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The C3H/HeJBir mouse model: a high susceptibility phenotype for colitis
Publication Year: 2000 Source: Int Rev Immunol PMID: 10723678 DOI: 10.3109/08830180009048390
The understanding of the pathogenesis of CD and UC has greatly expanded over the last decade. The combination of abnormalities in the immune system, the contribution of nonimmune cells in the intestinal mucosa, a variety of genetic risk determinants, and random environmental factors may all be necessary to induce what …
IL-15 is highly expressed in inflammatory bowel disease and regulates local T cell-dependent cytokine production
Publication Year: 2000 Source: J Immunol PMID: 10725717 DOI: 10.4049/jimmunol.164.7.3608
OBJECTIVE: The mechanism of bone loss in patients with inflammatory bowel disease (IBD) is not completely understood. The aim of this study was to assess indices of bone turnover and bone mineral density (BMD) in the lumbar spine and femoral neck in IBD patients. METHODS: Sixty-three patients with Crohn's disease …
Altered IgG(4) renal clearance in patients with inflammatory bowel diseases. Evidence for a subclinical impairment of protein charge renal selectivity
Publication Year: 2000 Source: Nephrol Dial Transplant PMID: 10727544 DOI: 10.1093/ndt/15.4.498
NK cells are a major component of the innate immune system and play an important role in the tissue inflammation associated with autoimmune diseases such as inflammatory bowel disease (IBD). NK cells are unique in bearing both stimulatory and inhibitory receptors specific for MHC class I molecules, and their function …
Risk of cancer in inflammatory bowel disease (IBD)
Publication Year: 2000 Source: Eur J Intern Med PMID: 10745149 DOI: 10.1016/s0953-6205(00)00061-3
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Thrombomodulin as a marker of endothelium damage in some clinical conditions
Publication Year: 2000 Source: Eur J Intern Med PMID: 10745150 DOI: 10.1016/s0953-6205(00)00066-2
Presenting symptoms and their duration may affect the time that elapses prior to definitive diagnosis of inflammatory bowel disease (IBD). This study was undertaken to determine the mean duration of presenting symptoms and diagnostic lag in children with IBD. The medical records of all patients less than 19 years of …
High-density genome scan in Crohn disease shows confirmed linkage to chromosome 14q11-12
Publication Year: 2000 Source: Am J Hum Genet PMID: 10747815 DOI: 10.1086/302947
Comment in Gastroenterology. 1998 Nov;115(5):1286-9. BACKGROUND & AIMS: Evidence of kinin-mediated inflammation in the gastrointestinal tract is accumulating. The genes and some polymorphic sites have been characterized for both kinin B1 and B2 receptors. These candidate genes were studied for their possible association with inflammatory bowel disease (IBD). METHODS: In …
Inflammatory bowel disease in children and adolescents in Sweden, 1984-1995
Publication Year: 2000 Source: J Pediatr Gastroenterol Nutr PMID: 10749408 DOI: 10.1097/00005176-200003000-00009
BACKGROUND: Research in chronic illness shows that community resources can have a lasting influence on the course of the illness; however, little research has been done to evaluate the community agencies that specifically address the needs of inflammatory bowel disease (IBD) patients. OBJECTIVES: To survey awareness of community agency resources …
Circulating levels of glucagon-like peptide-2 in human subjects with inflammatory bowel disease
Publication Year: 2000 Source: Am J Physiol Regul Integr Comp Physiol PMID: 10749795 DOI: 10.1152/ajpregu.2000.278.4.R1057
OBJECTIVE: The analysis of the time trends of inflammatory bowel disease (IBD) is a powerful research tool to assess the contribution of environmental factors to its etiology and to gain insights about possible causative mechanisms. A previous study revealed a characteristic relationship between the time trends of mortality from Crohn's …
Oxidant-induced intestinal barrier disruption and its prevention by growth factors in a human colonic cell line: role of the microtubule cytoskeleton
Publication Year: 2000 Source: Free Radic Biol Med PMID: 10754268 DOI: 10.1016/s0891-5849(00)00160-x
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A method for culturing and transplanting biliary epithelial cell from syrian golden hamster
Publication Year: 2000 Source: Virchows Arch PMID: 10755605 DOI: 10.1007/pl00008214
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