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Pharmacokinetics and Exposure-Response Analyses to Support Dose Selection of Upadacitinib in Crohn's Disease
Publication Year: 2024 Source: Clin Pharmacol Ther PMID: 38982567
No Abstract
Fast-Responsive HClO-Activated Near-Infrared Fluorescent Probe for In Vivo Diagnosis of Inflammatory Bowel Disease and Ex Vivo Optical Fecal Analysis
Publication Year: 2024 Source: Anal Chem PMID: 38982573 DOI: 10.1021/acs.analchem.4c02130
Inflammatory bowel disease (IBD) is an idiopathic intestinal inflammatory disease, whose etiology is intimately related to the overproduction of hypochlorous acid (HClO). Optical monitoring of HClO in the living body favors real-time diagnosis of inflammatory diseases. However, HClO-activated near-infrared (NIR) fluorescent probes with rapid response and high inflammatory cell uptake …
Treatment of Active Crohn's Disease With Exclusive Enteral Nutrition Diminishes the Immunostimulatory Potential of Fecal Microbial Products
Publication Year: 2024 Source: Inflamm Bowel Dis PMID: 38982655
No Abstract
Intracellular Polysaccharides of Eurotium cristatum Exhibited Anticolitis Effects in Association with Gut Tryptophan Metabolism
Publication Year: 2024 Source: J Agric Food Chem PMID: 38982686
No Abstract
Phenotypes of inflammatory bowel disease in the Māori population of New Zealand
Publication Year: 2024 Source: Intern Med J PMID: 38982857 DOI: 10.1111/imj.16416
BACKGROUND: Maori have historically seen a lower rate of inflammatory bowel disease (IBD) compared to New Zealand's non-Maori population. Recent reports have shown an increasing rate of IBD among Maori patients. AIM: We performed a study to identify the phenotypes of IBD in the Maori population. METHODS: Patients with IBD …
Improved high-performance liquid chromatography tandem mass spectrometry method for quantification of infliximab in pediatric plasma and its application in therapeutic drug monitoring
Publication Year: 2024 Source: Rapid Commun Mass Spectrom PMID: 38982886 DOI: 10.1002/rcm.9865
RATIONALE: The application of infliximab (IFX) to immune-mediated disease is limited by the significant individual variability and associated clinical nonresponse, emphasizing the importance of therapeutic drug monitoring (TDM). Because of the cross-reactivity, limited linear range, and high costs, the clinical application of the previous reported methods was limited. Here, an …
Ocular extraintestinal manifestations and treatments in patients with inflammatory bowel disease
Publication Year: 2024 Source: Front Ophthalmol (Lausanne) PMID: 38983096 DOI: 10.3389/fopht.2023.1257068
Between 3-47% of patients with inflammatory bowel disease (IBD) have extraintestinal manifestations (EIMs), and between 1.3-86.9% of patients with IBD suffer from ocular EIMs (O-EIMs) making the eye the third most common organ affected. These O-EIMs exist among a spectrum, with a variety of types and amounts of inflammation which …
Global geoepidemiology of gastrointestinal surgery rates in Crohn's disease
Publication Year: 2024 Source: World J Gastrointest Surg PMID: 38983343
No Abstract
From the mathematical model to the patient: The scientific and human aspects of artificial intelligence in gastrointestinal surgery
Publication Year: 2024 Source: World J Gastrointest Surg PMID: 38983356 DOI: 10.4240/wjgs.v16.i6.1517
Recent medical literature shows that the application of artificial intelligence (AI) models in gastrointestinal pathology is an exponentially growing field, with promising models that show very high performances. Regarding inflammatory bowel disease (IBD), recent reviews demonstrate promising diagnostic and prognostic AI models. However, studies are generally at high risk of …
A correlation of serum fibroblast growth factor 21 level with inflammatory markers and indicators of nutritional status in patients with inflammatory bowel disease
Publication Year: 2024 Source: Front Physiol PMID: 38983722 DOI: 10.3389/fphys.2024.1394030
BACKGROUND: Fibroblast growth factor 21 (FGF21) is a stress-inducible hormone that regulates nutrient and metabolic homeostasis. Inflammatory state is one of the stimulators of FGF21 secretion. The aim of the study was to assess correlations between serum FGF21 level and inflammatory markers as well as nutritional status indicators in patients …
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