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A robust identity-by-descent procedure using affected sib pairs: multipoint mapping for complex diseases

Publication Year: 2001 Source: Hum Hered PMID: 11096273 DOI: 10.1159/000022961

BACKGROUND: Studies have suggested that scans with technetium-tagged white blood cells (WBC-Tc99m) may be equal to endoscopy in the assessment of extent and activity of inflammatory bowel disease (IBD). OBJECTIVE: We have retrospectively examined the accuracy of WBC-Tc99m scans in differentiating continuous from discontinuous colitis in pediatric IBD. MATERIALS AND …

Intestinal permeability in Behçet's syndrome

Publication Year: 2001 Source: Ann Rheum Dis PMID: 11114285 DOI: 10.1136/ard.60.1.65

BACKGROUND/AIMS: We investigated the mRNA expression of spectrum of cytokines in the colonic mucosa in inflammatory bowel disease (IBD). METHODS: The expression of cytokine gene was evaluated by using the reverse transcription-polymerase chain reaction and the radioactivity of amplified cDNA standardized by coamplified beta-actin cDNA. RESULTS: Crohn's disease and ulcerative …

Consequences of intestinal inflammation on the enteric nervous system: neuronal activation induced by inflammatory mediators

Publication Year: 2001 Source: Anat Rec PMID: 11146431 DOI: 10.1002/1097-0185(20010101)262:1<79::AID-AR1013>3.0.CO;2-K

Not found

Induction of inflammatory bowel disease in immunodeficient mice by depletion of regulatory T cells

Publication Year: 2001 Source: Curr Protoc Immunol PMID: 18432730 DOI: 10.1002/0471142735.im1513s30

In this paper, we present a unified mathematical model for linkage analysis that allows for inbreeding among founders in all families. The identical by descent (IBD) configuration of each pedigree is modeled as a Markov process containing two parameters; the inverse inbreeding and kinship coefficient and a rate parameter proportional …

Gene transfer into the colonic mucosa

Publication Year: 2001 Source: Methods Mol Med PMID: 21318836 DOI: 10.1385/1-59259-084-5:275

We compared the robustness of affected-sib-pair (ASP) tests for multiple-affected sibships. Forming all possible pairs increases the type I errors only slightly whereas the most used weighting procedures decrease the efficiency of the tests. Another weighting procedure accounting for the reduction of variance of the weighted identical by descent (IBD) …

Efficacy of inactivated infectious bursal disease (IBD) vaccines: comparison of serology with protection of progeny chickens against IBD virus strains of varying virulence

Publication Year: 2001 Source: Avian Pathol PMID: 19184920 DOI: 10.1080/03079450120066359

The use of complementary and alternative medicine (CAM) by patients with inflammatory bowel disease (IBD) is common. Physicians and scientists believe that the randomized controlled trial (RCT) provides the best evidence of an intervention's efficacy. However, there are only a few controlled trials that have assessed these therapies in IBD …

Acute infectious bursal disease in poultry: a review

Publication Year: 2000 Source: Avian Pathol PMID: 19184804 DOI: 10.1080/03079450050045431

Not found

Replication of classical infectious bursal disease virus in the chicken embryo related cell line

Publication Year: 2000 Source: Avian Pathol PMID: 19184807 DOI: 10.1080/03079450050045468

Thromboembolism has been shown to play a role in the pathogenesis of inflammatory bowel disease (IBD). A possibility exists that lipoprotein (a) [Lp(a)], a newly-discovered prothrombotic factor, also participates in the development of at least some cases of IBD. Marked elevation of serum Lp(a) levels was observed in a young …

Computation of identity by descent probabilities conditional on DNA markers via a Monte Carlo Markov Chain method

Publication Year: 2000 Source: Genet Sel Evol PMID: 14736376 DOI: 10.1186/1297-9686-32-5-467

We report a case of simultaneous occurrence of inflammatory bowel disease (IBD) and Graves' disease. A review of reported cases of simultaneous onset of ulcerative colitis (UC) and autoimmune hyperthyroidism is presented. A discussion of the prevalence of thyroid disease in patients with UC and possible common autoimmune etiology is …

A score test for the linkage analysis of qualitative and quantitative traits based on identity by descent data from sib-pairs

Publication Year: 2000 Source: Biostatistics PMID: 12933522 DOI: 10.1093/biostatistics/1.1.1

A novel and robust method for the fine-scale mapping of genes affecting complex traits, which combines linkage and linkage-disequilibrium information, is proposed. Linkage information refers to recombinations within the marker-genotyped generations and linkage disequilibrium to historical recombinations before genotyping started. The identity-by-descent (IBD) probabilities at the quantitative trait locus (QTL) …

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