectin as a measure of disease activity in childhood inflammatory bowel disease
Publication Year: 2001 Source: J Pediatr Gastroenterol Nutr PMID: 11321388 DOI: 10.1097/00005176-200102000-00015
Cytokine-mediated impairment of viability and metabolic function of epithelial cells has been suggested as a possible early pathogenic event in the development of inflammatory bowel disease (IBD). It is currently unknown whether pro-inflammatory cytokines have a direct effect on human nontransformed colonic epithelial cells. We investigated the effects of TNFalpha, …
In vitro effects of naloxone on T-lymphocyte-dependent antibacterial activity in hepatitis C virus (HCV) infected patients and in inflammatory bowel disease (IBD) patients
Publication Year: 2001 Source: Immunopharmacol Immunotoxicol PMID: 11322642 DOI: 10.1081/iph-100102562
BACKGROUND AND AIMS: Inflammatory bowel disease (IBD) is frequently complicated by extracellular matrix (ECM) changes that may result in fibrosis. Transforming growth factor (TGF)-beta1 and insulin-like growth factor (IGF)-1 mediate numerous ECM changes. Our aim was to determine whether TGF-beta1 and IGF-1 are involved in intestinal ECM collagen regulation and …
Does better disease-related education improve quality of life? A survey of IBD patients
Publication Year: 2001 Source: Dig Dis Sci PMID: 11330426 DOI: 10.1023/a:1010725106411
OBJECTIVE: To determine the effect of a specialist nurse on the management outcome of patients with inflammatory bowel disease (IBD). DESIGN: Audit of the management of a cohort of patients in the year prior to the employment of the specialist nurse and the year immediately after. SUBJECTS: 339 patients, both …
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