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Viral vectors expressing immunoregulatory cytokines to treat inflammatory bowel disease
Publication Year: 1998 Source: Gut PMID: 9616304 DOI: 10.1136/gut.42.4.460
To test the hypothesis that a gene (or genes) in the "MODY1 region" of the long arm of chromosome 20 contributes to the development of NIDDM, we conducted linkage studies in 29 extended Caucasian families in which many members were affected with NIDDM. A total of 498 individuals, including 159 …
Increased secretion of pro-inflammatory cytokines by circulating polymorphonuclear neutrophils and regulation by interleukin 10 during intestinal inflammation
Publication Year: 1998 Source: Gut PMID: 9616306 DOI: 10.1136/gut.42.4.470
Not fully defined pathophysiologic mechanisms of inflammatory bowel disease (IBD) involve an array of genetic, epigenetic, infectious, physiological and immunological factors. Nowadays, an inadequate activation of the innate immune system to a luminal factor occurring in genetically predisposed subjects is the most widely accepted today. Micro-autoimmune diseases, a group of …
Activation of nuclear factor kappa B inflammatory bowel disease
Publication Year: 1998 Source: Gut PMID: 9616307 DOI: 10.1136/gut.42.4.477
Endoscopy in IBD has tremendous importance to diagnose inflammatory activity, to evaluate therapeutic success and for the surveillance of colitis associated cancer. Thus it becomes obvious that there is a need for new and more advanced endoscopic imaging techniques for better characterization of mucosal inflammation and early neoplasia detection in …
Impairment of intestinal glutathione synthesis in patients with inflammatory bowel disease
Publication Year: 1998 Source: Gut PMID: 9616308 DOI: 10.1136/gut.42.4.485
BACKGROUND: We performed a cross-sectional study to evaluate the prevalence of hepatobiliary disease in unselected patients with inflammatory bowel disease (IBD), to estimate the frequency of coexisting cholangiographic and pancreatographic duct abnormalities, and to correlate the findings with clinical, endoscopic, and histologic variables. METHODS: We screened 237 IBD patients for …
Infrared spectroscopic analysis of biomedical specimens using glass substrates
Publication Year: 1998 Source: Anal Biochem PMID: 9618195 DOI: 10.1006/abio.1998.2654
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Evidence for a new type of outer membrane lipid in oral spirochete Treponema denticola. Functioning permeation barrier without lipopolysaccharides
Publication Year: 1998 Source: J Biol Chem PMID: 9624160 DOI: 10.1074/jbc.273.25.15661
BACKGROUND & AIMS: In patients with severe corticosteroid-refractory ulcerative colitis, cyclosporine or infliximab may be added in an effort to induce remission. If the patient then fails either of these drugs, it is unknown whether success can be achieved by using the other agent. The aim of this study was …
Complementary medicine use by patients with inflammatory bowel disease
Publication Year: 1998 Source: Am J Gastroenterol PMID: 9625111 DOI: 10.1111/j.1572-0241.1998.208_a.x
Multipoint linkage analysis of quantitative-trait loci (QTLs) has previously been restricted to sibships and small pedigrees. In this article, we show how variance-component linkage methods can be used in pedigrees of arbitrary size and complexity, and we develop a general framework for multipoint identity-by-descent (IBD) probability calculations. We extend the …
Expression of inducible nitric oxide synthase (iNOS) mRNA in inflamed esophageal and colonic mucosa in a pediatric population
Publication Year: 1998 Source: Am J Gastroenterol PMID: 9625130 DOI: 10.1111/j.1572-0241.1998.227_a.x
Not found
Maintenance treatment of ulcerative proctitis with mesalazine suppositories: a double-blind placebo-controlled trial. The Italian IBD Study Group
Publication Year: 1998 Source: Am J Gastroenterol PMID: 9625131 DOI: 10.1111/j.1572-0241.1998.228_a.x
Inflammatory bowel disease is a chronic inflammatory disorder of the gastrointestinal tract that includes ulcerative colitis and Crohn's disease. Leukotriene B4 is thought to be a prominent proinflammatory mediator in these diseases, in that leukotriene B4 levels are increased in the colonic mucosa of inflammatory bowel disease patients and there …
Neuroimmunomodulation in inflammatory bowel disease. How far from "bench" to "bedside"?
Publication Year: 1998 Source: Ann N Y Acad Sci PMID: 9629299 DOI: 10.1111/j.1749-6632.1998.tb09611.x
Toll-like receptor 2 (TLR2) is a type I pattern recognition receptor that has been shown to participate in intestinal homeostasis. Its increased expression in the lamina propria has been associated with the pathogenesis in inflammatory bowel disease (IBD), such as ulcerative colitis (UC) and Crohn's disease (CD). Recently, soluble TLR2 …
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