| Target ID: | Tar17 |
|---|---|
| ID: | T48470 |
| Target Name: | Hormone unspecific (HOM) |
| Target Type: | Protein |
| CID: | -- |
| URL: | https://db.idrblab.net/ttd/data/target/details/T48470 |
| Related Drugs: | -- |
Knowledge Graph
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| No data available | |||||||
Negative regulation of Toll-like receptor signaling plays an essential role in …
PMID: 21182089
Year: 2011
Relationship Type:
Mechanism Investigation
Score: 5.3
A healthy intestinal tract is characterized by controlled homeostasis due to the balanced interaction between commensal bacteria and the host mucosal…
Endoplasmic reticulum stress-activated C/EBP homologous protein enhances nuclea…
PMID: 20829347
Year: 2010
Relationship Type:
Clinical Research
Score: 5.3
Endoplasmic reticulum (ER) stress is a causative factor of inflammatory bowel diseases. ER stress mediators, including CCAAT enhancer-binding protein…
Diverse targets of the transcription factor STAT3 contribute to T cell pathogen…
PMID: 20493732
Year: 2010
Relationship Type:
Correlation Studies
Score: 5.3
STAT3, an essential transcription factor with pleiotropic functions, plays critical roles in the pathogenesis of autoimmunity. Despite recent data li…
The role of TLRs, NLRs, and RLRs in mucosal innate immunity and homeostasis
PMID: 19890268
Year: 2010
Relationship Type:
Mechanism Investigation
Score: 5.3
The mucosal surfaces of the gastrointestinal tract are continually exposed to an enormous antigenic load of microbial and dietary origin, yet homeost…
Interleukin-23/Th17 pathways and inflammatory bowel disease
PMID: 19253307
Year: 2009
Relationship Type:
Mechanism Investigation
Score: 5.3
Inflammatory bowel disease (IBD) is characterized by unrestrained T-cell activation that results in the production of a variety of inflammatory cyto…
Role of discs large homolog 5
PMID: 16773680
Year: 2006
Relationship Type:
Mechanism Investigation
Score: 5.3
Active inflammatory bowel disease (IBD) is often associated with simultaneous inflammation in the skin, eyes and joints. Inflammatory disease in the…
Flavokawain B inhibits NF-κB inflammatory signaling pathway activation in infla…
PMID: 38583725
Year: 2024
Relationship Type:
Mechanism Investigation
Score: 5.2
Inflammatory bowel disease (IBD) is characterized by recurrent inflammatory reactions in the intestinal mucosa, including ulcerative colitis (UC) and…
Direct inhibition of the TXNIP-NLRP3-GSDMD pathway reduces pyroptosis in colono…
PMID: 40195510
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.0
Ulcerative colitis (UC) is a chronic inflammatory bowel disease. The etiology of UC is multifaceted, and the underlying pathogenesis remains incomple…
Targeting macrophage glucose metabolism: Polysaccharide-iron nanozyme-mediated …
PMID: 40633358
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.0
Inflammatory bowel disease (IBD) is a chronic immune-mediated disorder characterized by intestinal inflammation, with frequent progression to complic…
Anchang Yuyang Decoction inhibits experimental colitis-related carcinogenesis b…
PMID: 38428656
Year: 2024
Relationship Type:
Mechanism Investigation
Score: 5.0
ETHNOPHARMACOLOGICAL RELEVANCE: Inflammatory bowel disease (IBD) presents a risk of carcinogenesis, which escalates with the duration of IBD. Persist…
Red Cabbage Juice-Mediated Gut Microbiota Modulation Improves Intestinal Epithe…
PMID: 38203712
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.0
Gut microbiota plays a crucial role in inflammatory bowel diseases (IBD) and can potentially prevent IBD through microbial-derived metabolites, makin…
Red cabbage juice-mediated gut microbiota modulation improves intestinal epithe…
PMID: 37662255
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.0
Gut microbiota plays a crucial role in inflammatory bowel disease (IBD) and has therapeutic benefits. Thus, targeting the gut microbiota is a promisi…
WASP-mediated regulation of anti-inflammatory macrophages is IL-10 dependent an…
PMID: 29725003
Year: 2018
Relationship Type:
Mechanism Investigation
Score: 5.0
BACKGROUND AND AIMS: Oral drug delivery is the most attractive pathway for ulcerative colitis [UC] therapy, since it has many advantages. However, t…
Inflammation-induced, 3'UTR-dependent translational inhibition of Hsp70 mRNA im…
PMID: 19299581
Year: 2009
Relationship Type:
Mechanism Investigation
Score: 5.0
Comment in Gut. 2006 Sep;55(9):1226-7. BACKGROUND AND AIMS: SAMP1/Yit mice spontaneously develops intestinal inflammation. Previously, we demon…
Characterization of feline T cell receptor gamma (TCRG) variable region genes f…
PMID: 15963816
Year: 2005
Relationship Type:
Mechanism Investigation
Score: 5.0
Using monolayers of intestinal (Caco-2) cells as a model for studying inflammatory bowel disease (IBD), we previously showed that nuclear factor-ka…
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| bio44521 | CHEMBL4297525 | Small molecule | RELAMORELIN | 790.99 | C43H50N8O5S | BASE | Details |
| bio44522 | CHEMBL1201620 | Protein | SOMATREM | -- | -- | -- | Details |
| bio44523 | CHEMBL4650335 | Protein | NENDRATAREOTIDE UZATANSINE | 1786.58 | C83H109ClN14O20S4 | -- | Details |
| bio44524 | CHEMBL58547 | Protein | IPAMORELIN | 711.87 | C38H49N9O5 | BASE | Details |
| bio44525 | CHEMBL2357192 | Protein | DESLORELIN ACETATE | 1342.53 | C66H87N17O14 | -- | Details |
| bio44526 | CHEMBL1200516 | Protein | GONADORELIN HYDROCHLORIDE | 1218.77 | C55H76ClN17O13 | -- | Details |
| bio44527 | CHEMBL4540843 | Protein | PANCREATIC POLYPEPTIDE | 4181.78 | C185H287N53O54S2 | -- | Details |
| bio44528 | CHEMBL113313 | Small molecule | CAPROMORELIN | 505.62 | C28H35N5O4 | NEUTRAL | Details |
| bio44529 | CHEMBL1680 | Protein | OCTREOTIDE | 1019.26 | C49H66N10O10S2 | -- | Details |
| bio44530 | CHEMBL1201515 | Protein | PEGVISOMANT | -- | -- | -- | Details |
| Strategy ID | Therapy Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| No data available | |||||