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Higher expression of glucocorticoid receptor in peripheral mononuclear cells in inflammatory bowel disease
Publication Year: 2000 Source: Am J Gastroenterol PMID: 10950048 DOI: 10.1111/j.1572-0241.2000.02188.x
BACKGROUND: Several studies suggest an increased risk of venous and arterial thromboembolism (TE) in adults with inflammatory bowel disease (IBD) compared to the general population. We performed a systematic review of studies on incidence and characteristic of TE in children with IBD. METHODS: We searched Medline, LILACS, EMBASE, POPLINE, CINHAL, …
Detection of autoantibodies against tissue transglutaminase in patients with celiac disease and dermatitis herpetiformis
Publication Year: 2000 Source: Am J Gastroenterol PMID: 10950050 DOI: 10.1111/j.1572-0241.2000.02086.x
Comment in Eur J Gastroenterol Hepatol. 2000 Jan;12(1):3-4. OBJECTIVE: Educating patients with irritable bowel syndrome (IBS) about their disorder may promote a strong physician-patient interaction, is a recommended approach for treating mild IBS and may reduce healthcare use. Our aim was to identify the information needs, levels and associated factors …
Recombinant human interleukin-11 modulates ion transport and mucosal inflammation in the small intestine and colon
Publication Year: 2000 Source: Lab Invest PMID: 10950118 DOI: 10.1038/labinvest.3780135
BACKGROUND: Patients with inflammatory bowel disease (IBD) are at risk of developing metabolic bone disease. In diagnosing osteoporosis, bone mineral density (BMD) measurements play a key role. Our aims in this study were to assess the skeletal status with quantitative ultrasound (QUS) and to evaluate the ability of this method …
The pancreas and inflammatory bowel diseases
Publication Year: 2000 Source: Int J Pancreatol PMID: 10952399 DOI: 10.1385/IJGC:27:3:171
The last decade has seen tremendous advances in our knowledge, which has led to genuine improvements in our understanding of the pathogenesis and management of inflammatory bowel disease (IBD). The combined power of cellular and molecular biology has begun to unveil the enigmas of IBD, and, consequently, substantial gains have …
Intestinal anti-inflammatory activity of UR-12746, a novel 5-ASA conjugate, on acute and chronic experimental colitis in the rat
Publication Year: 2000 Source: Br J Pharmacol PMID: 10952687 DOI: 10.1038/sj.bjp.0703505
The two primary human inflammatory bowel diseases, Crohn's disease (CD) and ulcerative colitis (UC), are idiopathic relapsing disorders characterized by chronic inflammation of the intestinal tract. Although several lines of reasoning suggest that gastrointestinal (GI) microbes influence inflammatory bowel disease (IBD) pathogenesis, the types of microbes involved have not been …
Animal models of intestinal inflammation: new insights into the molecular pathogenesis and immunotherapy of inflammatory bowel disease
Publication Year: 2000 Source: Int J Colorectal Dis PMID: 10954186 DOI: 10.1007/s003840000227
BACKGROUND & AIMS: Inflammatory bowel disease (IBD) is a multifactorial disease thought to be caused by alterations in epithelial function, innate and adaptive immunity, and luminal microbiota. The specific role of epithelial barrier function remains undefined, although increased activity of intestinal epithelial myosin light chain kinase (MLCK), which is the …
Transfer of interleukin-4 and interleukin-10 in patients with severe inflammatory bowel disease of the rectum
Publication Year: 2000 Source: Hum Gene Ther PMID: 10954907 DOI: 10.1089/10430340050111386
Previous studies support a role for intestinal epithelial cells (IEC) as antigen-presenting cells in mucosal immune responses. T cells activated by IEC are CD8+, suppressor in function, and dependent upon CD8-associated p56lck activation. A 180-kD glycoprotein (gp180) recognized by mAbs B9 and L12 has been identified and shown to be …
Recent advances in the diagnosis and treatment of pediatric inflammatory bowel disease
Publication Year: 2000 Source: Curr Gastroenterol Rep PMID: 10957937 DOI: 10.1007/s11894-000-0068-y
Although Crohn's disease and ulcerative colitis were initially described in young adults, it has become increasingly apparent that inflammatory bowel disease (IBD) affects the elderly, with the new onset of disease occurring well into the seventh and eighth decades of life. The diagnosis of IBD in the elderly may be …
Smoking and inflammatory bowel disease
Publication Year: 2000 Source: Eur J Gastroenterol Hepatol PMID: 10958212 DOI: 10.1097/00042737-200012080-00004
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Treatment of murine colitis by Lactococcus lactis secreting interleukin-10
Publication Year: 2000 Source: Science PMID: 10958782 DOI: 10.1126/science.289.5483.1352
Patients with primary sclerosing cholangitis (PSC) in Japan have two peaks in age distribution, one in their twenties and the other in their fifties and sixties. PSC patients in Japan have different characteristics from those in other countries: there is a higher incidence of eosinophilia (27%) and positivity for anti-nuclear …
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