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Allergic reactions to 6-mercaptopurine during treatment of inflammatory bowel disease

Publication Year: 1999 Source: J Clin Gastroenterol PMID: 10372932 DOI: 10.1097/00004836-199906000-00011

Crohn's disease (CD) and ulcerative colitis (UC) are inflammatory bowel diseases (IBD) of unknown etiology. Oral absorption studies have shown an increased intestinal permeability for various sugar molecules in patients with IBD and their healthy relatives as a possible pathogenetic factor. However, the various transport pathways through the mucosal barrier …

IL1B gene polymorphisms influence the course and severity of inflammatory bowel disease

Publication Year: 1999 Source: Immunogenetics PMID: 10380697 DOI: 10.1007/s002510050530

Involvement of mucosal cells in inflammatory bowel disease (IBD) may be a sequenced process and the molecular difference between involved and uninvolved cells might implicate a possible mechanism in the disease process. The aim of this study was to compare gene expression between involved and uninvolved colonic mucosa cells in …

Rectal cancer and inflammatory bowel disease: natural history and implications for radiation therapy

Publication Year: 1999 Source: Int J Radiat Oncol Biol Phys PMID: 10386640 DOI: 10.1016/s0360-3016(99)00091-7

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Probability of identity by descent in metapopulations

Publication Year: 1999 Source: Genetics PMID: 10388835 DOI: 10.1093/genetics/152.3.1217

All individuals in a finite population are related if traced back long enough and will, therefore, share regions of their genomes identical by descent (IBD). Detection of such regions has several important applications-from answering questions about human evolution to locating regions in the human genome containing disease-causing variants. However, IBD …

NF-kappaB in IBD: does binding to DNA imply transcriptional activity?

Publication Year: 1999 Source: Gastroenterology PMID: 10391740 DOI: 10.1016/s0016-5085(99)70523-8

OBJECTIVE: Inflammatory bowel disease (IBD) is a gastrointestinal system disorder with a variety of causes. The prevalence of reduced bone mineral density (BMD) is greater in people with IBD as compared with healthy individuals. In this study, we aimed to investigate the possible risk factors for low BMD in subjects …

Coincidence of Crohn's disease and a high-risk gastrointestinal stromal tumor of the terminal ileum

Publication Year: 1999 Source: Digestion PMID: 10394032 DOI: 10.1159/000007684

Total colonoscopy is arguably the best method available for examination of the colon and rectum. Colonoscopy costs are high and rising and it may be that in the future practitioners will be unable to afford to colonoscope all of the patients presently being examined. This retrospective study was undertaken in …

Generation of 'truncated' interleukin-6 receptor (IL-6R) mRNA by alternative splicing; a possible source of soluble IL-6R

Publication Year: 1999 Source: Immunol Lett PMID: 10397166 DOI: 10.1016/s0165-2478(99)00040-1

The accuracy of computed tomography (CT) and [99mTc]HMPAO granulocyte scintigraphy (GS) for detection of bowel localization, inflammatory activity, and complications in acute inflammatory bowel disease (IBD) was prospectively studied in 32 patients. Of each bowel segment, findings on CT and GS were scored by one blinded observer. Findings on operation …

Characterization of Mycobacterium paratuberculosis p36 antigen and its seroreactivities in Crohn's disease

Publication Year: 1999 Source: Curr Microbiol PMID: 10398839 DOI: 10.1007/s002849900430

PSC is the most common of the clinically significant hepatobiliary diseases seen in association with IBD, with an incidence that varies from 2.5% to 7.5%. Conversely, 50% to 75% of patients with PSC have IBD. This high degree of association suggests a common pathogenetic mechanism; however, no causal relationship has …

Concordance between abdominal scintigraphy using technetium-99m hexamethylpropylene amine oxime-labelled leucocytes and ileocolonoscopy in patients with spondyloarthropathies and without clinical evidence of inflammatory bowel disease

Publication Year: 1999 Source: Rheumatology (Oxford) PMID: 10402075 DOI: 10.1093/rheumatology/38.6.543

Comment in Gut. 1994 Nov;35(11):1675-6. Increased intestinal permeability in patients with Crohn's disease and their first degree relatives has been proposed as an aetiological factor. The nine hour overnight urinary excretion of polyethyleneglycol-400 (PEG-400) and three inert sugars (lactulose, l-rhamnose, and mannitol) was used to test the permeation in 47 …

Gender specific alterations of body composition in patients with inflammatory bowel disease compared with controls

Publication Year: 1999 Source: Eur J Clin Nutr PMID: 10403585 DOI: 10.1038/sj.ejcn.1600780

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