Research Articles Library
Literature Analysis Tools
Advanced Search
Filter by PMID, year, source, DOI and other criteria
Literature Analysis
Analyze research trends and hotspots
Batch Export
Export search results to Excel/PDF
Human Multilineage 3D Spheroids as a Model of Liver Steatosis and Fibrosis.
Publication Year: Unknown Source: International journal of molecular sciences PMID: 30986904
Non-alcoholic fatty liver disease (NAFLD) is the most common liver disorder in western countries. Despite the high prevalence of NAFLD, the underlying biology of the disease progression is not clear, and there are no approved drugs to treat non-alcoholic steatohepatitis (NASH), the most advanced form of the disease. Thus, there …
Type of endothelial cells affects HepaRG cell acetaminophen metabolism in both 2D and 3D porous scaffold cultures.
Publication Year: Unknown Source: Journal of applied toxicology : JAT PMID: 30307041
Recent advances in developing in vitro tissue models show that function of hepatocytes is altered in when cultured in 3D configuration and co-culturing with various non-parenchymal cells. However, tissue source for such non-parenchymal cells on viability and metabolic products of hepatocytes have not been explored. In this study, we evaluated …
Intestinal in vitro cell culture models and their potential to study the effect of food components on intestinal inflammation.
Publication Year: Unknown Source: Critical reviews in food science and nutrition PMID: 30277794
Cell cultures are widely used in pharmaceutical, medical, food/nutrition and biological sciences. In food and nutrition science, intestinal cell culture models of human origin are attracting increasing interest but are still rarely used in investigations of the effects of bioactive food compounds on intestinal inflammation. However, such in vitro models …
Human hepatic 3D spheroids as a model for steatosis and insulin resistance.
Publication Year: Unknown Source: Scientific reports PMID: 30250238
Non-alcoholic fatty liver disease (NAFLD) has emerged as a public health concern as reflected in its widespread distribution in the general population. Yet, treatment options are scarce which is at least in part due to lack of reliable human in vitro disease models. Here, we report a human hepatic 3D …
A nonalcoholic fatty liver disease model in human induced pluripotent stem cell-derived hepatocytes, created by endoplasmic reticulum stress-induced steatosis.
Publication Year: Unknown Source: Disease models & mechanisms PMID: 30254132
Hepatic steatosis, a reversible state of metabolic dysregulation, can promote the onset of nonalcoholic steatohepatitis (NASH), and its transition is thought to be critical in disease evolution. The association between endoplasmic reticulum (ER) stress response and hepatocyte metabolism disorders prompted us to characterize ER stress-induced hepatic metabolic dysfunction in human …
Gut-liver on a chip toward an in vitro model of hepatic steatosis.
Publication Year: Unknown Source: Biotechnology and bioengineering PMID: 29981260
Hepatic steatosis is a process of abnormal lipid deposition within the liver cells, often caused by excessive alcohol uptake or obesity. A conventional in vitro model for hepatic steatosis uses a liver cell culture, treated with fatty acids and measures accumulation of lipids within the cells. This model does not …
Studying non-alcoholic fatty liver disease: the ins and outs of in vivo, ex vivo and in vitro human models.
Publication Year: Unknown Source: Hormone molecular biology and clinical investigation PMID: 30098284
The prevalence of non-alcoholic fatty liver disease (NAFLD) is increasing. Determining the pathogenesis and pathophysiology of human NAFLD will allow for evidence-based prevention strategies, and more targeted mechanistic investigations. Various in vivo, ex situ and in vitro models may be utilised to study NAFLD; but all come with their own …
Characterization of spontaneously-developed non-alcoholic fatty liver disease in aged rhesus monkeys.
Publication Year: Unknown Source: Diabetology & metabolic syndrome PMID: 30214501
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is a global epidemic afflicting 20-30% in the general population. The animal model of NAFLD available at the present are less clinically relevant. In this study. We aimed to establish a NAFLD model of rhesus monkeys and develop an ultrasonographic steatosis score (USS) system …
Food, immunity, and the microbiome.
Publication Year: Unknown Source: Gastroenterology PMID: 25575570
There is increasing evidence that ingested diet-borne components are involved in the pathogenesis of disorders such as inflammatory bowel diseases, atherosclerosis, and type 2 diabetes. Nutrients can have short- and long-term effects in shaping the composition of the microbiota. Western diets (enriched in fat, phosphatidylcholine, and L-carnitine) promote inflammation and …
Disease-specific alterations in the enteric virome in inflammatory bowel disease.
Publication Year: Unknown Source: Cell PMID: 25619688
Decreases in the diversity of enteric bacterial populations are observed in patients with Crohn's disease (CD) and ulcerative colitis (UC). Less is known about the virome in these diseases. We show that the enteric virome is abnormal in CD and UC patients. In-depth analysis of preparations enriched for free virions …
Need more literature?
The current database contains 98453 research articles. If you need to search for more literature or perform AI analysis, please use our knowledge acquisition module or explore external literature resources.
External Resources: Access comprehensive literature databases worldwide