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Multipoint development of the weighted pairwise correlation (WPC) linkage method for pedigrees of arbitrary size and application to the analysis of breast cancer and alcoholism familial data
Publication Year: 2001 Source: Genet Epidemiol PMID: 11443733 DOI: 10.1002/gepi.1017
The pathogenesis of ulcerative colitis (UC) and Crohn's disease (CD) is still unknown, but the importance of genetic susceptibility has been clearly shown by epidemiological data from family and twin studies. Linkage studies have identified two susceptibility loci for inflammatory bowel disease (IBD) on chromosomes 12 and 16. Importantly, these …
A genomewide linkage study of age at onset in schizophrenia
Publication Year: 2001 Source: Am J Med Genet PMID: 11449396 DOI: 10.1002/ajmg.1404
BACKGROUND: Clinical response to thiopurine medication is related to the concentration of its metabolites. Proxy measures are traditionally used to assess dose adequacy. We present our experience of using tioguanine (previously known/formerly referred to as thioguanine) metabolite measurements in paediatric patients and evaluate their effect on clinical practice. AIMS: To …
On relationship inference using gamete identity by descent data
Publication Year: 2001 Source: J Comput Biol PMID: 11454305 DOI: 10.1089/106652701300312940
BACKGROUND & AIMS: Coping strategies are used to manage conflict and illness and can have adaptive or maladaptive effects on health status. Perceived availability and quality of social support also influences health status. Coping strategies and social support have not been well studied in irritable bowel syndrome (IBS) or inflammatory …
Loss of transforming growth factor beta signalling in the intestine contributes to tissue injury in inflammatory bowel disease
Publication Year: 2001 Source: Gut PMID: 11454793 DOI: 10.1136/gut.49.2.190
BACKGROUND: Calprotectin is an abundant neutrophil protein that is extremely stable in feces. The aim of this study was to assess the effectiveness of fecal calprotectin as a noninvasive measure of disease activity in childhood inflammatory bowel disease (IBD) by comparison to a modified Lloyd-Still and Green score and laboratory …
Inflammatory bowel disease and laterality: is left handedness a risk?
Publication Year: 2001 Source: Gut PMID: 11454794 DOI: 10.1136/gut.49.2.199
OBJECTIVE: The purpose of this study was to investigate the presence of emotional abuse and two psychosocial constructs (self-blame and self-silencing) in a sample of women diagnosed with irritable bowel syndrome (IBS) relative to a comparison sample of women diagnosed with inflammatory bowel disease (IBD). METHODS: Women diagnosed with IBS …
Association of the tumour necrosis factor alpha -308 but not the interleukin 10 -627 promoter polymorphism with genetic susceptibility to primary sclerosing cholangitis
Publication Year: 2001 Source: Gut PMID: 11454808 DOI: 10.1136/gut.49.2.288
Crohn's disease and ulcerative colitis are chronic inflammatory bowel diseases (IBD) of unknown etiology but demonstrate a rising incidence in many western countries. Although little is known about inflammatory pathomechanisms which are specific to either Crohn's disease or ulcerative colitis, a distinction between both diseases can often be made by …
Efficacy of use of colonoscopy in dextran sulfate sodium induced ulcerative colitis in rats: the evaluation of the effects of antioxidant by colonoscopy
Publication Year: 2001 Source: Int J Colorectal Dis PMID: 11459291 DOI: 10.1007/s003840000282
Comment in Am J Gastroenterol. 2000 Sep;95(9):2395. Am J Gastroenterol. 2000 Oct;95(10):3013-4. OBJECTIVE: Patients with inflammatory bowel disease (IBD) frequently suffer from thromboembolic events. A recently identified mechanism for thrombophilia, the poor anticoagulant response to activated protein C, has been suggested as one of the leading risk factors for thrombosis. …
Characterization of chemokines and chemokine receptors in two murine models of inflammatory bowel disease: IL-10-/- mice and Rag-2-/- mice reconstituted with CD4+CD45RBhigh T cells
Publication Year: 2001 Source: Eur J Immunol PMID: 11465103 DOI: 10.1002/1521-4141(200105)31:5<1465::AID-IMMU1465>3.0.CO;2-E
The present study was undertaken to investigate the intestinal anti-inflammatory effects of UR-12746 on the acute and chronic stages of a trinitrobenzene sulphonic acid (TNBS) experimental model of inflammatory bowel disease (IBD) in the rat. UR-12746 is a novel, locally-acting compound which combines, through an azo bond, 5-aminosalicylic (5-ASA) and …
The comorbid occurrence of other diagnoses in patients with ulcerative colitis and Crohn's disease
Publication Year: 2001 Source: Am J Gastroenterol PMID: 11467640 DOI: 10.1111/j.1572-0241.2001.03943.x
BACKGROUND: The potential role of superantigens in inflammatory bowel disease (IBD), particularly Crohn disease, has been broached in studies of the functions of T cell receptors. Staphylococcal cells have been found in intestinal lymph follicles of IBDs. To clarify a role of staphylococcal superantigens in IBD, we attempted to determine …
The relationship between inflammatory bowel disease and socioeconomic variables
Publication Year: 2001 Source: Am J Gastroenterol PMID: 11467642 DOI: 10.1111/j.1572-0241.2001.03946.x
BACKGROUND: An association between primary sclerosing cholangitis (PSC) and inflammatory bowel disease (IBD) is well recognized. However, the disease course of IBD following liver transplantation (LT) for PSC remains ill-defined. AIMS AND METHODS: We aimed to assess the impact of IBD in patients that had undergone LT for PSC to …
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