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Two-stage global search designs for linkage analysis I: use of the mean statistic for affected sib pairs
Publication Year: 2000 Source: Genet Epidemiol PMID: 10642424 DOI: 10.1002/(SICI)1098-2272(200002)18:2<97::AID-GEPI1>3.0.CO;2-J
Not found
Immunohistochemical analysis of the distribution of measles related antigen in the intestinal mucosa in inflammatory bowel disease
Publication Year: 2000 Source: Gut PMID: 10644308 DOI: 10.1136/gut.46.2.163
We have conducted a genome screen of autism, by linkage analysis in an initial set of 90 multiplex sibships, with parents, containing 97 independent affected sib pairs (ASPs), with follow-up in 49 additional multiplex sibships, containing 50 ASPs. In total, 519 markers were genotyped, including 362 for the initial screen, …
Clinical phenotype is related to HLA genotype in the peripheral arthropathies of inflammatory bowel disease
Publication Year: 2000 Source: Gastroenterology PMID: 10648455 DOI: 10.1016/s0016-5085(00)70209-5
Inflammatory bowel diseases (IBDs), including Crohn's disease and ulcerative colitis, are systemic diseases with a variety of extra-intestinal manifestations. Respiratory involvement, whether clinically symptomatic or latent, may be more common than previously thought. As opposed to adults, most of the cases in children involve Crohn's disease. The pathogeneses of the …
High multidrug resistance (P-glycoprotein 170) expression in inflammatory bowel disease patients who fail medical therapy
Publication Year: 2000 Source: Gastroenterology PMID: 10648456 DOI: 10.1016/s0016-5085(00)70210-1
T cell receptor alpha chain-deficient (TCR-alpha(-/-)) mice are known to spontaneously develop inflammatory bowel disease (IBD). The colitis that develops in these mice is associated with increased numbers of T helper cell (Th)2-type CD4(+)TCR-betabeta (CD4(+)betabeta) T cells producing predominantly interleukin (IL)-4. To investigate the role of these Th2-type CD4(+)betabeta T …
Mycophenolate mofetil: lack of efficacy in chronic active inflammatory bowel disease
Publication Year: 2000 Source: Aliment Pharmacol Ther PMID: 10651657 DOI: 10.1046/j.1365-2036.2000.00695.x
Helicobacter bilis has been isolated from aged inbred mice with multifocal chronic hepatitis and from scid mice with diarrhea, proliferative typhlitis, and colitis. To determine the pathogenic potential of H. bilis, we inoculated 4-week-old female Tac:Icr:Ha(ICR)-scidfDF mice by intraperitoneal injection of approximately 10(8) CFU of H. bilis in phosphate-buffered saline …
IOIBD questionnaire on the clinical use of azathioprine, 6-mercaptopurine, cyclosporin A and methotrexate in the treatment of inflammatory bowel diseases
Publication Year: 2000 Source: Eur J Gastroenterol Hepatol PMID: 10656204 DOI: 10.1097/00042737-200012010-00004
BACKGROUND: Reactive oxygen and nitrogen derived species produced by activated neutrophils have been implicated in the damage of mucosal proteins including the inhibition of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) in the active inflammatory lesion in patients with inflammatory bowel disease (IBD). This study investigated the efficacy of currently used IBD therapeutics to …
Inflammatory bowel disease in Iceland, 1990-1994: a prospective, nationwide, epidemiological study
Publication Year: 2000 Source: Eur J Gastroenterol Hepatol PMID: 10656207 DOI: 10.1097/00042737-200012010-00007
Comment in Am J Gastroenterol. 2001 Oct;96(10):3036-7. OBJECTIVE: Epstein-Barr virus (EBV)-infected cells can evoke severe host immune responses, as shown in infectious mononucleosis and EBV-associated gastric carcinoma. To investigate the possible pathological role of EBV in inflammatory bowel disease (IBD), we tested for the presence of EBV in the colon …
Patient knowledge and educational needs in irritable bowel syndrome
Publication Year: 2000 Source: Eur J Gastroenterol Hepatol PMID: 10656208 DOI: 10.1097/00042737-200012010-00008
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[Immunopathogenesis of inflammatory bowel diseases]
Publication Year: 2000 Source: Chirurg PMID: 10662999 DOI: 10.1007/s001040050005
BACKGROUND: Increased levels of circulating von Willebrand factor (vWF) have been found in patients with inflammatory bowel disease (IBD); this increase may reflect either endothelial damage or systemic inflammation. Our aim was to evaluate serum vWF levels in patients with IBD and their correlation with clinical and biochemical disease activity. …
Analysis of single-nucleotide polymorphisms in the interleukin-4 receptor gene for association with inflammatory bowel disease
Publication Year: 2000 Source: Immunogenetics PMID: 10663555 DOI: 10.1007/s002510050001
A germline sequence alteration at codon 1307 of the APC gene (I1307K) has been reported in 6-7% of the Ashkenazi Jewish population in the United States. This alteration is believed to predispose the APC gene to a secondary mutation at the same locus, resulting in an increased risk of colorectal …
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