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Immunohistochemical Analysis of IL-19 and IL-24 Expression in Inflammatory Bowel Disease (IBD) Patients: Results From a Single Center Retrospective Study
Publication Year: 2024 Source: Cureus PMID: 39007024 DOI: 10.7759/cureus.64441
Background IL-19 and IL-24 induce proinflammatory cytokine production through the Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway. The primary objective of this study was to investigate any changes in IL-19 and IL-24 expression between inflammatory bowel disease (IBD) patients and healthy controls, as well as before and after …
Redo Ileocolic Resection for Crohn's Disease, Does It Palliate the Patients as Good as the Primary Resection?
Publication Year: 2024 Source: J Laparoendosc Adv Surg Tech A PMID: 39007222
No Abstract
Orally Delivered Stimulus-Sensitive Nanomedicine to Harness Teduglutide Efficacy in Inflammatory Bowel Disease
Publication Year: 2024 Source: Small PMID: 39007246 DOI: 10.1002/smll.202402502
Inflammatory Bowel Disease (IBD) is a chronic inflammatory condition affecting the gastrointestinal tract (GIT). Glucagon-like peptide-2 (GLP-2) analogs possess high potential in the treatment of IBD by enhancing intestinal repair and attenuating inflammation. Due to the enzymatic degradation and poor intestinal absorption, GLP-2 analogs are administered parenterally, which leads to …
Elevated WTAP promotes hyperinflammation by increasing m6A modification in inflammatory disease models
Publication Year: 2024 Source: J Clin Invest PMID: 39007267 DOI: 10.1172/JCI177932
Emerging evidence has linked the dysregulation of N6-methyladenosine (m6A) modification to inflammation and inflammatory diseases, but the underlying mechanism still needs investigation. Here, we found that high levels of m6A modification in a variety of hyperinflammatory states are p65-dependent because Wilms tumor 1-associated protein (WTAP), a key component of the …
Update: Induction of Inflammatory Bowel Disease in Immunodeficient Mice by Injection of Naïve CD4(+) T cells (T Cell Transfer Model of Colitis)
Publication Year: 2024 Source: Curr Protoc PMID: 39007482 DOI: 10.1002/cpz1.1092
The intestinal inflammation induced by injection of naive CD4(+) T cells into lymphocyte-deficient hosts (more commonly known as the T cell transfer model of colitis) shares many features of idiopathic inflammatory bowel disease (IBD) in humans, such as epithelial cell hyperplasia, crypt abscess formation, and dense lamina propria lymphocyte infiltration. …
Mucosal Healing Among Black and White Patients With Inflammatory Bowel Disease
Publication Year: 2024 Source: Clin Transl Gastroenterol PMID: 39007493 DOI: 10.14309/ctg.0000000000000737
INTRODUCTION: Crohn's disease and ulcerative colitis are characterized by chronic inflammation of the gastrointestinal tract. Mucosal healing (MH) is a therapeutic goal in patients with inflammatory bowel disease (IBD). Current data suggest that Black patients may experience worse clinical outcomes than White patients with IBD. This study assessed MH between …
Histologic Activity From Neoterminal Ileal Biopsies in Patients With Crohn's Disease in Endoscopic Remission is Associated With Postoperative Recurrence
Publication Year: 2024 Source: Am J Gastroenterol PMID: 39007494
No Abstract
DeepIDA-GRU: a deep learning pipeline for integrative discriminant analysis of cross-sectional and longitudinal multiview data with applications to inflammatory bowel disease classification
Publication Year: 2024 Source: Brief Bioinform PMID: 39007595 DOI: 10.1093/bib/bbae339
No Abstract
Pouchitis: Is It Time to Think Beyond the Inflammation in the Pouch?
Publication Year: 2024 Source: Gastroenterology PMID: 39007794
No Abstract
Gastrointestinal system involvement in patients with primary immunodeficiency: a single center experience
Publication Year: 2024 Source: Scand J Gastroenterol PMID: 39007903 DOI: 10.1080/00365521.2024.2374395
AIM: Primary immunodeficiencies (PIDs) are a heterogeneous disorder group characterized by an impaired immune system, leading to an increased susceptibility to infections and a wide range of clinical manifestations, including gastrointestinal (GI) complications. This study aimed to assess the GI manifestations of PID patients and highlight the significance of atypical …
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