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Lessons from genetically engineered animal models. XII. IL-10-deficient (IL-10(-/-) mice and intestinal inflammation
Publication Year: 2000 Source: Am J Physiol Gastrointest Liver Physiol PMID: 10859210 DOI: 10.1152/ajpgi.2000.278.6.G829
: Growth retardation is common in children with inflammatory bowel disease (IBD). The most sensitive measure of impaired growth, growth velocity, is abnormal in 65% of children with Crohn's disease. With treatment, growth velocity may return to normal, but catch-up growth is often incomplete and ultimate height lower than predicted. …
Imbalance of stromelysin-1 and TIMP-1 in the mucosal lesions of children with inflammatory bowel disease
Publication Year: 2000 Source: Gut PMID: 10861265 DOI: 10.1136/gut.47.1.57
BACKGROUND AND AIMS: Macrophages play an important role during mucosal inflammation in inflammatory bowel disease (IBD). As the co-stimulatory molecules B7-1 (CD80) and B7-2 (CD86) play an integral role in the activation of T cells by antigen-presenting cells (APC) we investigated the surface expression of B7-1 and B7-2 on colonic …
Differential expression of matrix metalloproteinases and their tissue inhibitors in colon mucosa of patients with inflammatory bowel disease
Publication Year: 2000 Source: Gut PMID: 10861266 DOI: 10.1136/gut.47.1.63
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Annual cancer incidence rates for Hispanics in the United States: surveillance, epidemiology, and end results, 1992-1996
Publication Year: 2000 Source: Cancer PMID: 10861444 DOI: 10.1002/1097-0142(20000601)88:11<2642::aid-cncr29>3.0.co;2-s
Expression of the COX-2 enzyme has been reported in animal models of inflammatory bowel disease (IBD) as well as in patients affected by ulcerative colitis and Crohn's disease. Recently, selective inhibitors of COX-2 have become available. In this study we have evaluated three highly selective COX-2 inhibitors, NS-398, SC-58125 and …
Endothelial cell autoantibodies are a marker of disease susceptibility in inflammatory bowel disease but apparently not linked to persistent measles virus infection
Publication Year: 2000 Source: Clin Immunol PMID: 10866126 DOI: 10.1006/clim.2000.4867
Inflammatory bowel diseases (IBD) are complex disorders. While the exact etiology of these diseases remains unknown, recent progress in the epidemiology and genetics of IBD has clearly demonstrated both environmental and genetic factors to play a role in the development of the disease, and it is expected that some risk …
Therapy of inflammatory bowel disease
Publication Year: 2000 Source: Gastroenterology PMID: 10868899 DOI: 10.1016/s0016-5085(00)70007-2
Patients with inflammatory bowel disease (IBD) are at increased risk for developing cancer of the gastrointestinal tract, particularly colorectal cancer. Because of the relative rarity of IBD in the general population, it has been difficult to quantify this risk. Efforts to reduce the risk have included both prophylactic surgery and …
Microsatellite instability and K-ras mutations in patients with ulcerative colitis
Publication Year: 2000 Source: Hum Pathol PMID: 10872658 DOI: 10.1053/hupa.2000.7643
OBJECTIVES: To date, few studies have evaluated gastric histology in patients with inflammatory bowel disease (IBD). The aim of this prospective controlled study was to establish the frequency of focal gastritis in Crohn's disease (CD) and ulcerative colitis (UC) patients, as well as to evaluate its immunohistochemical characteristics and clinicoanatomical …
Treatment of inflammatory bowel disease in a rodent model with the intestinal growth factor glucagon-like peptide-2
Publication Year: 2000 Source: J Pediatr Surg PMID: 10873024 DOI: 10.1053/jpsu.2000.6861
BACKGROUND & AIMS: The multidrug resistance (MDR) gene codes for a drug efflux pump P-glycoprotein 170 (Pgp-170) expressed on the surface of lymphocytes and intestinal epithelial cells. Inflammatory bowel disease (IBD) poorly responsive to medical therapy may relate to MDR expression because glucocorticoids are known Pgp-170 substrates. METHODS: Using flow …
Raised human cartilage glycoprotein-39 plasma levels in patients with rheumatoid arthritis and other inflammatory conditions
Publication Year: 2000 Source: Ann Rheum Dis PMID: 10873965 DOI: 10.1136/ard.59.7.544
The risk of colorectal carcinoma is increased in pediatric-onset inflammatory bowel disease (IBD). There is little information available regarding the colonic mucosal proliferative state in children with IBD. The aim of this study was to assess colonic ornithine decarboxylase (ODC) activity, a marker of cell proliferation, in pediatric IBD patients. …
Normal thiopurine methyltransferase levels do not eliminate 6-mercaptopurine or azathioprine toxicity in children with inflammatory bowel disease
Publication Year: 2000 Source: J Clin Gastroenterol PMID: 10875470 DOI: 10.1097/00004836-200006000-00011
BACKGROUND: Calprotectin is released from neutrophils and monocytes, and increased calprotectin levels in stool may serve as a marker of intestinal inflammation. Intestinal permeability is increased in inflammatory bowel diseases, especially in Crohn disease. We studied the relationship between intestinal permeability and calprotectin concentration in intestinal lavage fluid in patients …
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