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"Atypical p-ANCA" in IBD and hepatobiliary disorders react with a 50-kilodalton nuclear envelope protein of neutrophils and myeloid cell lines
Publication Year: 2000 Source: Gastroenterology PMID: 10930366 DOI: 10.1053/gast.2000.9366
The idiopathic inflammatory bowel diseases (IBDs), consisting of Crohn's disease and ulcerative colitis, are complex genetic disorders involving chronic inflammation of the intestines. Multiple genetic loci have been implicated through genome-wide searches, but refinement of localization sufficient to undertake positional cloning efforts has been problematic. This difficulty can be obviated …
Neutropenia, neutrophil dysfunction, and inflammatory bowel disease in glycogen storage disease type Ib: results of the European Study on Glycogen Storage Disease type I
Publication Year: 2000 Source: J Pediatr PMID: 10931410 DOI: 10.1067/mpd.2000.105232
Comment on Proc Natl Acad Sci U S A. 2011 Mar 15;108 Suppl 1:4623-30. Although much has become known about the pathogenesis of inflammatory bowel disease (IBD), our understanding remains incomplete. As a consequence, IBD conditions are chronic debilitating states without cure. A recent study elegantly describes a mechanism by …
Prevalence of factor V Leiden and the G20210A prothrombin-gene mutation in inflammatory bowel disease
Publication Year: 2000 Source: Blood Coagul Fibrinolysis PMID: 10937811 DOI: 10.1097/00001721-200007000-00013
BACKGROUND: Transforming growth factors (TGF-alpha and -beta1) play important roles in intestinal growth and repair. To further understand their roles in the pathophysiology of inflammatory bowel disease (IBD), this study examined changes in their expression in colonic mucosa of adolescents with IBD. METHODS: TGF-alpha and -beta1 expression was examined by …
Neurokinin-1 receptor expression in inflammatory bowel disease: molecular quantitation and localisation
Publication Year: 2000 Source: Gut PMID: 10940277 DOI: 10.1136/gut.47.3.387
BACKGROUND: Children with inflammatory bowel disease (IBD) undergo imaging using ionizing radiation and may be exposed to high cumulative radiation. We hypothesized that children with IBD have high exposure to radiation from medical imaging. METHODS: An Institutional Review Board (IRB)-approved retrospective chart review from 2002-2008 was performed on all patients …
Efficacy of ursodeoxycholic acid in the treatment of primary sclerosing cholangitis in children
Publication Year: 2000 Source: J Pediatr Gastroenterol Nutr PMID: 10941964 DOI: 10.1097/00005176-200008000-00009
BACKGROUND: The expansion of the Surveillance, Epidemiology, and End Results (SEER) program and the determination of annual population estimates by county level for different racial/ethnic groups since 1990 allow the calculation of annual cancer incidence rates for Hispanics. METHODS: Incidence rates were calculated for 11 SEER areas representing 25% of …
Concurrence of inflammatory bowel disease and multiple sclerosis
Publication Year: 2000 Source: Mayo Clin Proc PMID: 10943233 DOI: 10.4065/75.8.802
OBJECTIVE: Increased nitric oxide (NO) has been demonstrated in inflammatory bowel diseases (IBD). Plasma and urinary nitrite and nitrate are usually considered to reflect global NO generation. Recently it has been suggested that plasma nitrate may be a discriminant indicator between infectious enterocolitis (IC) and IBD. To investigate this hypothesis …
Multipoint linkage analysis of a candidate gene locus in rheumatoid arthritis demonstrates significant evidence of linkage and association with the corticotropin-releasing hormone genomic region
Publication Year: 2000 Source: Arthritis Rheum PMID: 10943856 DOI: 10.1002/1529-0131(200008)43:8<1673::AID-ANR2>3.0.CO;2-Y
Because reactive oxygen species (ROS) have been implicated as mediators of inflammatory bowel disease (IBD), the purpose of the present work was to determine the functional role of mucosal GSH in the trinitrobenzenesulfonic acid in 50% ethanol (TNBS+ethanol)-induced colitis in rats. Mucosal samples were taken to evaluate the temporal relationship …
Tolerance of nonsteroidal antiinflammatory drugs in patients with inflammatory bowel disease
Publication Year: 2000 Source: Am J Gastroenterol PMID: 10950040 DOI: 10.1111/j.1572-0241.2000.02263.x
OBJECTIVE: The goal of this retrospective study was to assess whether 99mTc-white blood cell (WBC) scintigraphy and upper gastrointestinal small bowel follow-through (UGI-SBFT) could exclude inflammation in children suspected of having inflammatory bowel disease (IBD). METHODS: Of a population of 313 children who had a 99mTc-WBC scan, 130 children were …
Effects of nonsteroidal antiinflammatory drugs on inflammatory bowel disease: a case-control study
Publication Year: 2000 Source: Am J Gastroenterol PMID: 10950041 DOI: 10.1111/j.1572-0241.2000.02262.x
Sib pair-selection strategies, designed to identify the most informative sib pairs in order to detect a quantitative-trait locus (QTL), give rise to a missing-data problem in genetic covariance-structure modeling of QTL effects. After selection, phenotypic data are available for all sibs, but marker data-and, consequently, the identity-by-descent (IBD) probabilities-are available …
Colonic inflammation found at diagnosis of juvenile retention polyps in pediatric patients
Publication Year: 2000 Source: Am J Gastroenterol PMID: 10950047 DOI: 10.1111/j.1572-0241.2000.02253.x
OBJECTIVE: We sought to examine whether use of nonsteroidal antiinflammatory drugs (NSAIDs) in an outpatient inflammatory bowel disease (IBD) population is associated with an increased likelihood of active disease. METHODS: We reviewed records of initial outpatient visits of IBD patients to the principal author from June 1995 to December 1997, …
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