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Does clinical exposure affect medical student examination performance?
Publication Year: 2000 Source: Am J Surg PMID: 10875986 DOI: 10.1016/s0002-9610(00)00338-x
The objective of this study was to use a robust variance component method to analyse unipolar and bipolar disorder in a large Scottish extended family (n = 168) in which linkage between markers and disease has been previously reported on the short arm of chromosome 4. Data consisted of diagnosed …
Relation between colonic inflammation severity and total low-molecular-weight antioxidant profiles in experimental colitis
Publication Year: 2000 Source: Dig Dis Sci PMID: 10877235 DOI: 10.1023/a:1005510321278
BACKGROUND: Intestinal barrier dysfunction concomitant with high levels of reactive oxygen metabolites (ROM) in the inflamed mucosa have been observed in inflammatory bowel disease (IBD). The cytoskeletal network has been suggested to be involved in the regulation of barrier function. Growth factors (epidermal growth factor (EGF) and transforming growth factor …
Comprehensive nutritional status in recently diagnosed patients with inflammatory bowel disease compared with population controls
Publication Year: 2000 Source: Eur J Clin Nutr PMID: 10878655 DOI: 10.1038/sj.ejcn.1601049
BACKGROUND & AIMS: Alterations in intestinal epithelial cell function are common in inflammatory bowel disease (IBD). Keratinocyte growth factor (KGF) is an epithelial cell-specific mitogen. The aim of this study was to examine IBD tissue for altered KGF expression. METHODS: Expression levels of the KGF and KGF receptor transcripts were …
An analysis of an inflammatory bowel disease practice in an urban community hospital
Publication Year: 2000 Source: Can J Gastroenterol PMID: 10888727 DOI: 10.1155/2000/819418
Comment in Eur J Gastroenterol Hepatol. 1999 Sep;11(9):997-9. BACKGROUND: Rheumatological and other extraintestinal manifestations (EIM) are common in inflammatory bowel disease (IBD) but also seem to occur in patients after restorative proctocolectomy and formation of an ileo-anal pouch. The prevalence and significance of these symptoms have not been established in …
Surrogate markers of intestinal inflammation are predictive of relapse in patients with inflammatory bowel disease
Publication Year: 2000 Source: Gastroenterology PMID: 10889150 DOI: 10.1053/gast.2000.8523
In the face of a hardly predictable course of illness--potentially effecting a severe diminution of daily activities--the quality of life (QOL) represents a chief outcome measure in the treatment of inflammatory bowel diseases (IBD). For the German-speaking area an economical disease-specific instrument measuring QOL has been missing, so far. Therefore, …
Three-dimensional (87)Rb NMR imaging and spectroscopy of K(+) fluxes in normal and postischemic pig hearts
Publication Year: 2000 Source: Magn Reson Med PMID: 10893525 DOI: 10.1002/1522-2594(200007)44:1<83::aid-mrm13>3.0.co;2-r
A new class of outer membrane lipid (OML) was isolated from the oral spirochete Treponema denticola strain ATCC 33521 using a phenol/chloroform/light petroleum procedure normally applied for lipopolysaccharide extraction. In addition to chemical analysis, Fourier transform infrared (FTIR) spectroscopy was applied to compare the biophysical properties of OML with lipopolysaccharides …
Early measles virus infection is associated with the development of inflammatory bowel disease
Publication Year: 2000 Source: Am J Gastroenterol PMID: 10894583 DOI: 10.1111/j.1572-0241.2000.02082.x
Erratum in Am J Hum Genet 2000 Jun;66(6):2020. Extreme discordant sibling-pair (EDSP) designs have been shown in theory to be very powerful for mapping quantitative-trait loci (QTLs) in humans. However, their practical applicability has been somewhat limited by the need to phenotype very large populations to find enough pairs that …
Phagocytosis, killing, lymphocyte-mediated antibacterial activity, serum autoantibodies, and plasma endotoxins in inflammatory bowel disease
Publication Year: 2000 Source: Am J Gastroenterol PMID: 10894586 DOI: 10.1111/j.1572-0241.2000.02085.x
The pathogenesis of ulcerative colitis (UC) and Crohn's disease (CD) may be associated with a decreased production of cytokines suppressing macrophage and T-cell functions: interleukins (IL) -4 and IL-10. Serum concentrations of IL-4 and IL-10 were measured using an ELISA technique, and intestinal IL-4 and IL-10 mRNA was detected by …
An increased number of CD40-high monocytes in patients with Crohn's disease
Publication Year: 2000 Source: Am J Gastroenterol PMID: 10894589 DOI: 10.1111/j.1572-0241.2000.01938.x
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Cd1d-restricted cellular lysis by peripheral blood lymphocytes: relevance to the inflammatory bowel diseases
Publication Year: 2000 Source: J Surg Res PMID: 10896824 DOI: 10.1006/jsre.2000.5940
BACKGROUND: Keratinocyte growth factor (KGF) stimulates gastrointestinal epithelial cells in vivo, and is protective against gastrointestinal injury and colitis. Endogenous KGF is increased in inflammatory bowel disease (IBD), and may be an important mediator of mucosal repair. KGF is expressed by mesenchymal cells and activated intraepithelial lymphocytes (IEL). AIMS: To …
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