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Longitudinal changes in radial bone density in older men
Publication Year: 1999 Source: Eur J Clin Nutr PMID: 10201803 DOI: 10.1038/sj.ejcn.1600703
Epithelial cell (EC) injury is a feature of all inflammatory bowel disorders (IBD). Although the mechanisms of EC injury are incompletely understood, it has been proposed that T-cell-mediated cytotoxicity and production of inflammatory cytokines are involved. This hypothesis was tested using the interleukin 2-deficient (IL2-/-) mouse model of IBD and …
Quality of life in inflammatory bowel disease: background and definitions
Publication Year: 1999 Source: J Pediatr Gastroenterol Nutr PMID: 10204518 DOI: 10.1097/00005176-199904001-00001
Osteopenia or osteoporosis is common in patients with inflammatory bowel disease. The use of corticosteroids contributes to the decline in bone loss; however, osteoporosis may develop in patients with inflammatory bowel disease independent of corticosteroid use. Risk factors for the development of low bone mass in patients with inflammatory bowel …
Development of a quality-of-life index for pediatric inflammatory bowel disease: dealing with differences related to age and IBD type
Publication Year: 1999 Source: J Pediatr Gastroenterol Nutr PMID: 10204526 DOI: 10.1097/00005176-199904001-00009
BACKGROUND: Inflammatory bowel disease (IBD) is characterized by chronic inflammation of the gastrointestinal tract. Epstein-Barr virus (EBV) infection is associated with increased disease severity in therapeutically immunosuppressed IBD patients. The role of EBV infection in patients with IBD who are unresponsive to medical therapy is unclear. Anti-viral strategies may be …
Assessment of quality of life in the younger child: the use of an animated computer program
Publication Year: 1999 Source: J Pediatr Gastroenterol Nutr PMID: 10204527 DOI: 10.1097/00005176-199904001-00010
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Phospholipid turnover in the inflamed intestinal mucosa: arachidonic acid-rich phosphatidyl/plasmenyl-ethanolamine in the mucosa in inflammatory bowel disease
Publication Year: 1999 Source: J Gastroenterol PMID: 10204610 DOI: 10.1007/s005350050215
An increasing body of evidence supports the concept of genetic heterogeneity within inflammatory bowel disease (IBD). In this study, a polymorphism of the motilin gene, which determines an amino acid substitution in the motilin protein, has been investigated in IBD patients. Fifty patients with ulcerative colitis (UC), and 52 with …
Mucosal proinflammatory cytokine production correlates with endoscopic activity of ulcerative colitis
Publication Year: 1999 Source: J Gastroenterol PMID: 10204613 DOI: 10.1007/s005350050218
Leukocyte scintigraphy has been used as a standard diagnostic procedure for the detection of inflammation in vivo. In this study, we developed a method of labelling purified lymphocytes with technetium99m-hexamethyl propyleneamine oxime (Tc99m-HMPAO) without significantly impairing their function. This was confirmed by measurements of in vitro lymphocyte adhesion and migration …
Proinflammatory cytokines in IBD
Publication Year: 1999 Source: J Gastroenterol PMID: 10204629 DOI: 10.1007/s005350050234
We evaluated the combined use of different fixatives for the identification of atypical perinuclear anti-neutrophil cytoplasmic antibodies (p-ANCA) in patients with inflammatory bowel diseases (IBD) by indirect immunofluorescence (IIF). Sera from 59 ulcerative colitis (UC) and 37 Crohn's disease (CD) patients, and from 64 healthy controls were studied. The IIF …
Prevention of both T2- and diffusion-weighted increases in image intensity during cerebral hypoxia-ischemia in infant rats pretreated with dexamethasone
Publication Year: 1999 Source: Exp Brain Res PMID: 10204774 DOI: 10.1007/s002210050676
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Enhanced production of monocyte chemotactic protein 3 in inflammatory bowel disease mucosa
Publication Year: 1999 Source: Gut PMID: 10205198 DOI: 10.1136/gut.44.5.629
Comment in J Gastroenterol. 1999 Feb;34(1):149-51. Proinflammatory cytokines are believed to be involved in the pathogenesis of ulcerative colitis (UC). The aim of this study was to clarify the profiles of proinflammatory cytokine production in patients with UC in terms of disease intractability, endoscopic findings, and host response to lipopolysaccharide …
Etiology of the inflammatory bowel diseases
Publication Year: 1999 Source: Int J Colorectal Dis PMID: 10207723 DOI: 10.1007/s003840050175
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