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The score statistic of the LD-lod analysis: detecting linkage adaptive to linkage disequilibrium
Publication Year: 2001 Source: Hum Hered PMID: 11474209 DOI: 10.1159/000053359
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Role of polymorphisms in the interleukin-10 gene in determining disease susceptibility and phenotype in inflamatory bowel disease
Publication Year: 2001 Source: Dig Dis Sci PMID: 11478505 DOI: 10.1023/a:1010604307776
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Fecal calprotectin: validation as a noninvasive measure of bowel inflammation in childhood inflammatory bowel disease
Publication Year: 2001 Source: J Pediatr Gastroenterol Nutr PMID: 11479402 DOI: 10.1097/00005176-200107000-00003
Comment in Hepatology. 2000 Jan;31(1):247-8. Patients with primary sclerosing cholangitis (PSC) have a significantly increased risk of developing cholangiocarcinoma (CCA). Risk factors for developing such a complication are not well defined. We conducted a multicenter, case-control study to determine the risk factors and possible predictors for CCA in patients with …
IBD sharing around the PPARG locus is not increased in dizygotic twins or their mothers
Publication Year: 2001 Source: Nat Genet PMID: 11479591 DOI: 10.1038/91074
Recent studies strongly support the concept that gut and joint inflammation are closely related. Progress also has been made in identifying individual mechanisms that contribute to the pathogenesis of joint disease in IBD and in undifferentiated SpAs. However, the interrelationship of these mechanisms that result in chronic disease manifestations at …
TNF-alpha induced endothelial MAdCAM-1 expression is regulated by exogenous, not endogenous nitric oxide
Publication Year: 2001 Source: BMC Gastroenterol PMID: 11481030 DOI: 10.1186/1471-230x-1-5
BACKGROUND AND AIMS: Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease of unknown aetiology. Abnormalities in immune regulation and genetic associations suggest that PSC is an immune mediated disease. Several polymorphisms within the tumour necrosis factor alpha (TNF-alpha) and interleukin 10 (IL-10) promoter genes have been described which …
Soluble adhesion molecules in inflammatory bowel disease
Publication Year: 2001 Source: Ir J Med Sci PMID: 11491044 DOI: 10.1007/BF03168821
OBJECTIVE: The aim of this work was to study cross-cultural variations in the impact of inflammatory bowel disease (IBD) on health-related quality of life by an international comparison of disease-related concerns. METHODS: Item and factor scores on the Rating Form of Inflammatory Bowel Disease Patient Concerns and overall mean concern …
Animal models for primary sclerosing cholangitis
Publication Year: 2001 Source: Best Pract Res Clin Gastroenterol PMID: 11492970 DOI: 10.1053/bega.2001.0207
The ENS is responsible for the regulation and control of all gastrointestinal functions. Because of this critical role, and probably as a consequence of its remarkable plasticity, the ENS is often relatively well preserved in conditions where the architecture of the intestine is seriously disrupted, such as in IBD. There …
Liver transplantation for primary sclerosing cholangitis: timing, outcome, impact of inflammatory bowel disease and recurrence of disease
Publication Year: 2001 Source: Best Pract Res Clin Gastroenterol PMID: 11492975 DOI: 10.1053/bega.2001.0212
A susceptibility locus for inflammatory bowel disease (IBD) on chromosome 16 (IBD1) has been linked to Crohn's disease in genome-wide linkage studies. We performed a case-control study with two markers for this locus using leukocyte DNA from 127 Crohn's patients, 83 ulcerative colitis patients, and 74 control patients. Allele, genotype, …
Meta-analysis for model-free methods
Publication Year: 2001 Source: Adv Genet PMID: 11037326 DOI: 10.1016/s0065-2660(01)42027-x
In patients with inflammatory bowel disease (IBD), including ulcerative colitis (UC), heat-shock protein (Hsp) 60 has been detected in serum and the intestinal tract. Our mouse colitis model was established using Escherichia coli transformed with Yersinia enterocolitica Hsp60 gene as an immunizing antigen, and examined light and electron microscopically as …
The role of interacting determinants in the localization of genes
Publication Year: 2001 Source: Adv Genet PMID: 11037332 DOI: 10.1016/s0065-2660(01)42033-5
Structural proteins of the poultry pathogen, infectious bursal disease virus (IBDV), were expressed in the baculovirus/insect cell expression system. To date, several reports have indicated that animal virus structural proteins are expressed only at low yield in this system. In this article, several factors were examined to enhance yield. These …
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