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The many roles of chemokines and chemokine receptors in inflammation.
Publication Year: Unknown Source: The New England journal of medicine PMID: 16467548
No Abstract
Review article: smoking cessation as primary therapy to modify the course of Crohn's disease.
Publication Year: Unknown Source: Alimentary pharmacology & therapeutics PMID: 15813828
This article aims to offer an updated review of the effects of smoking on inflammatory bowel disease, and provide a review of the methods of achieving smoking cessation. A systematic review of Embase and Medline databases was conducted. Smoking causes opposing effects on ulcerative colitis and Crohn's disease. The odds …
Colonic vasoactive intestinal peptide nerves in inflammatory bowel disease.
Publication Year: Unknown Source: Gastroenterology PMID: 1551531
Vasoactive intestinal peptide is a neuropeptide with potent modulatory activity on intestinal immunity and may be implicated in the pathogenesis of inflammatory bowel disease (IBD). Previous studies have reported abnormal morphology of vasoactive intestinal peptide-stained enteric nerves, in addition to increased, normal or decreased levels of extractable peptide in Crohn's …
Evidence for function of Ia molecules on gut epithelial cells in man.
Publication Year: Unknown Source: The Journal of experimental medicine PMID: 2960770
Using freshly isolated Ia+ gut epithelial cells we have been able to demonstrate that these cells can function as accessory cells in an immune response. The cells can act as stimulators in both autologous and allogeneic MLRs. More importantly, these cells are capable of taking up the soluble antigen, tetanus …
Spontaneous secretion of IgG subclasses by intestinal mononuclear cells: differences between ulcerative colitis, Crohn's disease, and controls.
Publication Year: Unknown Source: Clinical and experimental immunology PMID: 3802572
Spontaneous IgG and IgG subclass secretion patterns by isolated intestinal mononuclear cells (MNC) from control and inflammatory bowel disease (IBD) specimens were examined. Intestinal MNC from IBD specimens spontaneously secreted more total IgG than did control intestinal MNC. This increased spontaneous IgG secretion by ulcerative colitis intestinal MNC was primarily …
Alterations of the intestinal mucosal block in ulcerative colitis and Crohn's disease--immunological and ultrastructural findings, and considerations of the pathogenesis.
Publication Year: Unknown Source: Klinische Padiatrie PMID: 4046492
The intestinal mucosa is the very site of the chronic inflammatory lesion in ulcerative colitis (UC) and in Crohn's disease (CD). The lamina mucosa together with its own and associated cellular and humoral protective properties can be described as the mucosal block which is functionally related to the intestinal and …
Absorption of 51chromium-labeled ethylenediaminetetraacetate in inflammatory bowel disease.
Publication Year: Unknown Source: Gastroenterology PMID: 6407889
Intestinal permeability was assessed in patients with inflammatory bowel disease by measuring the urine excretion of 51chromium-labeled ethylenediaminetetraacetate over periods up to 24 h after oral administration. Twenty-eight control subjects and 10 patients with ulcerative colitis excreted less than 2.6% of the test dose in 24 h. Ten patients with …
Methionine adenosyltransferase 1A knockout mice are predisposed to liver injury and exhibit increased expression of genes involved in proliferation.
Publication Year: Unknown Source: Proceedings of the National Academy of Sciences of the United States of America PMID: 11320206
Liver-specific and nonliver-specific methionine adenosyltransferases (MATs) are products of two genes, MAT1A and MAT2A, respectively, that catalyze the formation of S-adenosylmethionine (AdoMet), the principal biological methyl donor. Mature liver expresses MAT1A, whereas MAT2A is expressed in extrahepatic tissues and is induced during liver growth and dedifferentiation. To examine the influence …
A critical role for the peroxisome proliferator-activated receptor alpha (PPARalpha) in the cellular fasting response: the PPARalpha-null mouse as a model of fatty acid oxidation disorders.
Publication Year: Unknown Source: Proceedings of the National Academy of Sciences of the United States of America PMID: 10377439
We hypothesized that the lipid-activated transcription factor, the peroxisome proliferator-activated receptor alpha (PPARalpha), plays a pivotal role in the cellular metabolic response to fasting. Short-term starvation caused hepatic steatosis, myocardial lipid accumulation, and hypoglycemia, with an inadequate ketogenic response in adult mice lacking PPARalpha (PPARalpha-/-), a phenotype that bears remarkable …
Review article: the efficacy of infliximab in Crohn's disease--healing of fistulae.
Publication Year: Unknown Source: Alimentary pharmacology & therapeutics PMID: 10597336
In the management of fistulae, the current therapeutic approach is the use of a combination of antibiotics and/or a combination of immunomodulatory agents. However, clinicians treating patients with fistulae, particularly those with fistulizing Crohn's disease, have little data from controlled clinical trials of these pharmacologic agents or regimens to substantiate …
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