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Fibrogenesis in Human Mucosa and Muscularis Precision-Cut Intestinal Slices
Publication Year: 2024 Source: Cells PMID: 38994938
No Abstract
Intestinal biofilms: pathophysiological relevance, host defense, and therapeutic opportunities
Publication Year: 2024 Source: Clin Microbiol Rev PMID: 38995034 DOI: 10.1128/cmr.00133-23
SUMMARYThe human intestinal tract harbors a profound variety of microorganisms that live in symbiosis with the host and each other. It is a complex and highly dynamic environment whose homeostasis directly relates to human health. Dysbiosis of the gut microbiota and polymicrobial biofilms have been associated with gastrointestinal diseases, including …
The role of fecal biomarkers in individuals with inflammatory bowel disease
Publication Year: 2024 Source: Expert Rev Mol Diagn PMID: 38995110 DOI: 10.1080/14737159.2024.2375224
INTRODUCTION: Inflammatory bowel disease (IBD), encompassing Crohn's disease (CD) and Ulcerative Colitis (UC), is a relapsing and remitting condition. Noninvasive biomarkers have an increasingly important role in the diagnosis of IBD and in the prediction of future disease course in individuals with IBD. Strategies for the management of IBD increasingly …
Mendelian randomization analysis of psoriasis and psoriatic arthritis associated with risks of ulcerative colitis
Publication Year: 2024 Source: Skin Res Technol PMID: 38995229
No Abstract
Serum calgranulin C as a non-invasive predictor of activity among inflammatory bowel disease
Publication Year: 2024 Source: Egypt J Immunol PMID: 38995671
No Abstract
Orally administrated liquid metal agents for inflammation-targeted alleviation of inflammatory bowel diseases
Publication Year: 2024 Source: Sci Adv PMID: 38996026
No Abstract
Beyond the lungs: Exploring diverse applications of bromhexine and ambroxol
Publication Year: 2024 Source: Life Sci PMID: 38997062
No Abstract
Cyclic adenosine 3', 5'-monophosphate (cAMP) signaling is a crucial therapeutic target for ulcerative colitis
Publication Year: 2024 Source: Life Sci PMID: 38997063
No Abstract
Therapeutic potential of the secreted Kazal-type serine protease inhibitor SPINK4 in colitis
Publication Year: 2024 Source: Nat Commun PMID: 38997284 DOI: 10.1038/s41467-024-50048-y
Mucus injury associated with goblet cell (GC) depletion constitutes an early event in inflammatory bowel disease (IBD). Using single-cell sequencing to detect critical events in mucus dysfunction, we discover that the Kazal-type serine protease inhibitor SPINK4 is dynamically regulated in colitic intestine in parallel with disease activities. Under chemically induced …
Development and preliminary evaluation of a suicidal risk assessment protocol in a randomised controlled trial using the Patient Health Questionnaire (PHQ-9)
Publication Year: 2024 Source: Trials PMID: 38997767 DOI: 10.1186/s13063-024-08276-6
BACKGROUND: Participants in research trials often disclose severe depression symptoms, including thoughts of self-harm and suicidal ideation, in validated self-administered questionnaires such as the Patient Health Questionnaire (PHQ-9). However, there is no standard protocol for responding to such disclosure, and the opportunity to support people at risk is potentially missed. …
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