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Metabolic bone disease in IBD

Publication Year: 2000 Source: Curr Gastroenterol Rep PMID: 10981030 DOI: 10.1007/s11894-000-0025-9

PURPOSE: Evaluation of hydro-MRI in the diagnosis of chronic inflammatory bowel disease (IBD). MATERIAL AND METHODS: 33 patients with suspected Crohn's disease or ulcerative colitis were studied prospectively. After distension of the colon by a rectal enema, breathhold MR imaging was performed during bowel relaxation. Results were compared to the …

Pediatric inflammatory bowel disease imaged with Tc-99m white blood cells

Publication Year: 2000 Source: Clin Nucl Med PMID: 10983760 DOI: 10.1097/00003072-200009000-00012

Erratum in Inflamm Bowel Dis. 2009 Sep;15(9):1438-47. Research and technological advancements have fostered a novel approach to understanding the intricate relationship between genetic and clinical expression of disease. Both genetic and serum antibody markers hold the most promise in helping researchers better comprehend disease heterogeneity and natural history. Although our …

Specific targeting of IL-6 signalling pathway: a new way to treat IBD?

Publication Year: 2000 Source: Gut PMID: 10986204 DOI: 10.1136/gut.47.4.465

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Increased incidence of non-Hodgkin's lymphoma in inflammatory bowel disease patients on immunosuppressive therapy but overall risk is low

Publication Year: 2000 Source: Gut PMID: 10986211 DOI: 10.1136/gut.47.4.514

Changing trends in the epidemiology of IBD provide an opportunity to examine possible etiological hypotheses. Why did IBD emerge in developed nations in the middle of the 20th century? Why did it emerge initially as ulcerative colitis but now Crohn's disease has become the predominate form of IBD in developed …

Psychosocial aspects of inflammatory bowel disease

Publication Year: 2000 Source: Biomed Pharmacother PMID: 10989978 DOI: 10.1016/S0753-3322(01)80006-8

Inflammatory bowel disease (IBD) includes two clinical subtypes: Crohn disease (CD) and ulcerative colitis (UC). The general prevalence is about 1.0-2.0 % in Western countries. It is predominantly regarded as a multifactorial disorder involving environmental factors and polygenic defects. The view was confirmed by a lot of evidences from clinical …

Thiol-mediated redox regulation of intestinal lamina propria T lymphocytes

Publication Year: 2000 Source: J Exp Med PMID: 10993921 DOI: 10.1084/jem.192.6.907

Comment in Curr Gastroenterol Rep. 2000 Oct;2(5):353. BACKGROUND & AIMS: Prediction of relapse of inflammatory bowel disease has important implications for therapeutic strategies. We assessed whether measurement of intestinal permeability and inflammation could predict relapse of inflammatory bowel disease (IBD). METHODS: Forty-three patients with Crohn's disease (CD) and 37 with …

Presence of bacterial 16S ribosomal RNA gene segments in human intestinal lymph follicles

Publication Year: 2000 Source: Scand J Gastroenterol PMID: 10994621 DOI: 10.1080/003655200750023192

OBJECTIVES: To predict health care utilization in patients with inflammatory bowel disease (IBD). METHODS: The health care utilization of 222 consecutive IBD patients was studied twice over the course of one year. Utilization consisted of medical care, including visits to the gastroenterologist and the general practitioner, and non-medical care, including …

Oral administration of inducible nitric oxide synthase inhibitors reduces nitric oxide synthesis but has no effect on the severity of experimental colitis

Publication Year: 2000 Source: Scand J Gastroenterol PMID: 10994622 DOI: 10.1080/003655200750023200

BACKGROUND: Ursodeoxycholic acid (UDCA) has been shown to be beneficial in reducing disease activity in adult patients with primary sclerosing cholangitis (PSC). However, there has been little published regarding PSC in children and no studies investigating the efficacy of UDCA as a treatment for PSC. METHODS: This retrospective study included …

The epidemiology and the pathogenesis of inflammatory bowel disease

Publication Year: 2000 Source: Eur J Radiol PMID: 11000558 DOI: 10.1016/s0720-048x(00)00238-2

Spontaneous inflammatory bowel disease (IBD) resembling human ulcerative colitis develops in mice mutant for the T cell receptor alpha gene (TCR-alpha-/-). TCR-alpha-/- mice lack TCR-alpha/beta+ cells but contain TCR-gamma/delta+ cells and a small population of a unique CD4+, TCR-alpha-/beta+(low) cells. Since all the immunoglobulin (Ig) classes are present in these …

The role of nuclear medicine in inflammatory bowel disease. A review with experiences of aspecific bowel activity using immunoscintigraphy with 99mTc anti-granulocyte antibodies

Publication Year: 2000 Source: Eur J Radiol PMID: 11000561 DOI: 10.1016/s0720-048x(00)00241-2

BACKGROUND: Concentrations of pro-inflammatory cytokines are increased in the intestinal mucosa of patients with active inflammatory bowel disease (IBD). Polymorphonuclear neutrophil granulocytes (PMN) are the most abundant cell type in intestinal lesions in IBD. Interleukin 10 (IL-10) is an important contra-inflammatory cytokine which induces downregulation of pro-inflammatory cytokines. AIMS: To …

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