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Ginkgetin improved experimental colitis by inhibiting intestinal epithelial cell apoptosis through EGFR/PI3K/AKT signaling

Publication Year: 2024 Source: FASEB J PMID: 39003633 DOI: 10.1096/fj.202400211RR

Excessive apoptosis of intestinal epithelial cells leads to intestinal barrier dysfunction, which is not only one of the pathological features of inflammatory bowel disease (IBD) but also a therapeutic target. A natural plant extract, Ginkgetin (GK), has been reported to have anti-apoptotic activity, but its role in IBD is unknown. …

Gegen Qinlian decoction inhibited M1 macrophage polarization and ulcerative colitis progression through regulating histone lactylation

Publication Year: 2024 Source: Tissue Cell PMID: 39003913

No Abstract

Crohn's disease-related versus sporadic colorectal cancer: A stage-matched case-control study based on four decades of experience

Publication Year: 2024 Source: J Surg Oncol PMID: 39004924

No Abstract

IBD functions as a double-edged sword for food allergy in BALB/c mice model

Publication Year: 2024 Source: Immunology PMID: 39005140 DOI: 10.1111/imm.13833

Inflammatory bowel disease (IBD) and food allergy (FA) increase in tandem, but the potential impact of IBD on FA remains unclear. We sought to determine the role of IBD on FA. We first assessed the changes of FA-related risk factors in dextran sulphate sodium salt (DSS) induced colitis mice model. …

Mendelian randomization and Bayesian model averaging of autoimmune diseases and Long COVID

Publication Year: 2024 Source: Front Genet PMID: 39005628 DOI: 10.3389/fgene.2024.1383162

BACKGROUND: Following COVID-19, reports suggest Long COVID and autoimmune diseases (AIDs) in infected individuals. However, bidirectional causal effects between Long COVID and AIDs, which may help to prevent diseases, have not been fully investigated. METHODS: Summary-level data from genome-wide association studies (GWAS) of Long COVID (N = 52615) and AIDs …

Exploration of Berberine Against Ulcerative Colitis via TLR4/NF-κB/HIF-1α Pathway by Bioinformatics and Experimental Validation

Publication Year: 2024 Source: Drug Des Devel Ther PMID: 39006190

No Abstract

Chronic illness trajectory-based nursing intervention improves the self-care abilities of patients with inflammatory bowel disease

Publication Year: 2024 Source: Am J Transl Res PMID: 39006252 DOI: 10.62347/QEOO2698

OBJECTIVE: To explore the effects of chronic illness trajectory model (CITM)-based nursing interventions on anxiety, depression, quality of life, medication adherence, and dietary compliance among patients with inflammatory bowel disease (IBD). METHODS: A retrospective analysis was performed on 112 IBD patients admitted to Shandong Provincial Hospital Affiliated to Shandong First …

HucMSC-Ex alleviates DSS-induced colitis in mice by decreasing mast cell activation via the IL-33/ST2 axis

Publication Year: 2024 Source: Am J Transl Res PMID: 39006299 DOI: 10.62347/EXZE5413

BACKGROUND: Inflammatory bowel disease (IBD) is a chronic inflammatory disease that poses challenges in terms of treatment. The precise mechanism underlying the role of human umbilical cord mesenchymal stem cell-derived exosome (HucMSC-Ex) in the inflammatory repair process of IBD remains elusive. Mucosal mast cells accumulate within the intestinal tract and …

Back to the drawing board: Overview of the next generation of combination therapy for inflammatory bowel disease

Publication Year: 2024 Source: World J Gastroenterol PMID: 39006384 DOI: 10.3748/wjg.v30.i25.3182

Inflammatory bowel disease (IBD) is entering a potentially new era of combined therapeutics. Triantafillidis et al provide an insightful review of the current state of combination therapy, with a focus on the use of a combined biologic and immunomodulator, as well as emerging data on the future potential of dual-biologic …

Computed tomography-based radiomics combined with machine learning allows differentiation between primary intestinal lymphoma and Crohn's disease

Publication Year: 2024 Source: World J Gastroenterol PMID: 39006389

No Abstract

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