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Spondylarthropathies: from gut to target organs

Publication Year: 1996 Source: Baillieres Clin Rheumatol PMID: 8674144 DOI: 10.1016/s0950-3579(96)80009-4

Not found

Course of gut inflammation in spondylarthropathies and therapeutic consequences

Publication Year: 1996 Source: Baillieres Clin Rheumatol PMID: 8674145 DOI: 10.1016/s0950-3579(96)80010-0

Not found

Computed tomography and granulocyte scintigraphy in active inflammatory bowel disease. Comparison with endoscopy and operative findings

Publication Year: 1996 Source: Dig Dis Sci PMID: 8674383 DOI: 10.1007/BF02213118

Inheritance of T cell receptor beta chain (TCR beta) genes was analyzed in families of 40 sibling pairs concordant for the relapsing-remitting form of multiple sclerosis (MS). TCR beta haplotypes were determined by segregation analysis of polymorphic markers within the TCR beta complex. The mean proportion of TCR beta haplotypes …

Expression of protooncogene-encoded mRNA by colonic epithelial cells in inflammatory bowel disease

Publication Year: 1996 Source: Dig Dis Sci PMID: 8674385 DOI: 10.1007/BF02213120

Saccharomyces boulardii (Sb) is a probiotic yeast that has demonstrated efficacy in pilot studies in patients with inflammatory bowel disease (IBD). Microbial antigen handling by dendritic cells (DC) is believed to be of critical importance for immunity and tolerance in IBD. The aim was to characterize the effects of Sb …

Mucosal antibodies in inflammatory bowel disease are directed against intestinal bacteria

Publication Year: 1996 Source: Gut PMID: 8675088 DOI: 10.1136/gut.38.3.365

OBJECTIVES: Reactivation of a latent cytomegalovirus (CMV) may occur in inflammatory bowel disease (IBD). Data of human herpesvirus 6 (HHV-6)--a close relative to CMV--in active IBD are scarce. The aim of this study was to detect HHV-6 and CMV antigens in the mucosa of active and inactive IBD. MATERIAL AND …

The basis of current and future therapy for inflammatory bowel disease

Publication Year: 1996 Source: Am J Med PMID: 8678087 DOI: 10.1016/s0002-9343(96)00049-6

In rodents, intracolonic administration of ethanol 30% induces an acute colitis, while administration of 2,4,6-trinitrobenzene sulphonic acid (TNBS) in ethanol induces a longer lasting colitis. In the acute and chronic stages of experimental colitis, lymphoid and non-lymphoid cells were studied in the colon by immunohistochemistry. During the acute inflammation a …

Influence of inflammatory bowel disease on the ability of patients to tolerate systemic fluorouracil-based chemotherapy

Publication Year: 1996 Source: J Clin Oncol PMID: 8683234 DOI: 10.1200/JCO.1996.14.7.2043

Hepatic abscesses are a rare complication of inflammatory bowel disease (IBD). Despite the fact that certain hepatobiliary complications of IBD, including cholelithiasis, primary sclerosing cholangitis (PSC) and cholangiocarcinoma predispose patients with IBD to ascending cholangitis, previously published data does not demonstrate that biliary infection is an important mechanism underlying liver …

Differential in situ expression of the genes encoding the chemokines MCP-1 and RANTES in human inflammatory bowel disease

Publication Year: 1996 Source: J Pathol PMID: 8683390 DOI: 10.1002/(SICI)1096-9896(199602)178:2<201::AID-PATH440>3.0.CO;2-4

Crohn's disease (CD) and ulcerative colitis (UC) represent clinically distinct chronic inflammatory bowel diseases (IBD) of unknown etiology. Although the mucosal immune system is implicated in their pathogenesis, immunological differences between the two disorders are not well defined. The aim of this study was to compare in vitro mucosal T-lymphocyte …

Evidence of oxidant-induced injury to epithelial cells during inflammatory bowel disease

Publication Year: 1996 Source: J Clin Invest PMID: 8690784 DOI: 10.1172/JCI118757

Transfer of 2 x 10(5) congenic or semiallogenic purified TCR alphabeta+ CD4+ T cells to SCID mice leads to an infiltration of the recipient gut lamina propria and epithelium with a donor-derived CD4+ T cell subset which induces a lethal inflammatory bowel disease (IBD) in the recipients. In contrast, IBD …

T helper cell 1-type CD4+ T cells, but not B cells, mediate colitis in interleukin 10-deficient mice

Publication Year: 1996 Source: J Exp Med PMID: 8691138 DOI: 10.1084/jem.184.1.241

The objective of this study was to examine the effects of dietary n-6:n-3 ratio on immune and reproduction systems of Leghorn pullet chicks. A total of 216 Hy-Line W-36 pullet chicks (1 d old) were randomly assigned to 3 diets (n-6:n-3 ratios of 10, 6, and 2) until 22 wk …

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