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Concurrent occurrence of ulcerative duodenitis and ulcerative colitis displaying unique responses to golimumab and ustekinumab
Publication Year: 2024 Source: Clin J Gastroenterol PMID: 39023824
No Abstract
CRIg+ macrophages deficiency enhanced inflammation damage in IBD due to gut extracellular vesicles containing microbial DNA
Publication Year: 2024 Source: Gut Microbes PMID: 39024479 DOI: 10.1080/19490976.2024.2379633
Gut microbiota-derived extracellular vesicles (mEVs) are reported to regulate inflammatory response by delivering bacterial products into host cells. The complement receptor of the immunoglobulin superfamily macrophages (CRIg+ Mphi) could clear invading bacteria and their derivatives. Here, we investigate the role of CRIg+ Mphi and the mechanism by which mEVs regulate …
TWIST1+FAP+ fibroblasts in the pathogenesis of intestinal fibrosis in Crohn's disease
Publication Year: 2024 Source: J Clin Invest PMID: 39024569
No Abstract
Paeoniae Decoction restores intestinal barrier dysfunction by promoting the interaction between ILC3 and gut flora
Publication Year: 2024 Source: Phytomedicine PMID: 39024673
No Abstract
Adipose-derived mesenchymal stromal cells alleviate intestinal fibrosis: The role of tumor necrosis factor-stimulated gene 6 protein
Publication Year: 2024 Source: Int Immunopharmacol PMID: 39024752
No Abstract
Targeting the mesentery with surgery in ileocolic Crohn's disease: where do we stand?
Publication Year: 2024 Source: Lancet Gastroenterol Hepatol PMID: 39025099 DOI: 10.1016/S2468-1253(24)00186-9
No Abstract
Effect of mesenteric sparing or extended resection in primary ileocolic resection for Crohn's disease on postoperative endoscopic recurrence (SPICY): an international, randomised controlled trial
Publication Year: 2024 Source: Lancet Gastroenterol Hepatol PMID: 39025100
No Abstract
Clinicopathologic and Molecular Characterization of Inflammatory Bowel Disease-Associated Neuroendocrine Carcinomas and Mixed Neuroendocrine-Non-Neuroendocrine Neoplasms
Publication Year: 2024 Source: Mod Pathol PMID: 39025404 DOI: 10.1016/j.modpat.2024.100566
The pathogenesis of neuroendocrine carcinomas (NECs) and mixed neuroendocrine-non-neuroendocrine neoplasms (MiNENs) in the gastrointestinal tract remains poorly understood. This study aims to characterize the clinicopathologic and molecular features of NEC/MiNEN in patients with inflammatory bowel disease (IBD). Eighteen surgically resected IBD-associated intestinal carcinomas with a minimum of 30% neuroendocrine component …
Paediatric Crohn's disease: histologic findings at initial presentation
Publication Year: 2024 Source: J Clin Pathol PMID: 39025491
No Abstract
Cellular immunotherapies and immune cell depleting therapies in inflammatory bowel diseases: the next magic bullet?
Publication Year: 2024 Source: Gut PMID: 39025492 DOI: 10.1136/gutjnl-2024-332919
Despite significant advances in biologic and small molecule treatments and the emergence of combination therapies to treat inflammatory bowel diseases (IBD) a large unmet need remains to control intestinal inflammation. New approaches targeting several pathways simultaneously with a favorable safety profile and agents that trigger anti-inflammatory pathways to drive durable …
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