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Immunity in digestive diseases: new drugs for inflammatory bowel disease treatment-insights from Phase II and III trials
Publication Year: 2024 Source: J Gastroenterol PMID: 38980426 DOI: 10.1007/s00535-024-02130-x
BACKGROUND: Inflammatory bowel disease (IBD), encompassing Crohn's disease (CD) and ulcerative colitis (UC), continues to challenge treatment paradigms. Advancements in therapeutic options have been have been driven by Phase 2 and 3 clinical trials of new drug classes, particularly sphingosine-1-phosphate (S1P) modulators and interleukin-23 (IL-23) inhibitors. METHODS: This review synthesizes …
[Patient with proctitis: inflammatory bowel disease or infectious disease?]
Publication Year: 2024 Source: MMW Fortschr Med PMID: 38980617
No Abstract
Do patients with inflammatory bowel disease really know what other immune-mediated inflammatory diseases they are diagnosed with?
Publication Year: 2024 Source: J Crohns Colitis PMID: 38980756 DOI: 10.1093/ecco-jcc/jjae109
BACKGROUND AND AIMS: The association of inflammatory bowel disease (IBD) with other immune-mediated inflammatory diseases (IMIDs) in the same patient is well known. We aimed to evaluate the degree of knowledge that patients with IBD have regarding the coexistence of other IMIDs and to analyze the factors associated with the …
Inflammatory bowel disease associated with primary sclerosing cholangitis is associated with an altered gut microbiome and bile acid profile
Publication Year: 2024 Source: J Crohns Colitis PMID: 38980940 DOI: 10.1093/ecco-jcc/jjae096
BACKGROUND: Primary sclerosing cholangitis associated with inflammatory bowel disease (IBD-PSC) carries significant morbidity compared to IBD without PSC. Alterations in microbial composition and bile acid (BA) profiles have been shown to modulate chronic inflammation in IBD, but data in IBD-PSC is scarce. We aimed to assess the differences in gut …
CircHIPK2 Contributes Cell Growth in Intestinal Epithelial of Colitis and Colorectal Cancer through Promoting TAZ Translation
Publication Year: 2024 Source: Adv Sci (Weinh) PMID: 38981023 DOI: 10.1002/advs.202401588
Colorectal cancer (CRC) and inflammatory bowel disease (IBD) are escalating global health concerns. Despite their distinct clinical presentations, both disorders share intricate genetic and molecular interactions. The Hippo signaling pathway plays a crucial role in regulating cell processes and is implicated in the pathogenesis of IBD and CRC. Circular RNAs …
Anti-inflammation mechanisms of a homogeneous polysaccharide from Phyllanthus emblica L. on DSS induced colitis mice via the gut microbiota and metabolites alteration
Publication Year: 2024 Source: Food Chem PMID: 38981378
No Abstract
Risk of anti-TNF therapy on pregnancy, breastfeeding, live vaccines and related information in patients with inflammatory bowel disease: Real-world data from a nationwide study
Publication Year: 2024 Source: Dig Liver Dis PMID: 38981787 DOI: 10.1016/j.dld.2024.06.011
BACKGROUND: Anti-TNF are usually maintained during pregnancy in patients with inflammatory bowel disease (IBD) but safety is still a concern for them. AIMS: To provide data on management of anti-TNF agents during pregnancy, safety of live vaccines (BCG-MMR-rotavirus) and breastfeeding in newborns and dedicated information delivered to IBD women. METHODS: …
Genetic evidence for the causal impact of insomnia on gastrointestinal diseases and the mediating effects of adiposity traits
Publication Year: 2024 Source: J Gastroenterol Hepatol PMID: 38981855 DOI: 10.1111/jgh.16678
BACKGROUND AND AIM: Insomnia has been implicated in gastrointestinal diseases (GIs), but the causal effect between insomnia and GIs and underlying mechanisms remain unknown. METHODS: By using the released summary-level data, we conducted a two-step Mendelian randomization (MR) analysis to examine the relationship between insomnia and four GIs and estimate …
Fibroblast growth factor receptor 4 deficiency in macrophages aggravates experimental colitis by promoting M1-polarization
Publication Year: 2024 Source: Inflamm Res PMID: 38981913 DOI: 10.1007/s00011-024-01910-8
OBJECTIVE AND DESIGN: Compelling evidence indicates that dysregulated macrophages may play a key role in driving inflammation in inflammatory bowel disease (IBD). Fibroblast growth factor (FGF)-19, which is secreted by ileal enterocytes in response to bile acids, has been found to be significantly lower in IBD patients compared to healthy …
Vedolizumab, an α4β7-Integrin Inhibitor, Exacerbates Ulcerative Colitis-Related Spondylitis
Publication Year: 2024 Source: J Clin Rheumatol PMID: 38982566
No Abstract
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